Das pharmakologische Profil von Sildenafil zeigt neben der PDE5-Inhibition auch eine geringe Aktivität an der PDE6 in der Retina. Dies erklärt visuelle Nebenwirkungen wie Farbsehstörungen, die gelegentlich auftreten. Die orale Bioverfügbarkeit beträgt etwa 40 %, mit einer hohen Bindung an Plasmaproteine. Das Verteilungsvolumen ist groß, sodass die Substanz rasch in verschiedene Gewebe gelangt. Die Metabolisierung erfolgt hepatisch und produziert einen aktiven Metaboliten, der die pharmakologische Wirkung ergänzt. Nebenwirkungen sind dosisabhängig und umfassen Kopfschmerzen, Hautrötung und Dyspepsie. Bei Vergleichen innerhalb der Wirkstoffklasse wird viagra original regelmäßig als Beispiel für eine Substanz mit schneller, aber kurzzeitiger Wirkung aufgeführt.

Epi-pen with self administration form

SOUTH BRUNSWICK BOARD OF EDUCATION
Emergency Health Care Plan and Medication Orders for Life Threatening Allergies
Student Name: ___________________________________________________ Date of Birth: ______________________ School year: _______________________ School: _________________________________________________________ Grade: _________________ Unit/Teacher: _________________________________ Allergy to: _____________________________________________________________________________________________ Asthmatic: Yes / No___
STEP 1: TREATMENT – to be completed by Physician
Symptoms:
Give Checked Medication
(to be determined by physician)
If exposure to an allergen occurs, but no symptoms Epinephrine
Antihistamine
 Mouth Itching, tingling, or swelling of lips, tongue, mouth Epinephrine
Antihistamine
 Skin Hives, itchy rash, swelling of the face or extremities Epinephrine
Antihistamine
 Gut Nausea, abdominal cramps, vomiting, diarrhea Epinephrine
Antihistamine
 Throat* Tightening of throat, hoarseness, hacking cough Epinephrine
Antihistamine
 Lungs* Shortness of breath, repetitive coughing, wheezing Epinephrine
Antihistamine
 Heart* Weak or thready pulse, low blood pressure, fainting, pale, blueness Epinephrine
Antihistamine
 Other* ___________________________________________________ Epinephrine
Antihistamine
 If reaction is progressing (several of the above areas affected), give: Epinephrine
Antihistamine
* Potentially life-threatening. The severity of symptoms can quickly change.
Epinephrine - inject intramuscularly (circle one):
Epi-pen 0.3 mg
Epi-pen Jr. 0.15 mg _____________________________________________
Antihistamine - give (medication/dose/route): _____Benadryl_______________mg__________________________________________________________________
Repeat Epi-Pen _____Yes_____/_____No_____ in 15 minutes if squad has not arrived - 2 kits will be needed in school.
STEP 2: EMERGENCY CALLS – to be completed by Parent/Guardian
1. Call 911 for Rescue Squad and ask for Advanced Life Support -state that an allergic reaction has been treated.
Mother: Home: __________________________________ Work: __________________________________ Cell: ________________________________ Father: Home: ___________________________________Work: __________________________________ Cell: _______________________________ First: Name: __________________________________ Relationship: ______________________________ Number: _____________________________ Second: Name: ________________________________ Relationship: ______________________________ Number: _____________________________ 3 Physician __________________________________________________________________ Phone: __________________________________________________ 4. Preferred Hospital ___________________________________________________________ Phone: ___________________________________________________ SELF ADMINISTRATION
I understand and agree that my child/patient requires the administration of epinephrine or a unit dose of benadryl in conjunction with epinephrine when exposed to a specific
allergen and he/she is capable of self-administration of the medication. Yes / No .
DESIGNEES
I understand that the school nurse, when available, is responsible for emergency care to my child/patient. In the absence of the school nurse, the nurse can designate and train
another staff member to administer one or two Epi-pens Yes / No_ . Benadryl can not be given by any designee.
CARRYING MEDICATION
I understand that on a trip, my child/patient may carry their own Epi-pens and Benadryl. Yes / No .
BEFORE AND AFTER SCHOOL PROGRAM
This Emergency Plan and Medication Order may be used in the before and/or after school programs __ Yes ___ /___ No ___/__ Not applicable __.
I hereby acknowledge that the South Brunswick Board of Education, its agents and employees shall incur no liability as a result of any injury arising from the administrationof a pre-filled, single dose auto-injector mechanism containing epinephrine to my child, and agree to indemnify and hold harmless the district, its employees and its agentsagainst any claims arising out of the administration of a pre-filled, single dose, auto-injector mechanism containing epinephrine.
First Parent/Guardian (circle one) Signature: ___________________________________________________________________ Date: _____________________
Second Parent/Guardian (circle one) Signature: _________________________________________________________________ Date: _____________________
School Nurse’s Signature: ____________________________________________________________________________________ Date: ______________________ Physician’s Signature and Stamp: __________________________________________________ Date: ____________________

Source: http://www.sbschools.org/our_schools/programs/health/docs/epi-pen_with_self_administration.pdf