April, 1997

CURRICULUM VITAE - Samuel N Heyman M.D.
Personal Details Place & date of birth: Tel Aviv, Israel, November 5, 1949. Citizenship : Israeli, I.D. # 03031613-7 Home address: 11 Sheshet Hayamim st. POB 1575, Mevasseret Zion, 90805. Working address: Dept. of Medicine, Hadassah Hospital, Mt. Scopus Phone: Home 02-5343563; Work 02-5844111; Mobile 050-7874289 Israel: Certified specialist in Internal Medicine (LN 8871) Israel: Certified specialist in Emergency Medicine (LN 19788) Military rank: Colonel (active reserves) Higher Education and Professional Experience: Hebrew University Hadassah Medical School, Jerusalem Internship at the Sheba Medical Center, Tel Hashomer Military service as a medical officer, Israeli Defence Forces (I.D.F.) Part time family practitioner in rural settlements in the Jordan Valley. Specialized in internal medicine at the Hadassah University Member, I.D.F./Governmental Israeli medical delegation to Cambodian refugee camp, Sakeo, Thailand. Service in the I.D.F. as a senior medical officer (lieutenant colonel). Head of the Emergency Services, in charge of the Medical and Hematological Day Care Unit and an attending senior physician in the Department of Medicine in the Hadassah University Hospital, Mt Scopus, Jerusalem. Member, the Israeli Army medical relief team to Soviet Armenia. Research fellow in Medicine, Harvard medical School, Boston (renal pathophysiology, see below) Service in the Israel Defense Forces. In charge of the medical systems in the Northern Command (full colonel). Senior physician, Department of Medicine, Hadassah University Hospital, Mt. Scopus, Jerusalem M.A.S.H. Commander, IDF mission for Rwandan refugees, Goma, Zaire. Active Head of the Department of Medicine, Hadassah University Hospital, Mt. Scopus, Jerusalem (8 months). Team-head, medical relief operation, Northern Wollo, Ethiopia (Jewish Agency) Medical Director, Bayer House for the Aged (a 200-beds nursing home) Appointments at the Hebrew University: Instructor of Medicine, Hebrew University Hadassah Medical School, Jerusalem. Lecturer of Medicine, Hebrew University Hadassah Medical School, Jerusalem. Senior Lecturer, Hebrew University Hadassah Medical School, Jerusalem. Associated Professor of Medicine, Hebrew University Hadassah Medical Professor of Medicine, Hebrew University Hadassah Medical School, Jerusalem Additional Functions/Tasks at the Hebrew University (since last promotion): 1999-2002 Course Director: Introduction to Clinical Medicine (1st year in clinical clerkship, Medical School)[course No. 96713] Buildup and Course Director: Problem Based Learning (PBL)(1st year of clinical clerkship, Medical School)[new section of course No. 96713] Course director: Health Promotion (Master’s degree in Nursing, Hebrew University)[course No. 93113] Head, Academic Division of Internal medicine and sub-specialties, the Hebrew University Medical School Member, Clinical Education Committee, the Hebrew University Medical Service in other Academic and Research Institutions: 1989-1991 Research fellow, Dana research institute, Department of Medicine and the Harvard Center for the Study of Kidney Diseases, Harvard Medical School and Beth Israel Hospital. Other Activity: Academic: May 2002 Moderating a Consensus Conference about animal models of acute renal failure: the Acute Dialysis Quality Initiative (ADQI) meeting, Vicenza, Italy, May 2002 Co-moderating (with MA Venkatachalam) a Consensus Discussion - In Vitro and In Vivo Systems, in the American Society of Nephrology-Acute Renal Failure Retreat, June 2004, Washington, D.C. Abstract Review Category Chair - Pathophysiology of Renal Disease: Acute Renal Failure, Basic. The American Society of Nephrology (ASN) annual meeting, 2005 Co-moderating free communication session "Novel Mediators and Therapeutic Targets in ARF", The American Society of Nephrology (ASN) annual meeting, Nov 2005, Philadelphia. 2004-current Faculty member, Faculty of 1000, Medicine (Nephrology – Acute Renal Abstract reviewer – Category - Pathophysiology of Renal Disease: Acute Renal Failure, Basic. The American Society of Nephrology (ASN) annual meeting, 2007 Directing teaching functions in Hadassah Medical organization as a teaching Hospital 1986-1989 Head, Dept. Of Emergency Medicine, Hadassah Mt. Scopus Active Head, Dept. of Medicine, Hadassah Mt. Scopus Medical director, Bayer Institute for the Aged (medically run by Hadassah Medical personnel) Chairman, Emergency Hospitalization authority, Israeli Northern Command, Ministry of Health. Member, the University Institute of Post-graduate Medical Education, Hebrew University - Hadassah Medical School. Member, the Institutional Committee for Termination of Pregnancies. Director, the Project of Development of the Emergency Services, Hadassah Hospital, Mt. Scopus. Member, the Institutional Committee for Postgraduate Medical Training 2000-current Member, the Institutional Research Committee 2002-current Member, the Institutional Committee of Clinical Clerkship 2007-current Member, the Institutional Committee of Emergency Medicine Services 2007-current Member, the Institutional Committee of the Dying Patient policies Reviewing of manuscripts and grants
I have reviewed over 40 manuscripts during the last 4 years, submitted to various
journals, including J Am Soc Nephrol (6), Kidney Int (13), Am J Physiol (5), Nephrol
Dial Transpl (3), Exp Nephrol, Am J Kid Dis, Drugs, Nephron, Am J Hypertens, Exp
Opin Pharmacol, Clin Exp Pharmacol Physiol, Diabetologia, etc. I also served as a
grant reviewer for BSF and TWAS program.

Membership in academic societies:
1973-current Israeli Medical Association
1986-9
American Association of Emergency Medicine 1993-current Israeli Council of Emergency Medicine 1995-current Israeli Society of Internal Medicine 1996-current Israeli Society of Toxicology 1997-current American Society of Nephrology 2005-current Israeli Society of Nephrology Research Grants: Competitive grants 1996-1997 The Chief Scientist, Ministry of Health, Israel: The role of outer medullary hypoxia in endotoxin-induced acute renal failure (PI) ($9,000) #39, #40 The Chief Scientist, representing The Israeli Fund of Legacies: Nephrotoxicity of COX-2 inhibitors (PI) ($10,000) #42 The Israeli Society of Nephrology: Nephrotoxicity of COX-2 inhibitors (PI) ($3,000) #42 The Hadassah Compensatory Fund: Renal protection by PARP inhibition (PI) ($8,000) #48 The Chief Scientist, Ministry of Health: Acute Renal Failure Following Open Heart and Aortic Surgery: Is N-Acetylcysteine Renoprotective? (PI, together with Dr Dganit Dinour, Shiba Medical Center ($16,000) (Multicenter study eventually stopped due to small numbers of patients enrolled) Grant from The Harvard Medical Faculty Physicians at Beth Israel Deaconess Medical Center, Boston, MA. (PI) ($17,000) #51,52,53,55,56,57,58,59 D-CURE grant: Diabetes Predisposes to Acute Tubular Necrosis: A Role For Medullary Hypoxic Damage? (PI) ($116,000) # 57,58,59, Abstracts #78,87 Israeli Science Foundation: Regional renal hypoxia and hypoxia adaptive response in diabetes: risk factors for chronic and acute renal failure (PI, together with Dr. Mogheir Khamaisi) ($160,000) Grants/research support provided by scientific industry

2000-2001
Guilford Pharmaceutical Co., Baltimore USA. Novel PARPP inhibitors: protective effect in ATN (PI) ($16,000) # 48 MTR Co. Israel. The effect of MTR-105 on intrarenal hemodynamics (PI)($700) N.S.T. Co. Petach Tikvah, Israel, Detection of renal tubular apoptosis/ necrosis with ApoSense (CI) ($2000) #55 FibroGene, San Francisco, CA, USA. The use of prolyl-hydroxylases inhibitors in the prevention of renal hypoxic injury: studies in the isolated perfused kidney (PI)($ 15,000) Peptide Therapy/Immunity Pharma ( a Weizmanm-related startup company) The use of p53 inhibitors in the prevention of acute tubular necrosis. Studies in-vivo (PI, $3000)
Consultant for commercial bio-industry
2007 – Minerva LTD, Misgav Biotechnology. Development of solutions for cryo-
preservation
2008 – Inotek Pharmaceutical Corp, Beverly, MA – novel antioxidants/NO donors
in the prevention of acute kidney injury renal injury
2008 – Noorik GmbH, Rüchligweg 55, 4125 Riehen, Switzerland – The use of
selective ET antagonists in the prevention of radiocontast nephropathy.
Teaching at the Hebrew University:
Baha N Francis: Renal ETA and ETB receptors in congestive heart failure. (assisting tutoring by Zaid Abassi, the Rapaport Medical School, Technion)(2004) #50 Vitali Shiloh: Diabetes, ECE and predisposition to ATN (co-supervisor Dr. Mogher Khamaisi) (2005-2006) Abstract #87 Liat Ustinov: The effect of radiocontrast agents on ECE and endothelin synthesis. (co-superviser with Dr Mogher Khamaisi and Prof. Itamar raz)(2006-) Ronit Greenbaum: The role of acidosis in myoglobinuric renal failure – studies in isolated perfused kidneys (co-supervisor Prof. Mayer Brezis)(1994) #29 Shlomo Cohen: The effect of chronic COX-2 inhibition on renal function and structural integrity: studies in rats (1998) #42 Ravit Yanko: The role of nitric oxide in renal hemodynamic response to hyperglycemia (co-supervisor Prof. Itamar Raz)(2000) Soheir Hanna: The effect of the fibrinolytic system on intrarenal Hemodynamics (excellence prize)(2003) #51 Nimrod Maril: Renal sodium MRI during ARF. (Assisting project directed by Prof. Hadassa Degani, Weizmann Institute of Science) (2003-4) #56 Basic Science required for specialty in Internal Medicine Shmuel Fuchs: Renal effects of IGF-1 (co-supervisor Prof. Mayer Brezis)(1993)#30 James Reichman: Renal effects of selective COX-2 inhibition (1998) #42 Helena Bitz: Experimental pyelonephritis (1999) #41 David Darmon: Experimental pyelonephritis, endotoxic renal failure, inhibition of PARP system in the the prevention of ARF (1997-2002) #39,40,41,48 Marina goldfarb: Experimental pyelonephritis, Selective COX-2 inhibition, endotoxic renal failure, heart failure predisposes to ATN, mechanisms and modulation of renal interstitial fibrosis, renal protective effects of PARP and NAC, renal effects of nicotine, acute on chronic kidney failure, EPO in the prevention of radiocontrast nephropathy (1997-current) #39,40,41,42,44,47,48,53,57,59 Yael Netz (sports physiology and physiotherapy, Wingate Institute): Promoting physical activity in incapacitated geriatric patients in a nursing home (2003-4) #60
COURSES GIVEN/DIRECTED
Clinical teaching:
I provide bedside clinical teaching and small group lectures to 4th and 6th years
medical students during their clerkship in Medicine (courses # 96709, 96845). I also
participated in small group physical examination courses, and in the PBL course (both
related to the Introduction to Clinical Medicine, course # 96713).
For several years I also deliver the frontal lectures on Patient's Interview, Patient's
Admission, and Principals of Problem-Oriented Medicine in the "Introduction to
clinical Medicine" for 4th year medical students (course # 96713), this year as part of
the new frontal course of Clinical Examination.
I participate every year in graduates' oral examinations in Medicine in the 6th year
(#96910). This is preceded by my very active role in a non-official set of workshops,
simulating these final oral examinations.
I also participate in teaching in the Nursing School and School of Pharmacology in the
Hadassah Medical School, and in additional small-scale teaching projects.
Altogether, I provide almost 200 teaching hours a year for students during all these
activities, some 175 of which are dedicated to medical students. Not counted are
numerous teaching hours I give to trainees in Internal Medicine, Family practitioners,
nursing staff and others during my daily clinical activities.

Organizing activities:
During 1999-2002 I directed the 4th year Introductive Course of Clinical Medicine
(course #96713). Subsequently, I planned, built and directed for 2 years the new 4th
year Problem Based Learning (BPL) course (related to the Introduction to Clinical
Medicine course, #96713). This project included writing and editing all 12 PBL cases
currently in use (a 3 months full-time project). This course gained, to my knowledge,
the highest scores, ever, in the Hebrew University Medical School (see list of
publications, a submitted manuscript), and I am still involved in its conduction, both
as a tutor and by running yearly the tutors' guidance course, together with Prof. Robert
Cohen. Attached is the former Dean's (Prof. Shoval's) letter, dated Jan 21, 2004,
acknowledging my contribution in the buildup and implementation of this new
successful educational program.
Since 2003 I serve as the Chairman of the Clinical Academic Division of Internal
Medicine. A major change I have initiated during that period is the re-arrangement of
the preclinical period in the 4th year, reforming the basic course of Clinical
Examination, a very problematic clinical course for many years. This change just took
place, after 2 years of preparations, involving the creation of a totally new scheme, to
a large extent based on audio-visual facilities that were purchased or generated in the
faculty. Preliminary assessment of the course is encouraging.
I also currently participate as a member of few institutional and academic Committees
including Clinical Clerkship for Trainees, Evaluation of Clinical Teaching, and others.

Other academic teaching activities, domestic and abroad:
I participate in teaching activities as a member in the Israeli Associations of
Emergency Medicine and of Toxicology and in the American Society of Nephrology
(see letter of recognition by Dr. Berl, the former Chairman of the American Society of
Nephrology). I often take part in the national final certification examinations in
Medicine and occasionally serve as a referee in thesis presentations in other academic
institutions.


Excellent Teacher (Dean's list) 2000, 2001, 2002, 2004 Excellent Thesis Work by instructed student (Zoheir Hana, MD work, 2003) I was introduced to basic research in renal physiology by two excellent teachers, Prof.
mayer Brezis in the Hebrew University Medical School and Prof. Franklin Epstein in
Harvard, Boston, and have been active as an independent researcher for over 12 years.
During that time I have been collaborating with researchers both in Israel (Itamar Raz,
Mogheir Khamaisi, Haj Ihia Abdallah, Abd Al Roof Higazi, Dani Rachmilewitz and
Rami Eliakim, all in Hadassah and the Hebrew university medical School and School
of Pharmacy; Zaid Abassi, the Technion Rappaport Faculty of Medicine; Nimrod
maril and Hadassah Degani, Weizmann's institute; Deganit Dinour, Shiba Hospital;
and researchers in a few start-up companies) and abroad (Christian Rosenberger,
Virchow, Berlin; Kai Eckhardt, Erlangen-Nuremberg; Seymour Rosen, Harvard,
Boston, and scientists from a few start-up private companies).
My main basic research involves the study of the pathophysiology of acute renal
failure, and in particular of radiocontrast nephropathy. My basic studies and
communications contributed much to the development of clinically relevant animal
models of ATN, based on the now well accepted concept of the multifactorial nature
of this disorder, with the application of multiple predisposing manipulations that
mimic the human syndrome, needed for the development of ARF. This concept gained
momentum following expert opinion councils about animal models of ARF which I
chaired or co-chaired, conducted by the critical care ADQI initiative and by the ASN
leadership (Review articles #13,16,18). Consequently I was recently honored to write
a review chapter about animal models of acute kidney injury in the forthcoming new
edition of Critical Care Nephrology edited by Bellomo and Ronco. Many leading
researches in this field have adopted this concept and now complement their widely
used faulted ischemia-reflow models, with the generation of background risk factors
in newly developed multi-insult clinically relevant animal models.
In that perspective I have created one of the first clinically relevant models of acute
hypoxic distal nephrons injury in salt depleted uninephrectomized rats treated with
NSAIDs (JCI, 1988, #4), and participated in later developments and ramifications of
this model, including knockout of NOS (#8), ureteral obstruction (#28),
rhabdomyolysis (#27), endotoxemia (#40), etc. These research projects also
established the concept of the central role of medullary hypoxemia in the
development of ATN (reviews #9,10,19,20) that has been previously suggested in
studies in the isolated perfused kidney, formerly performed by Mayer Brezis, Franklin
Epstein and Seymour Rosen. This concept has recently been further established by
novel methods for the detection of hypoxia, hypoxia response and cell death (see
below).
In studying the pathophysiology of radiocontrast nephropathy, I was the first to show
that contrast agents induce endothelin release in vivo and in vitro, and have studied its
effect on ANP release, on intrarenal NO concentration, and on intrarenal
microcirculation (#4,9,12,18,36). I have also studied experimentally various protective
measures in this disorder, including hydration, loop diuretics, acetylcysteine, PARPP
and erythropoietin (#5,17,47,48,59). I have also been studying extensively the
intrarenal microcirculation during various stimuli and mediators, including altered
systemic hemodynamics, endotoxemia, myoglobinuria, urine outflow obstruction
nicotine, dopamine and other agents (#24,25,17,28,31,37,39,41,42,47,49,51).
Main basic research projects since last promotion:
1. I conducted the first in vivo studies reported using special NO electrodes,
determining intrarenal NO content under different pathophysiologic conditions and its impact of intrarenal microcirculation (#31,36,37). In these experiments we found an inverse relation between ambient NO content and tissue oxygenation and suggested mechanistic explanations. 2. I explored the control and behavior of renal microcirculation under a variety of conditions, such as the administration of NSAIDs (#42), endotoxins (#39), acetylcysteine (#47), nicotine (# 53), and the modulation of the fibrinolytic system (#49,51), and the potential clinical relevance of these findings. 3. I demonstrated a role for medullary hypoxia in the pathogenesis of acute renal failure and tubular necrosis (ATN) during endotoxemia (#40), NSAID administration (#42), congestive heart failure (#44) and acute-on chronic renal failure (#57). 4. I participated with other groups in efforts to identify non-invasively evolving ATN in the setup of renal dysfunction. Such technologies are critically needed in the clinical practice, since currently it is impossible to identify at real time evolving tubular damage. We found that sodium MRI detection of the failure to build up sodium gradient in the renal medulla indicates evolving ATN (#56). We also found that ApoSense, a small molecule with affinity to apoptotic and necrotic tissue can successfully identify ATN and may serve as a potential non-invasive imaging probe for that purpose (#55). 5. In efforts to develop clinically relevant models of acute renal failure and ATN (see importance in reviews and editorials #12,#13,#16) I have recently developed the first true (other than following 4/5 renal ablation) acute-on-chronic renal failure model (#57). In this model for the first time the independent contribution of chronic and acute tubulointerstitial damage to evolving renal dysfunction has been explored, revealing unexpected findings that shed a new light on the assessment of this common clinical condition. 6. I am recently deeply involved in the understanding of the intrarenal mapping of evolving kidney tissue hypoxia under various insults, and the generation of hypoxic stress response genes via the activation of hypoxia-inducible factors (HIF). Using immunostaining and morphology in vivo and in isolated perfused kidneys, and in collaboration with German and American colleagues we found the precise location, cell types involved and timing of HIF activation and related gene expression in the kidney during hypoxic stress and evolving ATN (#52, #57, #58). We have studied HIF expression it transplanted human kidneys (#63), are currently studying the protective effect of HIF stabilizers in hypoxic isolated perfused kidneys, and will soon start evaluating the effect of a novel P-53 antagonist in ischemic renal injury. 7. I am currently studying intensively the role for renal parenchymal hypoxia in diabetic nephropathy and in the propensity of the diabetic kidney to develop renal dysfunction. I study the generation of tubulinterstitial damage during early experimental diabetes, and my recent studies both in vivo and in the isolated perfused kidney confirm the intensification of medullary hypoxic stress produced by chronic and acute hyperglycemia, and demonstrate adaptive stress response, mediated by HIF (abstracts #78, #87, manuscript submitted). These studies also illustrate improved HIF up-regulation with ROS scavenging in the diabetic kidney. They also reveal unexpected finding of a unique collecting duct injury pattern, not appreciated so far (abstract #87) 8. I continue to explore my favorite topic: the pathophysiology and prevention of radiocontrast nephropathy, providing mechanistic effects of acetylcysteine (47#), demonstrating a potential protective effect of PARPP inhibition (#48) and erythropoietin (#59), and demonstrating hypoxic stress response mediated through HIF following radiocontrast administration (#52) 9. I am also study the nature of endothelin up-regulation via ECE induction in diabetes and in radiocontrast nephropathy, in collaboration with Mogheir Khamaisi (manuscript to be submitted soon) and in the assessment of upregulation of endothelin ETB receptors in the renal medulla, (presumably an adaptive protective stress response) in congestive heart failure (#50), acute-on chronic renal failure (#57) and diabetes (abstract #78), in collaboration with Zaid Abassi. 10. I am about to resume collaboration with Hadassah Degani, once the human sodium MRI equipment is ready in Weizmann's institute, and to extend our preliminary findings in rodents (#56) using renal sodium MRI as a tool for the assessment of acute and chronic renal parenchymal diseases in humans. International acknowledgement of my Basic research: Over the years I became an
acknowledged figure in the research of the pathophysiology of acute renal failure, in
particular in the topics of contrast nephropathy, intrarenal microcirculation and
oxygenation, and animal models of acute renal failure. As detailed in the CV I am
invited to talk about these topics, to participate in international committees (forums
held the critical care-ADQI innitiative and by the American Society of Nephrology),
to write invited reviews and book chapters (including the contrast nephropathy chapter
in Schrier's textbook of nephrology and Bellomo/Ronco textbook of Critical Care
Nephrology), to take part as a head referee in abstracts' evaluation and a lecturer in a
postgraduate course (both by the American society of nephrology), and to participate
in the Faculty 1000 project. Enclosed please find a relevant acknowledgement letter
from Prof. Thomas Berl, the former president of the American Society of Nephrology,
dated Aug 18, 2005.
Clinical Research:
Though serving as a senior physician in a medical department, and medical director in
a big geriatric institute, emergency and disaster medicine remains my major clinical
interest since the time I was head of the Department of Emergency Medicine in
Hadassah Mt. Scopus. I am one of the founders of the Emergency Medicine specialty
in Israel, and have been involved in the planning and buildup of pre-hospital
emergency medical and evacuation systems in the Israeli Defense Forces, and in the
South Lebanese emergency medical system throughout my military career (last
position in regular service – Chief Medical Officer, Northern Command). I have
participated in a few medical relief operations in disaster settings over the years
(Cambodia, Armenia, Rwanda, Ethiopia) as a physician, and directed the Rwandan
and Ethiopian missions. Most of my clinical research projects relate to analysis of
these activities (#33,34,35,45). I have also recently participated in planning and
conducting of a few research projects in geriatric rehabilitation (#60) and in the
prevention of post cardiac surgery renal dysfunction (a multi-center project supported
by the Chief Scientist that was terminated for lack of participants due to the abrupt
recent decline in cardiac surgical procedures).
Research in Medical Education:
As outlined in the section of my academic activities, I am deeply involved in the
assessment of the efficacy and quality of medical education. As part of this interest
and activity I participated in the generation of the new concept by Benbassat of
teaching Directed Physical Examination (#54) and in the creation and evaluation of a
novel teaching technology termed "Short PBL Experience" in the Hebrew University Medical School (#62) LIST OF PUBLICATIONS

ARTICLES
1.
Shalev O, Heyman S, Hod G, Adato R. Chronic granulocytic leukemia in pregnancy: A case report and review of the literature. Acta Obstet Gynecol Scand, 59:563-565, 1980. Heyman S, Shalev O, Menczel J. The treatment of Paget's disease. Harefuah 99:438-439, 1980. (Hebrew) Heyman SN, Tobi M, Shalev O. Megaloblastic anemia in vegans. Harefuah 103:148-150, 1982. (Hebrew) Eliakim R, Heyman S, Korenberg A. Autoimmune thrombocytopenic purpura associated with celiac disease and keratoconjunctivitis sicca. Arch Intern Med 142;1037, 1982. Heyman S, Leor R, Halperin Y. Tetanus from machwa wounds. Harefuah 105:63-65, 1983. (Hebrew) Michaeli J, Mogle P, Perlberg S, Heyman S, Caine M. Emphysematous pyelonephritis. J Urology 131:203-208, 1984. Heyman SN, Michaeli J, Brezis M, Gozlan L, Lernau O. Primary hyperparathyroidism presenting as cervical myelopathy. Am J Med Sci 291:112-114, 1986. Brezis M, Heyman SN. Diversity of injuries in renal ischemia. Intern J Artificial Organs 9:7-8, 1986. Heyman SN, Brezis M. Renal medullary hypoxia; Physiological and pathophysiological implications. Harefuah 110:31-33, 1986. (Hebrew) 10. Heyman SN, Brezis M, Stessman J. Water and salt imbalance in the elderly. 11. Heyman SN, Stalnikovitch R, Heyman A, Gilon D, Mogle P. Erythromycin- induced dynamic ileus? J Clin Gastroenterol 10:551-554, 1988. 12. Heyman SN, Brezis M, Reubinoff CA, Greenfeld Z, Lechene C, Epstein F, Rosen S. Acute renal failure with selective medullary injury in the rat. J Clin Invest 82:401-412, 1988. 13. Heyman SN, Heyman A, Halperin I. Diabetogenic effect of nifedipine. DICP 14. Heyman SN, Brezis M, Perlberg S, Metzner Y. Bilateral hydronephrosis and erythrocytosis. Harefuah 117:358-360, 1989. (Hebrew) 15. Heyman SN, Brezis M, Greenfeld Z, Rosen S. Protective role of furosemide and saline in radiocontrast-induced acute renal failure in the rat. Am J Kidney Dis 14:377-385, 1989. 16. Heyman SN, Fink R, Benbassat Y. The emergency room as a setting for clinical training. Harefuah 119:141, 1990.(Hebrew) 17. Brezis M, Greenfeld Z, Herman M, Meyer JJ, Heyman SN, Rosen S. Experimental nephrotoxicity of the radiocontrast agents iohexol ioxagglate and iothalamate. An in vivo and in vitro study. Invest Radiol 26:325-331, 1991. 18. Heyman SN, Mevorach D, Ghanem J. Hypertensive crisis from chronic intoxication with nasal decongestant and cough medications. DICP 25:1068-1070, 1991. 19. Brezis M, Heyman SN, Dinour D, Epstein FH, Rosen S. Role of nitric oxide in renal medullary oxygen balance. Studies in isolated and intact rat kidneys. J Clin Invest 88:390-395, 1991. 20. Heyman SN, Brezis M, Epstein FH, Spokes K, Silva P, Rosen S. Early renal medullary hypoxic injury from radiocontrast and indomethacin. Kidney Int 40:632-642, 1991. 21. Heyman SN, Rosen S, Silva P, Spokes K, Egorin MJ, Epstein FH. Protective action of glycine in cisplatin nephrotoxicity. Kidney Int 40:273-279, 1991. 22. Heyman SN, Mammen M. Effect of indomethacin and salt depletion on renal proton MR imaging. An experimental study in the rat. Acta Radiol 32:524-525, 1991. 23. Heyman SN, Clark BA, Kaiser N, Spokes K, Rosen S, Brezis M, Epstein FH. Radiocontrast agents induce endothelin release in vivo and in vitro. J Am Soc Nephrol 3:58-65, 1992. 24. Heyman SN, Brezis M, Epstein FH, Spokes K, Rosen S. Effect of glycine and hypertrophy on renal outer medullary hypoxic injury in ischemia reflow and contrast nephropathy. Am J Kid Dis 19:578-586, 1992. 25. Heyman SN, Clark BA, Kaiser N, Epstein FH, Spokes K, Rosen S, Brezis M. In- vivo and in-vitro studies on the effect of amphotericin B on endothelin release. J Antimicrob Chemotherap 29:69-77, 1992. 26. Heyman SN, Spokes K, Rosen S, Epstein FH. Mechanism of glycine protection in hypoxic injury: analogies with glycine receptor. Kidney Int 42:41-45, 1992. 27. Stillman IE, Brezis M, Greenfeld Z, Ransil BJ, Heyman SN, Rosen S. Cyclosporine nephropathy: Morphometric analysis of the medullary thick limb. Am J Kid Dis 10:162-167, 1992. 28. Weinstein JM, Heyman SN, Brezis M. Potential deleterious effect of furosemide in radiocontrast nephropathy. Nephron 62:413-415, 1992. 29. Heyman SN, Epstein FH. Glycine and cytopreservation: disappointments and promises. J Lab Clin Med 121:199-200, 1993. 30. Heyman SN, Clark BA, Kaiser N, Cantley L, Spokes K, Rosen S, Brezis M, Epstein FH. Effects of ioversol vs iothalamate on endothelin release and radiocontrast nephropathy. Invest Radiol 28:313-318, 1993. 31. Heyman SN, Eilam O, Dinour D. The osmolar gap as a diagnostic tool in severe alcohol intoxication. Harefuah 124:408-410, 1993. (Hebrew) 32. Heyman SN, Spokes K, Egorin MJ, Epstein FH. Glycine reduces early renal parenchymal uptake of cisplatin. Kidney Int 43:1226-1228, 1993. 33. Heyman SN, Stillman LE, Brezis M, Epstein FH, Spokes K, Rosen S. Chronic amphotericin nephropathy: morphometric, electron microscopic and functional studies. J Am Soc Nephrol 4:69-80, 1993. 34. Brezis M, Heyman SN, Sugar AM. Reduced amphotericin toxicity in albumin vehicle. J Drug Targeting 1:185-9, 1993. 35. Heyman SN, Rosen S, Brezis M. Radiocontrast nephropathy: A paradigm for the synergism between toxic and hypoxic insults in the kidney. Exp Nephrol 2:153-157, 1994. 36. Stillman LE, Brezis M, Heyman SN, Epstein FH, Spokes K, Rosen S. Effects of salt depletion on the kidney: changes in medullary oxygenation and thick ascending limb size. J Am Soc Nephrol 4:1538-1545, 1994. 37. Heyman SN, Rosen S, Epstein FH, Spokes K, Brezis M. Loop diuretics reduce hypoxic damage to proximal tubules of the isolated perfused rat kidney. Kidney Int 45:981-985, 1994. 38. Heyman SN, Agmon Y, Brezis M. Radiologic contrast agents and hypoxic renal medullary injury. Harefuah 127:176-179, 1994. (hebrew) 39. Brezis M, Heyman SN, Epstein F. Determinants of intrarenal oxygenation: 2. Hemodynamic effects. Am J Physiol 267 (Renal Fluid Electrolyte Physiol 36):F1063-F1068, 1994. 40. Mevorach D, Heyman SN. Pain in the marriage. A clinical problem solving. N 41. Heyman SN, Adler S, Stewart B, Aviad I. Benign retropneumoperitoneum induced by emesis. J Clin Gastroenterol 20:88-90, 1995. 42. Heyman SN, Brezis M. Acute renal failure in glomerular bleeding. A puzzling phenomenon. Nephrol Dial Transplant 10:591-593, 1995. 43. Heyman SN, Kaminski N, Brezis M. Dopamine increases medullary blood flow without improving regional hypoxia. Exp Nephrol 3:331-337, 1995. 44. Heyman SN, Babayof I. Emphysematous complications in dentistry, 1960-1993: an illustrative case report and review of the literature. Quintessence Int 26:535-543, 1995. 45. Heyman SN, Fuchs S, Brezis M. The role of medullary ischemia in acute renal 46. Heyman SN, Rosen S, Fuchs S, Epstein FH, Brezis M. Myoglobinuric acute renal failure in the rat: A role for medullary hypoperfusion, hypoxia and tubular obstruction. J Am Soc Nephrol 7:1066-1074, 1996. 47. Heyman SN, Fuchs S. Yafe R, Beeri R, Elazarian L, Brezis M, Rosen S. Renal microcirculation and tissue damage during acute ureteral obstruction: the effect of saline infusion, indomethacin and radiocontrast. Kidney Int 51:653-63, 1997. 48. Heyman SN, Greenbaum R, Shina A, Rosen S, Brezis M. Myoglobinuric acute renal failure in the rat: a role for acidosis? Exp Nephrol 5:210-16, 1997. 49. Fuchs S, Yaffe R, Beeri R, Rosen S, Heyman SN, Brezis M. Failure of insulin- like growth factor 1 to improve radiocontrast nephropathy. Exp Nephrol 5:88-94, 1997. 50. Heyman SN, Karmeli F, Rachmilewitz D, Haj Yehia A, Brezis M. Intrarenal nitric oxide monitoring with a clark-type electrode: potential pitfalls. Kidney Int 51:1619-23, 1997. 51. Heyman SN, Karmeli F, Brezis M, Rachmilewitz D. The effect of ketotifen on nitric oxide synthase activity. Br J Pharmacol 120:1545-1551, 1997. 52. Heyman SN, Ginosar Y, Shapiro M, Kluger Y, Marx N, Maayan S. Diarrheal epidemics among Rwandan refugees, 1994: management and outcome in a field hospital. J Clin Gastroenterol 25:595-601, 1997. 53. Heyman SN, Rosen S, Brezis M. The renal medulla: Life at the edge of anoxia. 54. Heyman SN, Eldad A, Wiener M. Airborne field hospital in disaster area: Lessons from Armenia (1988) and Rwanda (1994). Prehosp Disaster Med 13:21-28, 1998. 55. Heyman SN, Ginosar Y, Niel L, Amir J, Marx N, Shapiro M, Maayan S. Meningococcal meningitis among Rwandan refugees: diagnosis, management and outcome in a field hospital. Int J Infect Dis 2:137-142, 1998. 56. Heyman SN, Goldfarb M, Karmeli F, Shina A, Rachmilewitz D, Brezis M. The effect of radiocontrast on intra-renal nitric oxide (NO) and NO synthase activity. Exp Nephrol 6:557-562, 1998. 57. Heyman SN, Goldfarb M, Darmon D, Brezis M. Tissue oxygenation modifies nitric oxide bioavailability. Microcirculation 6:199-203, 1999. 58. Heyman SN, Reichman J, Brezis M. The pathophysiology of contrast nephropathy: a role for medullary hypoxia. Invest Radiol 34:685-691, 1999. 59. Zlatkin S, Aamar S, Specter G, Simanovsky N, Leibowitz D, Yeshurun D, Heyman SN. Takayasu’s Arteritis identified by computerized tomography: revealing the submerged portion of the iceberg? IMAJ 1:245-249, 1999. 60. Heyman SN, Rosen S, Darmon D, Goldfarb M, Bitz H, Shina A, Brezis M. Endotoxin-induced renal failure: I. a role for altered renal microcirculation. Exp Nephrol 8:266-274, 2000. 61. Heyman SN, Rosen S, Darmon D, Goldfarb M, Bitz H, Shina A, Brezis M. Endotoxin-induced renal failure: II. a role for tubular hypoxic damage. Exp Nephrol 8:275-282, 2000. 62. Bitz H, Darmon D, Goldfarb M, Shina A, Block C, Rosen S, Brezis M, Heyman SN. Transient ureteral obstruction predisposes to ascending pyelonephritis and tubulo-interstitial disease: studies in rats. Urol Res 29:67-73, 2001 63. Reichman J, Shina A, Rosen S, Goldfarb M, Brezis M, Heyman SN. Renal effects of nabumetone: impairment of function in isolated perfused rat kidneys contrasts with preservation of renal function in vivo. Exp Nephrol 9:387-396, 2001 64. Eliakim R, Karmeli F, Cohen P, Heyman SN, Rachmilewitz D. Dual effect of nicotine administration: augmentation of jejunitis and amelioration of colitis induced by iodoacetamide in rats. Int J Colorectal Dis 16:14-21, 2001 65. Goldfarb M, Abassi Z, Rosen S, Shina A, Brezis M, Heyman SN. Chronic heart failure predisposes to hypoxic outer medullary tubular injury: studies in rats. Kidney Int 60:607-613, 2001 66. Rosen S, Heyman SN. Difficulties in understanding human "acute tubular necrosis": limited data and flawed animal models. Kidney Int 60:1220-4, 2001 67. Kassis I, Lak L, Adler J, Rinat C, Shazberg G, Fekede Tewade D, Shoshani E, Miller D, Heyman SN. Medical Relief Operation to Rural Northern Ethiopia: addressing an ongoing disaster. IMAJ 3:772-777, 2001. 68. Heyman SN, Shina A, Brezis M, Rosen S. Proximal tubular injury attenuates outer medullary hypoxic damage. Studies in the isolated perfused kidney. Exp Nephrol 10:259-266, 2002 69. Heyman SN, Specter G, Aamar S, Rubinger D, Pappo O, Ackerman Z. Systemic Lupus Erythematosus associated with Autoimmune Cholangiopathy. Liver 22:102-106, 2002 70. Heyman SN, Marmor S, Ben-Abraham R, Shani Y, Heled Y, Shapira B, Lifschitz-Mercer B, Amital H. Multi-Organ Failure in a Young Soldier, a clinical-pathological meeting. Harefuah 141:204-209, 2002 71. Heyman SN, Lieberthal W, Rogiers P, Bonventre JV, Animal Models of Acute Tubular Necrosis. Curr Op Crit Care 8:526-534, 2002 72. Heyman SN, Goldfarb M, Shina A, Karmeli F, Rosen S. N-acetylcysteine (NAC) ameliorates renal microcirculation: studies in rats. Kidney Int 63:634-641, 2003 73. Heyman SN, Rosen S. Dye induced nephropathy. Semin Nephrol 23:477-485, 74. Darmon D, Goldfarb M, Shina A, Rosen S, Heyman SN. The effect of poly- (ADP-ribose) polymerase (PARP) inhibition on outer medullary hypoxic damage. Nephron Physiol 95:1-9, 2003 75. Nassar T, Akkawi S, Shina A, Haj-Yehia A, Bdeir K, Tarshis M, Heyman SN, Higazi AAR. The in vitro and in vivo effect of tPA and PAI-1 on blood vessel tone. Blood 103:897-902, 2004 76. Heyman SN, Rosenberger C, Rosen S. Erythropoietin – a potential remedy for renal tubular injury? Kidney Int 65:737-738, 2004 77. Heyman SN, Shina A, Zohair H, Goldfarb M, Rosen S, Higazi AA. The Fibrinolytic System Attenuates Vascular Tone: Effects of Tissue Plasminogen Activator (tPA) and Aminocaproic Acid on Renal Microcirculation. Br J Pharmacol 141:971-978, 2004 78. Bellomo R, Ronco C, Kellum JA, Mehta RL, Palevsky P and the ADQI workgroup (including Heyman SN). Acute renal failure: definition, outcome measures, animal models, fluid therapy and information technology needs. The Second International Consensus Conference of the Acute Dialysis Quality Initiative(ADQI) Group. Critical Care 8:R204-R212, 2004 79. Korem M, Ackerman Z, Sciaki-Tamir Y, Gino G, Salameh-Giryes S, Perlberg S, Heyman SN. Post-partum acute kidney failure and hyponatremia - A clinical quiz. IMAJ 6:639-641, 2004 Francis BN, Abassi Z, Heyman SN, Winaver J, Hoffman A. Differential regulation of ETA and ETB in the renal tissue of rats with compensated and decompensated heart Failure. J Cardiovasc Pharmacol 44 (Suppl 1):S362-S365, 2004 81. Rosenberger C, Heyman SN, Rosen S, Shina A, Gruber G, Goldfarb M, Griethe W, Frei U, Bachmann S, and Eckardt KU. Upregulation of HIF in acute renal failure – evidence for a protective transcriptional response to hypoxia. Kidney Int 67:531-542, 2005 82. Heyman SN, Rosenberger C, Rosen S. Regional alterations in renal hemodynamics and oxygenation: a role in radiocontrast nephropathy. Nephrol Dial Transpl 20 (Suppl 1):i6-i11, 2005 83. Heyman SN, Goldfarb M, Rosenberger C, Shina A, Rosen S. The Effect of nicotine on the renal microcirculation in anesthetized rats: a potential for medullary hypoxic injury? Am J Nephrol 25:226-232, 2005 84. American Society of Nephrology Renal Research Report. J Am Soc Nephrol 16:1886-1903, 2005 (Heyman SN, participant) 85. Benbassat J, Baumal R, Heyman SN, Brezis M. Need for a paradigm shift in teaching basic clinical skills to medical students: the reflective clinical examination. Acad Med 80:1121-1126, 2005 86. Rosenberger C, Rosen S, Heyman S. Current understanding of HIF in renal disease. Kidney and Blood Pressure Research 28:325-340, 2005 87. Damianovich M, Ziv I, Heyman SN, Rosen S, Shina A, Kidron D, Aloya T, Grimberg H, Levin G, Reshef A, Bentolila A, Cohen A, Shirvan A. ApoSense: A Novel Technology for Imaging of Cell Death in Acute Renal Tubular Necrosis Eur J Nucl Med Mol Im 33:281-291, 2006 88. Maril N, Margalit R, Rosen S, Heyman SN, Degani H. Detection of Evolving Acute Tubular Necrosis with Renal 23Sodium MRI: Studies in Rats. Kidney Int 69:765-8, 2006 89. Goldfarb M, Rosenberger C, Abassi Z, Shina A, Zilbersat F, Eckhardt KU, Rosen S, Heyman SN. Acute-on-chronic renal failure in the rat: Functional compensation and hypoxia tolerance. Am J Nephrol 26:22-33, 2006 Rosenberger C, Shina A, Rosen S, Goldfarb M, Eckardt K, Heyman SN. Hypoxia inducible factors and tubular cell survival in isolated perfused kidneys. Kidney Int 70:60-70, 2006 91. Goldfarb M, Rosenberger C, Shina A, Rosen S, Heyman SN. A Role for Erythropoietin in the Attenuation of Contrast Medium-Induced Acute Renal Failure in Rats? Renal Failure 28:345-350, 2006 92. Elinav E, Rubinger D, Hiller N, Pizov G, Nadir E, Shapira Y, Heyman SN. Renal vein thrombosis and membranous glomerulopathy in a patient homozygote for factor V Leiden mutation: A mere coincidence? J Thromb Haemost 95:740-743, 2006 93. Rosenberger C, Rosen S, Heyman SN. Renal Parenchymal Oxygenation and Hypoxia Adaptation in Acute Kidney Injury. Clin Exp Pharmacol Physiol 33:980-988, 2006 94. Netz Y, Argov E, Burstin A, Brown R, Heyman SN, Dunsky A, Alexander N. Using a standing support device physical activity program to improve function in disabled wheelchair-bound nursing home residents: a pilot study. Disabil Rehabil Assist Technol 2:43-9, 2007 95. Heyman SN, Reches A, Safadi R, Cohen R. Introduction of a Brief Problem– Based–Learning (PBL) Experience in Traditional Medical School Curriculum. Harefuah 146: 435-8, 2007 Rosenberger C, Pratschke J, Rudolph B, Rosen S, Heyman SN, Babel N, Schindler R, Eckhardt KW, Frei U, Reinke P. Immunohistochemical Detection of Hypoxia-Inducible Factor-1alpha in Human Renal Allograft Biopsies. J Am Soc Nephrol 18:343-51, 2007 97. Nassar H, Lavi E, Akkawi S, Heyman SN, Raghunath PN, Tomaszewski J, Higazi AAR. α-defensin: Link between inflammation and atherosclerosis. Atherosclerosis 194: 452-7, 2007 98. Rosenberger C, Khamaisi M, Abassi Z, Weksler-Zengen S, Goldfarb M, Shilo V, Shina A, Zilbertrest F, Eckhardt KW, Rosen S, Heyman SN. Adaptation to hypoxia in the diabetic rat kidney. Kidney Int 73:34-42, 2008 99. Heyman SN, Rosen S, Rosenberger C. Renal parenchymal hypoxia, hypoxia adaptation and the pathogenesis of radiocontrast nephropathy. Clinical J Am Soc Nephrol 3:288-96, 2008 100. Rosenberger C, Goldfarb M, Shina A, Bachmann S, Frei U, Eckardt KU, Schrader T, Rosen S, Heyman SN. Evidence for Sustained Renal Hypoxia and Transient Hypoxia Adaptation in Experimental Rhabdomyolysis-Induced Acute Kidney Injury. Nephrol Dial Transpl 23:1135-43, 2008 101. Khamaisi M, Raz I, Shilo V, Shina A, Rosenberger C, Dahan R, Abassi Z, Meidan R, Lecht S, Heyman SN. Diabetes and radiocontrast media increase endothelin converting enzyme-1 in the kidney. Kidney Int 74:91-100, 2008 102. Rosenberg C, Goldfarb M, Khamaisi M, Shina A, Shilo V, Rosen S, Heyman SN. Acute kidney injury in the diabetic rat: studies in the isolated perfused and intact kidney. Am J Nephrol 28:831-9, 2008 103. Rosenberger C, Rosen S, Shina A, Frei U, Eckardt KU, Flippin LA, Arend M, Klaus SJ, Heyman SN. Activation of hypoxia inducible factors (HIF) ameliorates hypoxic distal tubular injury in the isolated perfused rat kidney. Nephrol Dial transplant 23: 3472–3478, 2008 104. Heyman SN, Khamaisi M, Rosen S, Rosenberger C. Renal parenchymal hypoxia, hypoxia response and the progression of chronic kidney disease. Am J Nephrol 28:998-1006, 2008 105. Khamaisi M, Dahan R, Hamed S, Abassi Z, Heyman SN, Raz I. Role of Protein Kinase C in the Expression of Endothelin Converting Enzyme-1 in Endothelial Cells. Endocrinology 150:1440-1449, 2009 106. Heyman SN, Rosen S, Rosenberger C. Animal models of renal dysfunction: acute kidney injury. Expert Opinion on Drug Discovery 4: 629-641, 2009 107. Khamaisi M, Heyman SN. The role of hypoxia and hypoxia adaptive response in the progression of chronic kidney disease. Harefuah, (in press) 108. Kahn A, Koslowsky B, Nir-Paz R, Temper V, Hiller N, Karlinsky A, Gur I, Hidalgo-Grass C, Heyman SN, Moses AE, Block C. Imported melioidosis in Israel: recognition and consequences. Emerg Infect Dis (in press) 109. Ben-Chetrit E, Peleg H, Aamer S, Heyman SN. The spectrum of MEFV associated diseases – Is it familial Mediterranean fever (FMF) only? Rheumatology (in press) 110. Heyman SN, Rosenberger C, Rosen S. Experimental ischemia-reperfusion - biases and myths: the proximal vs. distal hypoxic tubular injury debate revisited. Kidney Int (in press) 111. Karram T, Khamaisi M, Bishara B, Ramadan R, Nitecki S, Ben-Izhak O, Meretyk S, Winaver J, Heyman SN, Hoffman A, Abassi Z. Expression of endothelin receptors in human kidney: Possible source of urinary ETA and ETB. Kidney & Blood Pressure Research (in press) LETTERS AND CORRESPONDENCE
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Yagil Y, Heyman S. Makwa (non sterile skin cauterization) as a cause of tetanus. Lancet, 1 May; 1207, 1982. Heyman SN, Heyman A. Rare side effects of oral anticoagulants. Harefuah, 112;371, 1987. (Hebrew) Heyman SN, Greenfeld Z, Behar M, Mogle P, Brezis M. Spinal myoclonus induced by contrast material: An alternative explanation. AJNR 10:653, 1989. Heyman SN. Verapamil intoxication and hyperglycemia. J Emerg Med 7:407, 1989. Amitai Y, Heyman S. Additional causes of priapism. Ann Emerg Med 19:1357-8, 1990. Eilam O, Heyman SN. Wenckebach type atrioventricular block in severe alcohol intoxication. Ann Emerg Med 20:1170, 1991. Heyman SN. The usage of osmolar gap. Harefuah 125:126-127, 1993. (Hebrew) Heyman SN, Horovitz J, Nehama H, Sofer S, Orbach J, Amir Y, Adar A. Sudden death during fluid resuscitation: a lesson from Rwanda. Lancet 344:1509-1510, 1994. Shpilberg O, Pikarsky A, Heimann S, Epstein Y, Burstein R. Coma in mild hypothermia. Aviat Space Environ Med 65:878, 1994. Heyman SN, Brezis M. Asymptomatic group-B streptococcal pyelonephritis: an unusual cause of acute renal failure. Nephron 75:243-244, 1997. Rosen S, Bits H, Darmon D, Brezis M, Heyman S. Kitamura et al.: Inhibition of myo-inositol transport causes acute renal failure with selective medullary injury in the rat. Kidney Int 54:301-302, 1998. Heyman SN. Furosemide drip in diuretic-resistant congestive heart failure. Harefuah 139:163, 2000. (Hebrew) Heyman SN. Dopamine for acute renal failure: update. Harefuah 141:492-3, 2002 (Hebrew) Elinav E, Ackerman Z, Goterer A, Heyman SN. Acetazolamide-induced severe metabolic acidosis in a patient with diabetic type IV renal tubular acidosis. Ann Emerg Med 40:258-9, 2002 Gatt ME, Heyman SN. Treatment of tobacco use and dependence. N Engl J Med 347:294, 2002 Rosen S, Heyman SN. Concerns about KIM-1 as a Urinary Biomarker for ATN. Kidney Int 63:1955, 2003 Ackerman Z, Salemah S, Korem M, Heyman SN. Cyclic psychosis associated with the menstrual cycle. Possibly attacks of neuroporphyria. Harefuah 143:157, 2004 Heyman SN, Babayof I. Emphysematous complications in dentistry. IMAJ 7:278, 2005. Heyman, SN. New usage for an old drug: acetylcysteine for contrast-induced nephropathy. 145:239, 2006 (Hebrew) Rosenberger C, Rosen S, Heyman SN. Normotensive ischemic acute renal failure. N Engl J Med 357:2204-5, 2007 Heyman SN. Myocardial ischemic preconditioning. Harefuah 147:655-6 (Hebrew)

PROCEEDINGS, INTERNET PUBLICATIONS AND MISCELLANIOUS

1. Brezis M, Heyman SN, Greenfeld Z, Rosen S. Acute renal failure with thick ascending
limb necrosis from combined kidney insults in the rat. Proceedings of the Xth International Congress of Nephrology. Nephrology, Davison AM (ed), Baillere Tindall, London pp 945-954, 1988. 2. Heyman SN. Airborne field hospital in disaster area: Lessons from Armenia (1988) and Rwanda (1994). F.I.P., Military and Emergency Pharmacy Section. pp 1-8, Ittigen, Switzerland, 1997. 3. Heyman SN. Airborne Field Hospital in Disaster Settings: The Israeli Model. Aruchim (Readiness), Bulletin of the Israeli Ministry of Health, Emergency Division 5:9-11, 2000 (Hebrew). 4. Bonventre JV, Heyman SN, Lieberthal W, Rogiers P. Animal models of acute tubular necrosis, in: The ADQI II report, ADQI website , June 2003 5. Heyman SN. Regional alterations in renal hemodynamics and oxygenation: a role in radiocontrast nephropathy. In: Contrast Media Induced Nephropathy (CIN) Booklet by Schering, Bracco and Guebert, the European Renal Association / ETDA meeting, Lisbon, 2004 6. Heyman SN. Primary prevention of dye-induced nephropathy. In: ICU Nephrology, ARF and the Management of Poisoning. Postgraduate Education Course of the American Society of Nephrology. pp 103-119, Oct 2004 Heyman SN. Primary prevention of dye-induced nephropathy. Hypertension, Dialysis & Clinical nephrology. HDCN website 8. Block C, Cahn A, Koslowsky B, Nir-Paz R, Temper V, Karlinsky A, Gur I, Heyman SN, Mozes A. Melioidosis - Israel ex Thailand, CHAPTERS IN BOOKS
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Heyman SN, Weinstein JM, Rosen S, Brezis M. Current concepts on the pathophysiology of radiocontrast nephrotoxicity. Seminaires d' Uro-Nephrologie. Pitie-Salpetriere, Masson pub., Paris, pp 188-192, 1990. Heyman SN, Greenfeld Z, Brezis M. Succeptability of the kidney to hypoxia. in Update in Intensive Care and Emergency Medicine (14), Update 1991. JL Vincent (editor), Springer Verlag, Berlin, pp 435-443, 1991. Heyman SN, Rosen S, Brezis M. The renal medulla: Life at the edge of anoxia. In Circulation in Native and Artificial Kidneys. C Ronco, A Artigas, R Bellomo (Eds), S Karger AG, Basel, pp 16-26, 1997. Heyman SN, Brezis M, Rosen S. The isolated perfused rat kidney model in experimental renal injury. In "Clinical Nephrotoxins: Renal Injury from Drugs and Chemicals", Bennett WM, DeBroe ME, Porter GA, Verpooten GA (Eds), Kluwer Academic Publishers, Dordrecht, pp 77-82, 1998. Heyman SN. Furosemide and oxygen sparing. In “Critical Care Focus (1) Renal Failure”, Galley HF (Ed), Intensive Care Society, BMJ Books, London, pp 45-59, 1999. Heyman SN, Brezis M. The Kidney. In “Pulmonary and peripheral gas exchange in health and disease”, Roca J, Rodriguez-Roisin R, Wagner P (Eds), Lung Biology in Health and Disease Vol 148, Marcel Dekker Inc., New York, pp 447-467, 2000. Heyman SN, Brezis M, Cronin RE. Radiocontrast Media-Induced Acute Renal Failure. In "Diseases of the Kidney and Urinary Tract", Schrier R (Ed.), 8th edition, Lippincott, Williams and Wilkins pp 1099-1120, 2006 Heyman SN. Iron Poisoning. In "Israeli Encyclopedia of Medicine", Y shoenfeld (Ed.) Israeli Medical Association and Yediot Pub, pp 1852-3, 2007 Rosenberger C, Rosen S, Paliege A, Heyman SN. Pimonidazole Adduct Immunohistochemistry in the Rat Kidney: Detection of Tissue Hypoxia. In Methods of Molecular Biology Vol 466: Kidney Research. Hewitson TD, Becker GJ (Ed), Springer / Humama Press, Totowa, NJ, pp161-174, 2009 Heyman SN, Rosen S, Rosenberger C. Critical assessment of experimental models of acute renal failure. In "Critical Care Nephrology", Ronco C, Bellomo R & Kellum J (Eds), 2nd Ed, Saunders/Elsevier, pp 237-250, 2009
ABSTRACTS
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Heyman SN, Reubinoff CA, Brezis M, Epstein FH, Rosen S. Acute renal failure (ARF) from radiocontrast; Selective injury to medullary thick ascending limbs (mTALs). A possible pathogenic mechanism. American Federation for Clinical Recearch. Annual Meeting Washington DC, May, 1986. Rosen S, Brezis M, Heyman SN, Greenfeld Z, Epstein FH. Acute renal failure with selective medullary injury from combined insults in rats; Role of medullary hypoxia. Clin Res 35;637A, 1987. Brezis M, Heyman SN, Greenfeld Z, Epstein FH, Rosen S. Selective hypoxic injury to medullary thick assending limb in vivo. International Congress of Nephrology, London, 1987. Rosen S, Heyman SN, Reubinoff CA, Greenfeld Z, Lechene C, Epstein FH, Brezis M. Radiocontrast Nephropathy. United States and Canadian Academy of Pathology, Annual Meeting, 1988. Heyman SN, Brezis M, Greenfeld Z, Rosen S. Protective role of furosemide and saline in radiocontrast induced acute renal failure. Clin Res 36:520A, 1988. Brezis M, Heyman SN, Spokes K, Epstein FH, Rosen S. Role of nitric oxide in medullary oxygen balance. J Am Soc Nephrol 1:438, 1990. Epstein FH, Heyman SN, Spokes K, Rosen S. Mechanism of glycine protection in hypoxic injury: Analogies with glycine receptor. J Am Soc Nephrol 1:595, 1990. Clark BA, Heyman SN, Spokes K, West C, Epstein FH. Rise in plasma endothelin produced by radiocontrast agents. J Am Soc Nephrol 1:412, 1990. Heyman SN, Spokes K, Epstein FH, Brezis M, Silva P, Rosen S. Early functional and morphological changes in radiocontrast nephropathy. J Am Soc Nephrol 1:596, 1990. Stillman IE, Brezis M, Greenfeld Z, Heyman SN, Rosen S. The effect of cyclosporine A on the medullary thick ascending limb. J Am Soc Nephrol 1:620, 1990. Stillman IE, Brezis M, Greenfeld Z, Heyman SN, Rosen S. Cyclosporine (CsA) toxicity: morphometric analysis of the medullary thick ascending limb (mTAL). United States and Canadian Academy of Pathology, Annual meeting, 1991. Heyman SN, Brezis M, Epstein FH, Spokes K, Stillman I, Rosen S. Chronic amphotericin nephropathy: selective inner stripe and medullary ray injury. Clin Res 39:248A, 1991. Heyman SN, Clark BA, Kaiser N, Rosen S, Brezis M, Spokes K, Epstein FH. Radiocontrast agents induce endothelin release from cultured endothelial cells. Clin Res 32:309A, 1991. Brezis M, Heyman SN, Fuhro R, Epstein FH. Determinants of intrarenal oxygenation gradients. Clin Res 32:389A, 1991. Heyman SN, Brezis M, Epstein FH, Spokes K, Rosen S. Glycine increases medullary thick ascending limb (mTAL) damage from radiocontrast and hypoxic insults in rats. A role for medullary oxygen insufficiency ? J Am Soc Nephrol 2:647, 1991. Heyman SN, Clark BA, Cantley L, Brezis M, Rosen S, Kaiser N, Spokes K, Epstein FH. Low toxicity of the radiocontrast agent ioversol: relationship to reduced stimulation of endothelin release? J Am Soc Nephrol 2:664, 1991. Brezis M, Heyman SN, Fuhro R, Epstein FH, Rosen S. Intrarenal vasoconstriction in myoglobin nephrotoxicity. J Am Soc Nephrol 2:644, 1991. Cantley LG, Heyman SN, Epstein FH. Radiocontrast agents induce endothelin-1 mRNA in bovine endothelial cells. J Am Soc Nephrol 2:660, 1991. Rosen S, Brezis M, Epstein FH, Spokes K, Heyman SN. Medullary thick ascending limb (mTAL) injury in the ischemia-reflow model. J Am Soc Nephrol 2:654, 1991. Rosen S, Heyman SN, Epstein FH, Spokes K, Stillman I, Brezis M. Regional vulnerability of the kidney to hypoxia. In "Newer Aspects of Renal Cell Injury, A Forefronts in Nephrology Symposium (Int Soc Nephrol), 1991. Stillman LE, Heyman SN, Brezis M, Epstein FH, Spokes K, Rosen S. Adaptation of the renal medulla to salt deficiency: Alterations in mTAL size and medullary pO2. J Am Soc Nephrol 3:820, 1992. Stillman LE, Brezis M, Heyman SN, Epstein FH, Spokes K, Rosen S. Effects of salt depletion on the kidney: changes in medullary oxygenation and medullary thick ascending limb size. XIIth International Congress of Nephrology, Jerusalem, 554, 1993. Heyman SN, Kamimski N, Brezis M. Effects of dopamine (D) on renal microcirculation and oxygenation. J Am Soc Nephrol 5:604, 1994. Heyman SN, Karmeli F, Rachmilewitz D, Brezis M. Ketotifen induces nitric oxide synthase (NOS) and renal vasodilation. J Am Soc Nephrol 5:580, 1994. Heyman SN, Fuchs S, Yafe R, Beeri R, Shina A, Brezis M, Rosen S. Impaired renal medullary microcirculation and tissue damage during acute ureteral obstruction: clinical implications? J Am Soc Nephrol 6:980, 1995. Fuchs S, Jaffe R, Beeri R, Heyman SN, Shina A, Rosen S, Brezis M. Failure of insulin-like growth factor 1 (IGF-1) to improve radiocontrast nephropathy. J Am Soc Nephrol 6:997, 1995. Heyman SN, Brezis M. Pathophysiology of radiocontrast nephropathy. J Radiologie 76:727, 1995. Heyman SN, Greenbaum R, Shina A, Rosen S, Brezis M. Myoglobinuric acute renal failure in the rat: a role for acidosis? Annual meeting of the Israeli Association for Emergency Medicine, 1996. Heyman SN, Fuchs S, Jafe R, Beeri R, Rosen S, Brezis M. Deleterious effects of indomethacin, forced hydration and radiocontrast on renal microcirculation and morphology during acute ureteral obstruction in the rat:implications for the treatment of renal colic? Annual meeting of the Israeli Association for Emergency Medicine, 1996. Babayof I, Heyman SN. Emphysematous complications in dentistry, 1960-1993. Annual meeting of the Israeli Association for Emergency Medicine, 1996. Heyman SN. Airborne field hospital in disaster area: Lessons from Armenia (1988) and Rwanda (1994). Pharmacy Word Congress, Jerusalem, 1996. Heyman SN, Brezis M. The outer medulla: Life at the edge of anoxia. Third Annual Symposium on Applied Physiology of the Peripheral Circulation, Barcelona, 1996. Heyman SN, Haj Ichia A, Rachmilewitz D, Brezis M. Intrarenal nitric oxide monitoring with a clark-type electrode: potential pitfalls. J Am Soc Nephrol 9:1563, 1996. Heyman SN, Rosen S, Brezis M. Effects of endotoxin upon intrarenal microcirculation. J Am Soc Neprol 9:1862, 1996. Heyman SN, Darmon D, Goldfarb M, Bits H, Shina A, Brezis M, Rosen S. Endotoxin (E) induces medullary hypoxic damage: studies in-vivo and in isolated perfused kidneys. J Am Soc Nephrol 8:602A, 1997. Heyman SN, Karmeli F, Shina A, Rachmilewitz D, Brezis M. The effect of contrast media (CM) on intrarenal nitric oxide synthase activity. J Am Soc Nephrol 8:330A, 1997. Bitz H, Darmon D, Goldfarb M, Shina A, Rosen S, Block C, Heyman S, Brezis M. Vulnerability to pyelonephritis after relief of ureteral obstruction. J Am Soc Nephrol 8:611A, 1997. Heyman SN, Ginosar Y, Niel L, Jacob Amir, MD, Marx N, Shapiro M, Maayan S. Meningococcal meningitis among Rwandan refugees: diagnosis, management and outcome in a field hospital. Annual meeting of the Israeli Association for Emergency Medicine, 1998. Heyman SN, Ginosar Y, Shapiro M, Kluger Y, Marx N, Maayan S. Diarrheal epidemics among Rwandan refugees, 1994: management and outcome in a field hospital. Annual meeting of the Israeli Association for Emergency Medicine, 1998. Heyman SN, Darmon D, Bitz H, Brezis M, Shina A, Rosen S. Selective cyclooxygenase (COX)-2 inhibition adversely affects function and morphology in the isolated perfused rat kidney. J Am Soc Nephrol, 9:595A, 1998. Heyman SN, Godfarb M, Darmon D, Brezis M. The role of nitric oxide (NO) and endothelin (ET) in renal microcirculatory response to endotoxin. J Am Soc Nephrol, 9:338A-339A, 1998. Reichman J, Cohen S, Shina A, Brezis M, Rosen S, Heyman SN. Renal safty of nabumetone, a predominantly selective cyclooxygenase (COX)-2 inhibitor. Acute and chronic studies in rats. J Am Soc Nephrol 10:651A, 1999. Goldfarb M, Abassi Z, Darmon D, Shina A, Brezis M, Rosen S, Heyman SN. Chronic heart failure predisposes to hypoxic outer medullary tubular injury: studies in rats. J Am Soc Nephrol 10:631A, 1999. Yanko R, Raz I, Brezis M, Heyman SN. Hyperglycemia directly induces renal vasodilation in anesthetized rats: a role for nitric oxide? J Am Soc Nephrol 10:391A, 1999. Reichman J, Shina A, Rosen S, Brezis M, Heyman SN. Nabumetone, a selective cyclooxygenase (COX)-2 inhibitor, is free of renal adverse effects. Studies in anesthetized rats. 50th jubillee of the Medical School, the Hebrew University and the Hadassah Medical Organization, 825, 1999. Reichman J, Shina A, Darmon D, Brezis M, Rosen S, Heyman SN. Selective cyclooxygenase (COX)-2 inhibition adversely affects function and morphology in the isolated perfused rat kidney. 50th jubillee of the Medical School, the Hebrew University and the Hadassah Medical Organization, 824, 1999. Heyman SN, Godfarb M, Darmon D, Brezis M. The role of nitric oxide (NO) and endothelin (ET) in renal microcirculatory response to endotoxin. 50th jubillee of the Medical School, the Hebrew University and the Hadassah Medical Organization, 481, 1999. 48. Heyman SN, Goldfarb M, Darmon D, Brezis M. Tissue oxygenation modifies nitric oxide bioavailability. 50th jubillee of the Medical School, the Hebrew University and the Hadassah Medical Organization, 416, 1999. 49. Ofran Y, Stalnikowitz R, Heyman SN. Peripheral vasospasm secondary to the combined effects of cocaine, ergotamine and beta-blockers. 11th Scientific meeting of the Israeli Society of Toxicology, March, 2000. 50. Heyman SN, Shina A, Spokes K, Brezis M, Rosen S. Proximal tubular injury attenuates outer medullary hypoxic damage. Studies in the isolated perfused kidney. J Am Soc Nephrol 11:601A, 2000. 51. Heyman SN, Shina A, Goldfarb M, Rosen S. N-acetylcysteine (NAC) ameliorates renal microcirculation. J am Soc Nephrol 12:781A-782A, 2001 52. Goldfarb M, Rosen S, Shina A, Heyman SN. The effect of poly-(ADP-Ribose) polymerase (PARP) inhibition with 3-Aminobenzamide (3-AB) on outer medullary hypoxic damage. J am Soc Nephrol 12:780A, 2001 53. Heyman SN, Shina A, Zohair H, Goldfarb M, Rosen S, Higazi AAR. The Fibrinolytic System and Renal Hemodynamics: Studies in Rats J Am Soc Nephrol 13:336A, 2002 54. Heyman SN, Shina A, Goldfarb M, Rosen S. The Effect of Nicotine on the Renal Microcirculation in Anesthetized Rats: a potential for medullary hypoxic injury. J Am Soc Nephrol 13:333A, 2002 55. Goldfarb M, Rosen S, Shina A, Heyman SN. Acute renal failure superimposed on pre- existing tubulointerstial disease in rats: contribution of both chronic and acute tubular damage to renal dysfunction. J Am Soc Nephrol 13:547A, 2002 56. Rosenberger C, Heyman SN, Rosen S, Frei U, Bachmann S, Eckardt KU. Expression of hypoxia-inducible-factors-1alpha and 2alpha in acute renal failure. J Am Soc Nephrol 13:136A-137A, 2002 57. Abassi Z, Francis BN, Heyman SN, Winaver J, Hoffman A. Differential regulation of ETA and ETB in the renal tissue of rats with compensated and decompensated heart failure Eighth International Conference on Endothelin, Tsukura, Japan 2003 58. Rosen S, Rosenberger C, Heyman SN. The Human Renal Biopsy in ATN Versus Animal Models of ATN: Conflicts and agreements. ARF satellite symposium, International Society of Nephrology Meeting, Berlin 2003. 59. Heyman SN. Renal medullary hypoxia: physiology and pathophysiology. The annual meeting of the Israel Society for physiology and pharmacology, A2, Maale hahamisha, Israel, 2003 60. Argov E, Netz Y, Brown R, Burstin A, Heyman S N. Exercise as a modifier of physical frailty and well-being in functionally impaired nursing home residents - the use of a standing device. 8th congress of the European Federation for Research in Rehabilitation, Lublijana, Slovenia, 2004 61. Cohen R, Safadi R, Heyman SN. A brief problem-based learning experience for students prior to entering the clinical clerkship phase of training. Faculty Development and Professionalism in Medical Education meeting, Tel Aviv, 2004. 62. Heyman SN, Rosenberger C, Shina A, Goldfarb M, Eckardt KU, Rosen S. Cell-specific expression of hypoxia-inducible transcription factors (HIF) in the isolated perfused kidney. J Am Soc Nephrol 15:254A, 2004 63. Heyman SN, Abassi Z, Khamaisi M, Shina A, Goldfarb M, Rosen S. Rosenberger C. Diabetes predisposes to medullary hypoxia with activation of hypoxia inducible factors (HIF) and upregulation of endothelin-B receptors (ETB). J Am Soc Nephrol 15:468A, 2004 64. Damianovich M, Heyman SN, Rosen S, Shina A, Reshef A, Kevin G, Grimberg H, Aloya R, Cohen A, Ziv I, Shirvan A. Apoptosis-sensor: a novel technology for functional molecular imaging of cell death in models of acute renal tubular necrosis. J Am Soc Nephrol 15:718A, 2004 65. Maril N, Heyman SN, Rosen S, Degani H. 23Na MRI Study of the Renal Sodium Distribution at an Early Phase of ARF in the Intact Rat Kidney. J Am Soc Nephrol 15:461-2A, 1004 66. Shirvan A, Damianovich MD, Heyman SN, Rosen S, Shina A, Reshef A, Kevin G, Grimberg H, Aloya R, Cohen A, Ziv I. Functional molecular imaging of cell death in models of acute renal tubular necrosis. The Society of Molecular Imaging (SMI) conference, St. Lewis, 2004 67. Goldfarb M, Shina A, Rosen S, Heyman SN. Erythropoietin Attenuates Radiocontrast- Induced Acute Renal Failure in Rats. Israeli Society of Nephrology meeting, Eilat, March 2005 68. Heyman SN. The The Effect of nicotine on the renal microcirculation in anesthetized rats: a potential for medullary hypoxic injury. Israeli Society of Toxicology meeting, Ramat gan, May 2005 69. Heyman SN, Rosenberger C, Shina A, Shilo V, Eckardt KU, Rosen S. Renal Medullary Hypoxic Damage in the Diabetic Rat: Studies in Vivo and in Isolated Perfused Kidneys. J Am Soc Nephrol 16:402A, 2005 70. Goldfarb M, Shina A, Rosenberger C, Rosen S, Heyman SN. Attenuation of Radiocontrast-Induced Nephropathy (CIN) in the Rat By Erythropoietin (EPO). J Am Soc Nephrol 16:621A, 2005 71. Rosenberger C, Goldfarb M, Abassi Z, Shina A, Eckardt KU, Rosen S, Heyman SN. Acute-On-Chronic Renal Failure (RF) in the Rat: Functional Compensation and Hypoxia. J Am Soc Nephrol 16:621A, 2005 72. Heyman SN. Hypoxia and Hypoxia adaptation in the diabetic rat kidney. D-CURE Annual Meeting, Weitzman's Institute, Rehovot, Israel, 2006. 73. Heyman SN. Hypoxia and Hypoxia adaptation in the diabetic rat kidney. D-CURE Annual Meeting, Weitzman's Institute, Rehovot, Israel, 2006. 74. Rosenberger C, Shina A, Goldfarb M, Rosen S, Heyman SN. Heyman SN. Sustained Hypoxia and Hypoxia Adaptation in Rhabdomyolysis-Induced Acute Kidney Injury. World Congress of Nephrology, Rio De Janeiro, April 2007 75. Khamaisi M, Raz I, Rosenberger C, Meidan R, Abassi Z, , Shilo V, Heyman SN. The effect of diabetes and radiocontrast media on renal expression of endothelin converting enzyme-1. (Submitted), Endothelin Conference, Beragmo, Italy 2007 76. Khamaisi M, Shilo V, Rosenberger C, Goldfarb M, Shina A, Meidan R, Raz I, Heyman SN. Diabetes and radiocontrast medium induce converting enzyme (ECE)-1 in vitro and in the renal medulla: a plausible novel mechanism for elevated endothelin. J Am Soc Nephrol 18:166A, 2007 77. Heyman SN, Shina A, FillPin LA, Arend M, Klaus SJ, Eckardt KU, Rosen S, Rosenberger C. Activation of hypoxia inducible factors (HIF) ameliorates hypoxic distal tubular injury in the isolated perfused rat kidney. J Am Soc Nephrol 18:645A, 2007 78. Paliege A, Rosenberger C, Heyman SN, Klaus SJ, Moreira L, Bachmann S. Stimulation of autochthonous renal erythropoietin expression by prolyl hydroxylase inhibition. Anatomische Gesellschaft 103rd meeting, Innsbruck, Austria, March 2008 79. Karram T, Bishara B, Ramadan R, Abu-Saleh N, Heyman S, Winaver J, Hoffman A, Abassi Z. Expression of endothelin ETA and ETB receptors in human kidney: Possible source of urinary ETA and ETB . JASN, 19:609A, 2008 80. Khamaisi M, Axelrod J, Rosenberger C, Heyman SN. Endothelin converting enzyme (ECE)-1: a plausible target gene for hypoxia inducible factor (HIF). Endothelin Conference, Montréal, 2009 (submitted) 81. Nechemia-Arbeli Y, Rosenberger C, Khamaisi M, Koesters R, Shina A, Klaus S, Shriki A, Rosen S, Axelrod JH, Heyman SN. Renal hypoxia inducible factors (HIF) and STAT3 cross talk in vivo. ASN 2009 (submitted) 82. Paliege A, Rosenberger C, Bondke A, Sciesielski L, Heyman S, Flippin L, Arend M, Klaus S, Bachmann S. STIMULATION OF RENAL ERYTHROPOIETIN EXPRESSION BY HIF PROLYL HYDROXYLASE INHIBITION IS CONFINED TO HIF-2ALPHA-EXPRESSING FIBROBLASTS. Erythropoietin conference, Luebeck, Germany, 2009 MANUSCRIPTS SUBMITTED/ IN PREPARATION

Rosenberger C, Heyman SN, Rosen S. Sublethal renal parenchymal injury and the impact of preconditioning: bad and good news Paliege A, Rosenberger C, Heyman SN, Arend M, Klaus SJ, Bachmann S. Stimulation of autochthonous renal erythropoietin expression by HIF-prolyl hydroxylase inhibition Abu Fanne R, Nassar T, Mazuz A, Waked A, Akkawi S, Hijazi N, Heyman SN, Goelman G, Higazi AAR. Neuroprotection by glucagon and insulin: Role of gluconeogenesis Heyman SN, Rosen S, Rosenberger C. Contrast medium-induced nephropathy. In: Oxidative Stress in Basic Research and Clinical Practice: Renal Disorders (Section 1-17), Miyata T, Eckardt KW, Nangaku M (Eds), Humana Press/Springer Science (invited book chapter) Acute Tubular Necrosis. In: Experimental Models For Renal Diseases: Impact On Understanding Pathogenesis And Improving Diagnosis. Guillermo Herrera, (ed) (invited book chapter)

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