Medicine.fiu.edu

Hong Ding, PhD

Current Title: Assistant Professor
Current working address:
Department of Immunology, Herbert Wertheim College of Medicine
Florida International University
11200 SW 8th ST., AHC 1-308
Miami, FL33199, USA
Tel: (305)348-1490 (Lab), (716)907-4955 (Cell)/Fax: (305)348-1109
Email: [email protected] or [email protected]

A. EDUCATION
 PhD of Pharmaceutical Sciences, West China School of Pharmacy, Sichuan University, China  Master of Pharmaceutical Chemistry, Sichuan Industrial Institute of Antibiotics, China  Bachelor in Microbiology, Sichuan University of Science and Technology, China
B. RESEARCH EXPERIENCE
2012-Now Assistant Professor, Department of Immunology, College of Medicine, Florida International
University, Miami, FL, USA
2010-2012 Postdoctoral Research Fellow, Department of Pharmaceutical Sciences, The State
University of New York at Buffalo, NY, USA
2006-2010 Postdoctoral Research Associate, Department of Chemistry, The State University of New
York at Buffalo, NY, USA
1999-2003 Research Assistant Professor, Department of Novel Antibiotics, Sichuan Industrial Institute of
Antibiotics (SIIA), China
C. RESEARCH SPECIALTIES
 Tumor and CNS Targeting Drug Delivery Systems  Nanomedicine and Nanotheranostics  Chemical Synthesis and Structural Modification for Drugs and Delivery Vehicles  Immunogenicity and Pharmacokinetics  Industrial Procedure on Chemical Drugs and Formulation  Quality Control by Design Strategy D. PUBLICATIONS, ABSTRACTS, PATENT & BOOK CHAPTER
D.1 Peer-reviewed journal publications
1) H. Ding, F. Wu. Images guided biodistribution and pharmacokinetic studies of theranostics. Theranostics,
2012, Doi:10.7150/thno.4652.
2) A. Peng, G Nakamura, H. Ding, and SV. Balu-Iyer. PEGylation of a Factor VIII-Phosphatidylinositol
Complex: Pharmacokinetics and Immunogenicity in Hemophilia A Mice. AAPS Journal. 2012, 14(1):35-42.
3) F. Wu, SG. Bhansali, M. Tamhane, R. Kumar, LA. Vathy, H. Ding, K Yong, EJ. Bergey, PN. Prasad, ME.
Morris. Non-invasive real time fluorescence imaging of lymphatic uptake of BSA-IRDye 680 conjugate
administered subcutaneously in mice. Journal of Pharmaceutical Sciences, 2012, 101(5):1744-1754.
4) RT. Martuscello, RN. Spengler, AC. Bonoiu, BA. Davidson, J. Helsinki, H. Ding, S. Mahajan, EJ. Bergey,
PR. Knight, PN. Prasad, TA. Ignatowski. Increasing TNF levels in the rat hippocampus produces
neuropathic pain-like symptoms. Pain, 2012, accepted.
5). JL. May, F.Erogbogbo, K. Yong, H. Ding, WC Law, MT. Swihart, PN. Prasad. Enhancing silicon
quantum dot uptake by pancreatic cancer cells via pluronic® encapsulation and antibody targeting. Journal
of Solid Tumors, 2012, Vol. 2, No. 3. Doi: 10.5430/jst.v2n3p24
6). F. Erogbogbo, CW. Chang, JL. May, L. Liu, R. Kumar, WC. Law, H. Ding, KT. Yong, I. Roy, M.
Sheshadri, MT. Swihart, PN. Prasad. Bioconjugation of Luminescent Silicon Quantum Dots to
Gadolinium Ions for Bioimaging Applications. Nanoscale, 2012. 4(17):5483-5489.
7) R. Masood, I. Roy, S. Zu, C. Hochstim, K. Yong, W. Law, H. Ding, UK. Sinha, PN. Prasad. Gold
nanorod–sphingosine kinase siRNA nanocomplexes: a novel therapeutic tool for potent radiosensitization of
head and neck cancer. Integrative Biology, 2012, 4(2):132-141
8) H. Ding, KT. Yong, WC. Law, I. Roy, R. Hu, F. Wu, et al. Non-invasive tumor detection in small animal
using novel functional Pluronics nanomicelles conjugated with anti-mesothelin antibody. Nanoscale, 2011,
3(4):1813-1822.
9) H. Ding, K. Yong, I. Roy, R. Hu, F. Wu, et al. Bioconjugated PLGA-4-arm-PEG branched polymeric
nanoparticles as a novel tumor targeting carrier. Nanotechnology. 2011, 22(16), Article Number: 165101
(12pp).
10) L. Liu, H. Ding, KT. Yong, I. Roy, WC. Law, A. Kopwitthaya, et al. Application of gold nanorods for
plasmonic and magnetic imaging of cancer cells. Plasmonics, 2011, 6(1): 105-112.
11) L. Liu, WC. Law, KT. Yong, I. Roy, H. Ding, F. Erogbogbo, et al. Multimodal imaging probes based on
Gd-DOTA conjugated quantum dot nanomicelles. Analyst. 2011, 136:1881-1886.
12) F. Erogbogbo, CA. Tien, CW. Chang, H. Ding, WC. Law, I. Roy, et al. Bioconjugation of luminescent
silicon quantum dots for selective uptake by cancer cells. Bioconjugate Chemistry. 2011, 22: 1081-1088.
13) AC. Bonoiu, EJ. Bergey, H. Ding, R. Hu, R. Kumar, et al. Gold nanorod-siRNA induces efficient in vivo
gene silencing in the rat hippocampus. Nanomedicine: Nanotechnology, Biology and Medicine. 2011, 6(4):
617-630.
14) S. Mahajan, R. Aalinkeel, J. Reynolds, B. Nair, D.Sykes, WC. Law, H. Ding, EJ. Bergey, PN. Prasad,
SA. Schwartz. Nanotherapeutics using a HIV-1 poly A and trans-activator of the HIV-1 LTR (TAR) specific
siRNA. Pathology Research International. 2011, 2011: 719139.
15) F. Erogbogbo, K. Yong, R. Hu, WC. Law, W. Zhao, H. Ding, F. Wu, R. Kumar, et al. In vivo targeted
cancer imaging, sentinel lymph node mapping and multi-channel imaging with biocompatible silicon
nanocrystals. ACS Nano, 2011, 5(1): 413-423.
16) K. Chakravarthy, A. Bonoiu, W. Davis, P. Ranian, H. Ding, H. Rui, JB. Bowzard, EJ. Bergey, JM. Katz,
PR. Knight, S. Sanbhara, PN. Prasad. Gold nanorods delivery of an ssRNA immune activator inhibits
pandemic H1N1 influenza viral replication. Proceedings of the National Academy of Sciences of the United
States of America (PNAS-USA). 2010, 107(22):10172-10177
17) N. Vij, T. Min, R. Marasigan, C. Belcher, S. Mazur, H. Ding, KT. Yong, I. Roy. Development of
PEGylated PLGA nanoparticle for controlled and sustained drug delivery in cystic fibrosis. Journal of
Nanobiotechnology, 2010, 8: 22.
18) KV. Chakravarthy, BA. Davidson, JD. Helinski, H. Ding, WC. Law, et al. Doxorubin conjugated
quantum dots to target alveolar macrophages/inflammation. Nanomedicine: Nanotechnology, Biology and
Medicine. 2010, 7: 88-96.
19) F. Erogbogbo, R. Hu, WC. Law, H. Ding, CW. Chang, PN. Prasad, MT. Swihart. Biocompatible
magnetofluorescent probes: luminescent silicon quantum dots coupled with superparamagnetic iron(III)
oxide. ACS Nano, 2010, 4(9): 5131-5138
20) A. Kopwitthaya, KT. Yong, R. Hu, I. Roy, H. Ding, LA. Vathy, et al. Biocompatible PEGylated gold
nanorods as colored contrast agents for targeted in vivo cancer applications. Nanotechnoloy, 2010, 21(31),
Article Number: 315101.
21) J. Zhu, KT. Yong, I. Roy, R. Hu, H. Ding, L. Zhao, MT. Swihart, et al. Additive controlled synthesis of
gold nanorods (GNRs) for two-photon luminescence imaging of cancer cells. Nanotechnology, 2010, 21(28),
Article Number: 285106.
22) S. Mahajan, I. Roy, G. Xu, KT. Yong, H. Ding, R. Aalinkeel, J. Reynolds, et al. Enhancing the delivery
of antiretroviral drug "Saquinavir" across the blood brain barrier using nanoparticles. Current HIV Research.
2010, 8(5): 396-404
23) KT. Yong, I. Roy, R. Hu, H. Ding, H. Cai, J. Zhu, et al. Synthesis of ternary CuInS2/ZnS quantum dot
bioconjugates and their applications for targeted cancer bioimaging. Integrative Biology, 2010, 2(2-3):
121-129.
24) R. Kumar, H. Ding, R. Hu, et al. In vitro and in vivo optical imaging using water-dispersible,
noncytotoxic, luminescent, silica-coated quantum rods. Chemistry Material. 2010, 22, 2261-2267
25) R. Hu, KT. Yong, H. Ding, PN. Prasad, S. He. Tunable multicolored hybrid metallic nanoparticles for
live human cancer cell imaging. Journal of nanophotonics. 2010, Volume: 4. Article Number: 041545
26) A. Bonoiu, S. Mahajan, H. Ding, I. Roy, KT. Yong, R. Kumar, R. Hu, EJ. Bergey, S. Schwartz, PN.
Prasad. Nanotechnology approach for drug addiction therapy: Gene silencing using delivery of gold
nanorod-siRNA nanoplex in dopaminergic neurons. Proceedings of the National Academy of Sciences of
the United States of America (PNAS-USA). 2009, 106(14): 5546-5550. (Highlighted by Nature
Nanotechnology (9 April 2009) and other professional media)
27) S. Mahajan, R. Aalinkeel, J. Reynolds, B. Nair, Z. Hu, A. Bonaiu, H. Ding, PN. Prasad, SA. Schwartz.
Therapeutic targeting of “DARPP-32”: A key signaling molecule in the dopiminergic pathway for the
treatment of opiate addiction. New concepts of psychostimulants induced neurotoxicity. Book
Series: International Review of Neurobiology. 2009, 88:199-222
28) Y. Nie, ZR. Zhang, L. Li, K. Luo, H. Ding, Z. Gu. Synthesis, characterization and transfection of a novel
folate-targeted multipolymeric nanoparticles for gene delivery. Journal of Materials Science: Materials in
Medicine (2009), 20(9):1849-1857
29) KT. Yong, H. Ding, I. Roy, WC. Law, et al. Imaging pancreatic cancer using bioconjugated InP quantum
dots. ACS Nano. 2009, 3(3): 502-510
30) WC. Law, KT. Yong, I. Roy, H. Ding, R. Hu, W. Zhao, PN. Prasad. Aqueous- phase synthesis of highly
luminescent CdTe/ZnTe core/Shell quantum dots optimized for targeted bioimaging. Small. 2009,
5(11):1302-1310
31) R. Hu, KT. Yong, I. Roy, H. Ding, S. He, PN. Prasad. Metallic nanostructures as localized plasmon
resonance enhanced scattering probes for multiplex dark-field targeted imaging of cancer cells". Journal of
Physical Chemistry-C. (2009), 113(7): 2676-2684
32) K. Yong, I. Roy, H. Ding, EJ. Bergey, PN. Prasad. Biocompatible near-infrared quantum dots as
ultrasensitive probes for long-term in vivo imaging applications. Small. 2009, 5(17): 1997-2004
33) K. Yong, MT. Swihart, H. Ding, PN. Prasad. Preparation of gold nanoparticles and their applications in
anisotropic nanoparticle synthesis and bioimaging. Plasmonics. 2009, 4(2):79-93
34) L. Liu, H. Ding, D. Liu, Q. Lu, S. Rousseaux, F. Wu. Design of oligonuleotide probes for cancer-testis
(CT) genes for cancer diagnosis microarray, Journal of Sichuan University, medical science edition, 2009,
40 (2):330-333, 336
35) KT. Yong, R. Hu, I. Roy, H. Ding, L. Vathy, EJ. Bergey, et al. Tumor targeting and imaging in live
animals with functionalized semiconductor quantum rods. ACS Applied Materials & Interfaces. (2009),
1(3):710-719
36) A. Bonoiu, SD. Mahajan, L. Ye, R. Kumar, H. Ding, KT. Yong, et al. MMP-9 gene silencing by a
quantum dot-siRNA nanoplex delivery to maintain the integrity of the blood brain barrier. Brain Research.
2009, 1282:142-155.
37) WC. Law, K. Yong, I. Roy, G. Xu, H. Ding, EJ. Bergey, et al. Optical and magneticcally modified silica
nanoparticles efficient magnetically guided biomarkers for confocal and two photon imaging of cancer cell.
Journal of Phyisical Chemistry-C. 2008, 112(21): 7972-7977
38) G. Xu, KT. Yong, I. Roy, H. Ding, PN. Prasad. Functionalized quantum rods as targeted probes for
transmigration across the blood brain barrier. Bioconjugate Chemistry. 2008, 19(6): 1179-1185
39) H. Alvarez, PL. Rojas, K. Yong, H. Ding, G. Xu, PN. Prasad, et al. Mesothelin is a specific biomarker of
invasive cancer in the Barrett-associated adenocarcinoma progression model: translational implications for
diagnosis and therapy. Nanomedicine: nanotechnology, biology, and medicine. 2008, 4(4): 295-301
40) H. Ding, KT. Yong, I.Roy, HE. Pudavar, WC. Law, EJ. Bergey, PN. Prasad. Gold nanorods coated with
multilayer polyelectrolyte as contrast agents for multimodal imaging. Journal of Physical Chemistry-C.
2007, 111(34): 12552-12557
41) ZX. Yuan, X. Sun, T. Gong, H. Ding, Y. Fu, ZR. Zhang. Randomly 50% N-acetylated low molecular
weight chitosan as a novel renal targeting carrier. Journal of Drug Targeting, 2007, 15(4): 269–278
42) H. Ding, F. Wu, Y. Huang, ZR. Zhang, Y. Nie. Synthesis and characterization of temperature- responsive
copolymer of PELGA modified poly(N-isopropylacrylamide). Polymer, 2006, 47(5): 1575-1583.
43) F. Wu, ZR. Zhang, H. Ding. Simple high-performance liquid chromatographic method for the
determination of Tetramethylpyrazine phosphate in very small volumes of dog plasma: application to a
pharmacokinetic study. Journal of Chromatographic Science, 2006, 44(1): 13-17.
44) F. Wu, H. Ding, ZR. Zhang. Investigation of the in vivo desintegration and transit behavior of
tetramethylpyrazine phosphate pulsincap capsule in the GI tract of dogs by gamma scintigraphy. Journal of
Biomedical Engineering, 2006, 23(4): 790-794
45) F. Wu, ZR. Zhang, H. Ding. Preparation of novel impermeable capsule bodies for pulsatile drug delivery
device. West China Journal of Pharmaceutical Sciences. 2006, 21(1): 5-7
46) H. Ding, F. Wu, ZR. Zhang. Synthesis of 6-methylpyridine-3-carbaldehyde. Chinese Journal of
Pharmaceuticals, 2005, 36(5): 266-267
47) H. Ding, JZ. Shen, F. Wu. A novel improved synthesis of 2-(2-aminoethyl)-1,3- dioxolane. Chinese
Journal of Pharmaceuticals, 2003, 34(2): 63-64
48) H. Ding, F. Wu. The application of DSC in the pharmaceutical research. World Notes on antibiotics,
2002, 23(5):193-196
49) H. Ding, LS. Wu, Y. Chen. A review on the study and development of four semi-synthetic and total
synthetic “Statin” drugs. Progress in Pharmaceutical Sciences. 1999, 23(2): 65-71
50) MR. Wang, H. Ding, YJ. Hu. Study on the role of Arginine and Valine in the biosynthesis of Teicoplanin.
Chinese Journal of Antibiotics. 1996, 23(suppl.): 77-80
51) H Liu, HC. Pan, H. Ding, XL. Wang. Study on the immobilization of nuclease P1. Food and
Fermentation Industries.1994, No. 4: 44-48
D.2 Submitted/Composed manuscripts:
52). JL. May, F. Erogbogbo, CA Tien, CW Chang, KT Yong, H. Ding, WC Law, PN. Prasad, MT. Swihart. A
Comparative Study of Water Dispersible Silicon Quantum Dot Formulations. Journal of Materials Research,
2012
53). Y. Nie, L. Ji, H. Ding, S. Chang, L. Xie, M. Li, L. Li, B. He, Y. Wu, ZW Gu. Cholesterol derivatives
based charged liposomes for doxorubicin delivery: preparation, in vitro and in vivo characterization.
Theranostics, 2012.
54) H. Ding, F. Wu, MP Nair. Image-guided drug delivery to brain by nanotechnology. Theranostics, 2012.

D.3 Patent
H. Ding, JZ. Shen, WH. Du. A novel procedure to synthesize Rosuvastatin and its intermediate and its
pharmaceutical salts. Chinese Invention Patent: CN1763015.

D.4 Book Chapter
F. Wu, H. Ding, ZR. Zhang. “mAb mediated DDS for lymphatic targeting treatment”, in book “Antibody
Mediated Drug Delivery Systems: Concepts, Technology and applications”. John Willey and Sons, 2012,
Chapter 9: p.169-190.

E. COMMUNITY ACTIVITIES
Invited as reviewers for 28 leading journals as:
1) Acta Physico-Chimica Sinica;
2) Analyst;
3) Biomedical Materials;
4) Biomaterial Sciences;
5) Chemical Communications;
6) Chemical Research in Toxicology;
7) Chemical Society Review;
8) Dalton Transactions;
9) Green Chemistry;
10) Integrative Biology;
11) International Journal of Nanomedicine;
12) Journal of Environmental Monitoring;
13) Journal of Materials Chemistry;
14) Journal of Medicinal Chemistry;
15) Lab on a Chip;
16) Medicinal Chemistry Communications;
17) Molecular BioSystems;
18) Nanotechnology;
19) Nanotechnology, Science and Application;
20) New Journal of Chemistry;
21) OncoTargets and Therapy;
22) Organic & Biomolecular Chemistry;
23) Plasmonics;
24) Polymer Chemistry;
25) Results in Pharma Sciences;
26) RSC Advances;
27) Soft Matter;
28) Theranostics.

Guest Editor for: Theranostics

Source: http://medicine.fiu.edu/_assets/docs/faculty-cv/immunology/Hong-Ding-CV.pdf