February 2005, volume 11 no 2

February 2005, Volume 11 No 2

Editorial
Structural integrity p103 News Researchers probe the real effect of placebos p105 Alla Katsnelson Tobacco money sparks squabble at California universities p106 Charlotte Schubert Spain launches cancer research project p106 Xavier Bosch Iressa's fall from grace points to need for better clinical trials p107 Emily Singer Logistical hurdles slow California's lofty stem cell scheme p107 Jonathan Knight 'Sumo' rats set researchers on hunt for obesity genes p108 K. S. Jayaraman Scientists irked by ethicists' alternatives for embryo research p108 Tinker Ready News In Brief p109 Profile: Susan Hockfield p110 Tinker Ready News Feature: The big picture pp111 - 112 Alan Dove Book Reviews Top Through the glass ceiling pp113 - 114 Reviewed by: Sharon G Levin Combating HIV p114 Reviewed by: Josh Ruxin News and Views Viagra: now mending hearts pp115 - 116 Michael E Mendelsohn Stressed and depressed pp116 - 118 Huda Akil ACE sets up fertilization pp118 - 119 Pierre Corvol A Toll-like trigger for autoimmune disease pp120 - 121 Jean-François Bach Picking apart plaques p121 Charlotte Schubert Cholesterol, racial variation and targeted medicines pp122 - 123 Eric J Topol Staying in SHIP shape pp123 - 124 Stuart J Decker & Alan R Saltiel Research Highlights p125 Brief Communication The breast cancer resistance protein BCRP (ABCG2) concentrates drugs and carcinogenic xenotoxins into milk pp127 - 129 Johan W Jonker, Gracia Merino, Sandra Musters, Antonius E van Herwaarden, Ellen Bolscher, Els Wagenaar, Elly Mesman, Trevor C Dale & Alfred H Schinkel Articles Re-engineered CD40 receptor enables potent pharmacological activation of dendritic-cell cancer vaccines in vivo pp130 - 137 Brent A Hanks, Jianghong Jiang, Rana A K Singh, Weitao Song, Michael Barry, Mary H Huls, Kevin M Slawin & David M Spencer Toll-like receptor engagement converts T-cell autoreactivity into overt autoimmune disease pp138 - 145 Karl S Lang, Mike Recher, Tobias Junt, Alexander A Navarini, Nicola L Harris, Stefan Freigang, Bernhard Odermatt, Curdin Conrad, Lars M Ittner, Stefan Bauer, Sanjiv A Luther, Satoshi Uematsu, Shizuo Akira, Hans Hengartner & Rolf M Zinkernagel Experimental autoimmune encephalomyelitis repressed by microglial paralysis pp146 - 152 Frank L Heppner, Melanie Greter, Denis Marino, Jeppe Falsig, Gennadij Raivich, Nadine Hövelmeyer, Ari Waisman, Thomas Rülicke, Marco Prinz, Josef Priller, Burkhard Becher & Adriano Aguzzi Spontaneous fetal loss caused by placental thrombosis in estrogen sulfotransferase—deficient mice pp153 - 159 Ming Han Tong, Hong Jiang, Ping Liu, John A Lawson, Lawrence F Brass & Wen-Chao Song Angiotensin-converting enzyme is a GPI-anchored protein releasing factor crucial for fertilization pp160 - 166 Gen Kondoh, Hiromasa Tojo, Yuka Nakatani, Nobuyasu Komazawa, Chie Murata, Kazuo Yamagata, Yusuke Maeda, Taroh Kinoshita, Masaru Okabe, Ryo Taguchi & Junji Takeda Accelerated re-epithelialization in beta3-integrin-deficient- mice is associated with enhanced TGF-beta1 signaling pp167 - 174 L E Reynolds, F J Conti, M Lucas, R Grose, S Robinson, M Stone, G Saunders, C Dickson, R O Hynes, A Lacy-Hulbert & K Hodivala-Dilke Deletion of Cdkn1b ameliorates hyperglycemia by maintaining compensatory hyperinsulinemia in diabetic mice pp175 - 182 Tohru Uchida, Takehiro Nakamura, Naoko Hashimoto, Tomokazu Matsuda, Ko Kotani, Hiroshi Sakaue, Yoshiaki Kido, Yoshitake Hayashi, Keiichi I Nakayama, Morris F White & Masato Kasuga Local and systemic insulin resistance resulting from hepatic activation of IKK-beta and NF-kappaB pp183 - 190 Dongsheng Cai, Minsheng Yuan, Daniel F Frantz, Peter A Melendez, Lone Hansen, Jongsoon Lee & Steven E Shoelson IKK-beta links inflammation to obesity-induced insulin resistance pp191 - 198 Melek C Arkan, Andrea L Hevener, Florian R Greten, Shin Maeda, Zhi-Wei Li, Jeffrey M Long, Anthony Wynshaw-Boris, Giuseppe Poli, Jerrold Olefsky & Michael Karin Absence of the lipid phosphatase SHIP2 confers resistance to dietary obesity pp199 - 205 Mark W Sleeman, Katherine E Wortley, Ka-Man V Lai, Lori C Gowen, Jennifer Kintner, William O Kline, Karen Garcia, Trevor N Stitt, George D Yancopoulos, Stanley J Wiegand & David J Glass Cathepsin L is required for endothelial progenitor cell−induced neovascularization pp206 - 213 Carmen Urbich, Christopher Heeschen, Alexandra Aicher, Ken-ichiro Sasaki, Thomas Bruhl, Mohammad R Farhadi, Peter Vajkoczy, Wolf K Hofmann, Christoph Peters, Len A Pennacchio, Nasreddin D Abolmaali, Emmanouil Chavakis, Thomas Reinheckel, Andreas M Zeiher & Stefanie Dimmeler Chronic inhibition of cyclic GMP phosphodiesterase 5A prevents and reverses cardiac hypertrophy pp214 - 222 Eiki Takimoto, Hunter C Champion, Manxiang Li, Diego Belardi, Shuxun Ren, E Rene Rodriguez, Djahida Bedja, Kathleen L Gabrielson, Yibin Wang & David A Kass Letter Uridine adenosine tetraphosphate: a novel endothelium- derived vasoconstrictive factor pp223 - 227 Vera Jankowski, Markus Tölle, Raymond Vanholder, Gilbert Schönfelder, Markus van der Giet, Lars Henning, Hartmut Schlüter, Martin Paul, Walter Zidek & Joachim Jankowski Technical Report Human embryonic stem cells express an immunogenic nonhuman sialic acid pp228 - 232 Maria J Martin, Alysson Muotri, Fred Gage & Ajit Varki Errata ERRATUM: Inhibitors of histone deacetylases induce tumor-selective apoptosis through activation of the death receptor pathway p233 A Insinga, S Monestiroli, S Ronzoni, V Gelmetti, F Marchesi, A Viale, L Altucci, C Nervi, S Minucci & P G Pelicci ERRATUM: Inhibition of respiratory syncytial virus infection with intranasal siRNA nanoparticles targeting the viral NS1 gene p233 W Zhang, H Yang, X Kong, S Mohapatra, H San Juan-Vergara, G Hellermann, S Behera, R Singam, R F Lockey & S S Mohapatra ERRATUM: The clock gene Per2 influences the glutamatergic system and modulates alcohol consumption p233 R Spanagel, G Pendyala, C Abarca, T Zghoul, C Sanchis-Segura, M C Magnone, J Lascorz, M Depner, D Holzberg, M Soyka, S Schreiber, F Matsuda, M Lathrop, G Schumann & U Albrecht

Source: http://www.governo.it/bioetica/pubblicazioni/Nature_medicine/2005/February.pdf