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Female Patient
Lab Interpretation, LLC18124 Wedge Pkwy, Ste 432Reno, NV 89511 (775) 851-3337(775) 851-3363 Faxwww.labinterpretation.com LabAssist™ Organic Acids & Environmental Pollutants Report
Patient
Printed on Friday, August 14, 2009 for: US BioTek Laboratories
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PATENTED, U.S. PATENTS 5,746,204 and 6,063,026. OTHER U.S. AND FOREIGN PATENTS PENDING. ALL RIGHTS RESERVED.
Copyright (c) 1994-2008 Crayhon Research, Inc.
Basic Status High/Low - Environmental Pollutants Exposure on 4/29/2009
Female Patient
Organic Acids & Environmental Pollutants Date: 4/29/2009
The % Status is the weighted deviation of the laboratory result.
Low Results
High Results
Copyright (c) 1994-2008 Crayhon Research, Inc.
Basic Status High/Low - Urine Organic Acid on 4/29/2009
Female Patient
Organic Acids & Environmental Pollutants Date: 4/29/2009
The % Status is the weighted deviation of the laboratory result.
Low Results
High Results
Copyright (c) 1994-2008 Crayhon Research, Inc.
Basic Status Alphabetic - Environmental Pollutants Exposure on 4/29/2009
Female Patient
Organic Acids & Environmental Pollutants Date: 4/29/2009
The % Status is the weighted deviation of the laboratory result relative to the range.
2-Methylhippurate
3,4-Dimethylhippurate
Hippurate
Phenylglyoxylate
Phthalate
p-Hydroxybenzoate
Quinolinate
Total Status Deviation
Total Status Skew
Copyright (c) 1994-2008 Crayhon Research, Inc.
Basic Status Alphabetic - Urine Organic Acid on 4/29/2009
Female Patient
Organic Acids & Environmental Pollutants Date: 4/29/2009
The % Status is the weighted deviation of the laboratory result relative to the range.
3-Indoleacetate
5-Hydroxyindoleacetate
a-Ketoglutarate
Benzoate
b-Hydroxybutyrate
CA Cycle Return
cis-Aconitate
Ethylmalonate
Hippurate
Hydroxymethylglutarate
Isocitrate
Kynurenate
Methylsuccinate
p-Hydroxybenzoate
p-Hydroxyphenyllactate
Quinolinate
Tricarballylate
Vanilmandelate
Total Status Deviation
Total Status Skew
Copyright (c) 1994-2008 Crayhon Research, Inc.
Client Summary Review
Female Patient
Organic Acids & Environmental Pollutants Date: 4/29/2009
Nutritional Support
The following supplements may help to balance your biochemistry. Consult your practitioner.
1-Carnitine + Biotin
3x daily 100 mg
See Nutrition Detail
1-CoEnzyme Q10
1-Oral Electrolytes
2 x daily 50 mg (2x daily 100mg if HMG over 250% elevated)
1-Phthalate Reduction Protocol
1-Probiotics
See Nutrition Detail
1-Styrene Detoxification Protocol
1-Xylene Detoxification Protocol
See Nutrition Detail
See Nutrition Detail
Copyright (c) 1994-2008 Crayhon Research, Inc.
Practitioner Summary Review
Female Patient
Organic Acids & Environmental Pollutants Date: 4/29/2009
Out-Of-Balance Panel Values
The following panels have a PSD of greater than 25% indicating need for further review. PSD is the Panel Status Deviation,
or the average imbalance of that subset of results. The PSS is the Panel Status Skew, or the direction, negative (deficiency)
or positive (excess), of that subset of results.
Panel Name
Lab Reported out-of-range Values
The following results are out-of-range (as reported by the lab), and should be carefully reviewed.
a-Ketoglutarate ( 540.83%)
High levels of this organic acid may be indicative of poor amino acid metabolism or a need for both B-complex and lipoicacid.
Hydroxymethylglutarate ( 470.00%)
This organic acid, when high, may be indicative of a low level of Coenzyme Q10, statin drug use or mitochondrialdysfunction.
p-Hydroxyphenyllactate ( 170.00%)
High levels of this organic acid are indicative of an ongoing pro-oxidative response. Increased tissue growth, oxidativechallenges due to toxicity, inborn errors of metabolism and low levels of vitamin C may be reasons for high results.
Kynurenate ( 157.14%)
A high reading of this by-product of the breakdown of the amino acid tryptophan is consistent with a vitamin B6deficiency, possible inflammatory processes, interferon-gamma stimulated macrophages or excessive tryptophansupplementation (not 5-HTP). Abnormally high levels can cause and increase in pain sensations and may, in multiplesclerosis patients, be a marker for an exacerbation period.
Tricarballylate ( 150.00%)
Elevated levels may be due to an overgrowth of intestinal bacteria. This organic acid binds very tightly to magnesium,possibly zinc and calcium and may induce a deficiency in these important minerals. The bacterium that produces thiselement is also very fast growing and may cause numerous vitamin and mineral deficiencies. As it may interfere withcarbohydrate absorption, a diet low in carbohydrates is suggested.
Malate ( 84.99%)
A high level of this organic acid may be indicative of a need for certain nutrients such as niacin and Coenzyme Q10. Ifcitrate, fumarate, and a-ketoglutarate are high as well, it may be due to a cytochrome C oxidase deficiency. Elevations ofmalate are also seen in individuals with Syndrome X. Tartaric acid has also been implicated, although theoretically, toblock malate within the citric acid cycle.
Drugs which may have an adverse affect:
Lithium Carbonate
Hippurate ( -68.39%)
Low hippurate is not typically indicative of any problems except when benzoate is elevated which would suggest poorconjugation with glycine and possibly impaired Phase II detoxification capacity.
Hippurate ( -68.39%)
Low hippurate is not typically indicative of any problems except when benzoate is elevated which would suggest poorconjugation with glycine and possibly impaired Phase II detoxification capacity.
Copyright (c) 1994-2008 Crayhon Research, Inc.
Practitioner Summary Review (continued)
Female Patient
Organic Acids & Environmental Pollutants Date: 4/29/2009
Vanilmandelate ( 63.33%)
This result is seen with chronic stress, increased catecholamine synthesis, elevated caffeine ingestion, as well as the useof ephedra, and pseudoephedrine found in decongestants. High levels of this organic acid should be correlated withhomovanillic acid (HVA) for potential abnormal cell growth.
Drugs which may have an adverse affect:
Insulin, Reserpine
CA Cycle Phase 6 ( -60.02%)
The last phase of the citric acid cycle, this stage marks the conversion of Fumarate into Malate. When the ratio is low,this may signify that the body is not refilling its losses along the entire cycle. Supplementing with a broad spectrumamino acid along with niacin may help restore balance.
5-Hydroxyindoleacetate ( 53.39%)
An elevation of this metabolite of the breakdown of serotonin may be due to the use of serotonin-specific re-uptakeinhibitor (SSRI) drugs or the release of serotonin from the central nervous system, intestinal argentaffin cells or platelets.
Drugs which may have an adverse affect:
Acetaminophen, Prozac, Reserpine
CA Cycle Phase 1 ( 51.23%)
This is the first phase of the citric acid cycle moving from Citrate to cis-Aconitate. A high reading may indicate adisruption in the efficiency of energy production. It can also be due to a problem clearing ammonia due to an arginaseenzyme deficiency.
3,4-Dimethylhippurate ( -50.00%)
A low reading such as this is desirable for this marker although it may indicate an inability to excrete the solventtrimethylbenzene.
Copyright (c) 1994-2008 Crayhon Research, Inc.
Nutrition - Detail
Female Patient
Organic Acids & Environmental Pollutants Date: 4/29/2009
Nutritional and herbal information contained in this report is based upon research related to imbalances in yourchemistry. The recommendations are based upon the information provided, without interpretation. This must bedone with the help of a qualified health care professional.
1-5-HTP 3x daily 100 mg
Rationale
Decreased
Increased
5-Hydroxytryptophan is indicated due to the high level of 5-HIAA in urine which suggests serotonin catabolism and a possible loss of tryptophanreserves.
1-Carnitine + Biotin See Nutrition Detail
L-CARNITINE + BIOTIN
Decreased
Increased
Carnitine is sometimes considered a non-essential amino acid which is synthesized in the liver and kidneys from lysine. methionine and other nutrients. It is critical in the metabolism of fat and transport of long-chainessential fatty acids as well as being cardiac protective. Biotin is animportant addition anytime you take carnitine to avoid stimulatinggluconeogenesis. You need to take 1 mg of biotin for every 500 mg ofcarnitine.
Adults should take 1-2 grams of carnitine with 2-4 milligrams of biotindailyChildren should take 500 mg to 1 gram of carnitine with 1-2 milligrams ofbiotin daily 1-CoEnzyme Q10 2 x daily 50 mg 2x daily 100mg if HMG over 250% elevated
COENZYME Q10
Decreased
Increased
CoEnzyme Q10 is an essential component of the mitochondria of the energy producing unit of the cell. Its beneficial effects include increasedenergy, as well as prevention of cardiovascular disease and cancer.
Clinical responses may take up to 8 weeks according to some researchso patience is necessary during supplementation.
1-Oral Electrolytes 2x daily
ORAL ELECTROLYTES
Decreased
Increased
The main electrolytes in the human body are sodium, potassium, phosphorus, calcium, chloride, magnesium and bicarbonate. Duringillness, the equilibrium present in healthy individuals, is disturbed. Awell balanced formula is helpful in restoring a state of equilibrium. Inmany cases of intestinal dysbiosis, alkalizing the system withelectrolytes may aid in dislodging the microbiota from the gut wall.
Copyright (c) 1994-2008 Crayhon Research, Inc.
Nutrition - Detail
Female Patient
Organic Acids & Environmental Pollutants Date: 4/29/2009
Nutritional and herbal information contained in this report is based upon research related to imbalances in yourchemistry. The recommendations are based upon the information provided, without interpretation. This must bedone with the help of a qualified health care professional.
1-Phthalate Reduction Protocol See Nutrition Detail
Rationale
Decreased
Increased
Phthalates are ubiquitous chemicals found wherever plastics are found.
They are powerful endocrine disruptors as well as potentially damagingto developing fetuses. Avoidance of plastics while very difficult is animportant first step in lowering body burden. Never microwave or heatfood in a plastic container. Improving both phase I and phase IIdetoxification is also critical.
Recommendations:AdultsAmino Acids - 5-10 grams of a broad spectrum supplement with glycineBroad Spectrum Antioxidants - 2x dailyIncreased Fluid Intake preferably with an electrolyte addedAvoid SalicylatesVItamin E - 400 IU 2x daily (mixed tocopherols)Magnesium - 200 mg dailyZinc - 25 mg dailyChildrenAmino Acids - 2 grams of a broad spectrum supplement with glycineBroad Spectrum Antioxidants - 1x dailyIncreased Fluid Intake preferably with an electrolyte addedAvoid SalicylatesVItamin E - 400 IU 1x daily (mixed tocopherols)Magnesium - 125 mg dailyZinc - 15 mg daily 1-Probiotics 3x daily
PROBIOTICS
Decreased
Increased
A comprehensive probiotic protocol has shown promise in relieving intestinal bacteria and parasitic infections. It is important to use a broadspectrum of probiotic organisms with a high concentration, preferably20-25 billion of live organisms per capsule. 1-Styrene Detoxification Protocol See Nutrition Detail
STYRENE DETOXIFICATION PROTOCOL
Decreased
Increased
Styrene detoxification requires an increased level of glutathione. In order to effectively increase glutathione levels it is necessary to supply both the necessary amino acids (cysteine, glutamic acid and glycine) aswell as the nutrients (pyridoxine, riboflavin and folic acid) to make theconversion.
AdultBroad Spectrum Amino Acid - 5-10 grams dailyGlycine - 500 mg twice dailyN-acetyl-cysteine - 500 mg twice dailyB-complex - twice dailyVitamin E - 400 IU once daily (mixed tocopherols)Vitamin C - 500 mg twice dailySelenium - 200 mcg once dailyChildrenBroad Spectrum Amino Acid - 2 grams dailyGlycine - 250 mg twice dailyN-acetyl-cysteine - 250 mg once dailyB-complex - 1 time dailyVitamin E - 200 IU once daily (mixed tocopherols)Vitamin C - 500 mg 1 time daily Copyright (c) 1994-2008 Crayhon Research, Inc.
Nutrition - Detail
Female Patient
Organic Acids & Environmental Pollutants Date: 4/29/2009
Nutritional and herbal information contained in this report is based upon research related to imbalances in yourchemistry. The recommendations are based upon the information provided, without interpretation. This must bedone with the help of a qualified health care professional.
1-Xylene Detoxification Protocol See Nutrition Detail
Rationale
Decreased
Increased
Xylene, a ubiquitous petrochemical solvent, is first oxidized via p450 enzymes then conjugated with glycine to for 2- and 3-methylhippurate.
The following nutritional support is recommended to help with theexcretion of this toxin.
AdultsGlycine - 500 mg 2 - 3 times dailyIncreased fluid intake, preferably with added electrolytesBroad Spectrum Antioxidants - 2 times dailymake sure the antioxidants include Vitamins C, E and SeleniumChildrenGlycine 250 mg 2 times dailyBroad Spectrum Antioxidants - 1 time daily Copyright (c) 1994-2008 Crayhon Research, Inc.
Drug Interactions
Female Patient
Organic Acids & Environmental Pollutants Date: 4/29/2009
Drugs listed below tend to further aggravate elements of blood chemistry that are out of range (H or L). The(#) after each drug denotes the number of times that drug is flagged as being potentially harmful.
Copyright (c) 1994-2008 Crayhon Research, Inc.
Panel/Subset Report
Female Patient
Organic Acids & Environmental Pollutants Date: 4/29/2009
Automotive Sources
PSD: 24.95
2-Methylhippurate[H], 3-Methylhippurate, Mandelate, PSS: 18.41
Phenylglyoxylate[H], M + P[H], t,t-Muconic Acid.
Car exhaust is a leading source of environmental solventexposure. Running on busy streets next to traffic, commuting inheavy traffic, and living in large urban areas are sources ofexposure.
Cosmetic Sources
PSD: 22.38
Phthalate[H], Monoethyl Phthalate, p-Hydroxybenzoate[H], PSS: 18.88
A number of cosmetics are made using parabens, phthalates andbenzene derivatives. Careful avoidance of those cosmetics iswarranted if this panel is elevated. A resource to find out moreabout this topic is the website run by the Environmental WorkingGroup, www.ewg.org and their report Skin Deep.
Paint and Solvents
PSD: 26.45
3-Methylhippurate, Mandelate, Phenylglyoxylate[H], M + P[H].
PSS: 16.63
Paints and solvents are often found with styrene and xylene.
Airing out a newly painted house is advisable. Also, for anyoneusing paints and solvents, make sure the place they are usingthem is well-ventilated.
Phthalates
PSD: 29.07
Phthalate[H], Monoethyl Phthalate, Quinolinate[H].
PSS: 24.41
High levels of phthalates have been connected to a number ofhealth issues. Avoidance is critical and detoxification may benecessary.
Plastic Sources
PSD: 26.23
Phthalate[H], Monoethyl Phthalate, Mandelate, Phenylglyoxylate[H], PSS: 23.43
Plastics are often made with styrene and phthalates. If this panelis elevated, it is suggested that the patient should avoid heatingplastics in the microwave, leaving plastic water bottles in the car,and drinking hot liquids out of styrofoam cups.
Copyright (c) 1994-2008 Crayhon Research, Inc.
Panel/Subset Report
Female Patient
Organic Acids & Environmental Pollutants Date: 4/29/2009
Water Sources
PSD: 30.02
t,t-Muconic Acid, Mandelate, Phenylglyoxylate[H], M + P[H], PSS: 13.35
2-Methylhippurate[H], 3,4-Dimethylhippurate[L].
According to research, many water supplies worldwide aretainted with a number of petrochemicals including, but not limitedto trimethylbenzene, toluene, styrene, and benzene. A highreading of this panel may warrent testing of the patient's watersupply.
B-Complex Markers
PSD: 16.84
b-Hydroxyisovalerate, a-Ketoisovalerate, a-Ketoisocaproate, PSS: -10.84
a-Keto-b-methylvalerate, Methylmalonate.
A normal panel profile such as this is an indicator of adequateintake of B-complex vitamins.
BCAA Catabolism
PSD: 16.22
a-Ketoisovalerate, a-Ketoisocaproate, a-Keto-b-methylvalerate.
PSS: -16.22
A normal reading in this panel suggest proper amino acid stores.
CAC Cycle Ratios
PSD: 40.86
CA Cycle Phase 1[H], CA Cycle Phase 2, CA Cycle Phase 3[L], CA PSS: -24.86
Cycle Phase 4[L], CA Cycle Phase 5[L], CA Cycle Phase 6[L], CA This panel reflects steps of the citric acid cycle. A low readingmay be indicative of poor energy production and/or vitamin,mineral and amino acid deficiencies.
Carbohydrate Metabolism
PSD: 23.22
Lactate[L], Pyruvate, a-Hydroxybutyrate, b-Hydroxybutyrate[L].
PSS: -22.07
A normal reading is consistant with the proper metabolism ofdietary carbohydrates.
Copyright (c) 1994-2008 Crayhon Research, Inc.
Panel/Subset Report
Female Patient
Organic Acids & Environmental Pollutants Date: 4/29/2009
Energy Production
PSD: 151.98
Citrate, cis-Aconitate[H], Isocitrate[H], a-Ketoglutarate[H], Succinate, PSS: 151.98
Fumarate, Malate[H], Hydroxymethylglutarate[H].
This panel profile result may be due to a breakdown in the CitricAcid Cycle. Supplementation with specific amino acidcombinations and precursor vitamins and minerals may help toreverse this imbalance. Review the Nutritional Support sectionfor further details.
Fatty Acid Metabolism
PSD: 28.01
Adipate[H], Suberate, Ethylmalonate[H].
PSS: 20.32
These urinary markers give us a picture into the metabolism offatty acids. Elevated results are indicative of an abnormalmetabolism of fatty acids and may indicate the need foradditional carnitine and riboflavin. Careful review of fatty acidsupplementation may be helpful as well.
Intestinal Dysbiosis
PSD: 119.00
p-Hydroxyphenyllactate[H], Tricarballylate[H], p-Hydroxybenzoate[H].
PSS: 119.00
This panel profile may be indicative of intestinal dysbiosis. Poorabsorption and metabolism of proteins, fats and carbohydratesmay occur. A review of potential bacteria, protozoa, Clostridialspp., yeast or fungus may be necessary.
Liver Detox Indicators
PSD: 15.48
Orotate, Pyroglutamate, a-Hydroxybutyrate.
PSS: -15.48
A normal liver detox panel is consistant with good liverdetoxification processes.
Neurotransmitters
PSD: 67.79
Vanilmandelate[H], Homovanillate, 5-Hydroxyindoleacetate[H], PSS: 67.79
The panel profile seen here may be due to the use of serotoninre-uptake inhibitors such as Prozac or poor catecholaminecatabolism.
Copyright (c) 1994-2008 Crayhon Research, Inc.
Clinical Correlation
Female Patient
Organic Acids & Environmental Pollutants Date: 4/29/2009
This report "MATCHES" clinical observations with the lab test. Elements shown, normal and abnormal, tend tocharacterize the observation. Highlighted elements are those reported to "MATCH" the characteristics of theclinical observation. Others are NOT matches but are elements in the observation.
Chronic Stress Disorder ()
66.67% (2 of 3)
Decreased
Normal
Increased
63.33 Vanilmandelate
53.39 5-Hydroxyindoleacetate
Mitochondrial Inefficiencies ()
66.67% (2 of 3)
Decreased
Normal
Increased
35.83 Isocitrate
48.55 cis-Aconitate
When this pattern shows up, suspect mitochondrial ineffiencies which may be due to toxicity issues.
Copyright (c) 1994-2008 Crayhon Research, Inc.

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