Microsoft word - jar_curriculum vitae.doc

CURRICULUM VITAE


NAME: Joaquim Alexandre Ribeiro
DATE OF BIRTH: 9th August, 1941, Vila Fernando –Guarda, Portugal

NATIONALITY: Portuguese
ID: nº 1582055, of Lisboa, 5-5-2004
AREA OF INVESTIGATION:
Neuropharmacology. Neuromodulation by adenosine at the peripheral (neuromuscular
junction) and central (hippocampus and cerebral cortex) nervous systems. Purinergic
regulation of neurotransmitter release. Adenosine regulation of carotid body
chemoreceptor activity. Characterization of adenosine receptors. Extracellular
adenosine formation and inactivation. Role of adenosine in neuronal plasticity.
Interactions between adenosine A1- and A2-receptors, and receptors for other
neurotransmitters and neuromodulators.
Cardovascular Pharmacology. Adenosine and cardiac dysrhythmias.
DEGREES
M.D. (University of Lisbon)
Ph.D. (University of Edinburgh)
'Agregação' (University of Porto)

POSITIONS
2010 – Coordinator (Vice-Rector) of the Health Sciences Strategic Area of the
2009 – Vice-President of the Institute of Molecular Medicine 2004 – Vice-Dean of the Faculty of Medicine, University of Lisbon. 2004 – PI at the Unit of Neurosciences, Institute of Molecular Medicine 2002 - Director of the Institute of Phamacology and Neurosciences, Faculty of 1997 - Full Professor at the Faculty of Medicine, University of Lisbon 1997/00 – Director of Laboratory of Neurosciences, Faculty of Medicine, University of 1988/00 - Professor (catedrático) (invited) at the Institute for Biomedical Sciences Abel 1985/87 - President of the Studies Committee of the Gulbenkian Institute of Science. 1983/85 - President of the Scientific Council of the Gulbenkian Institute of Science. 1982/97 - Head of the Laboratory of Pharmacology of the Gulbenkian Institute of
RESEARCH CAREER
1988/97 - Senior Investigator at the Gulbenkian Institute of Science.
1982/88 - Investigator at the Gulbenkian Institute of Science.
1979/82 - Visiting Scientist at the Department of Pharmacology, Faculty of Medicine,
1974/82 - Assistant Investigator at the Gulbenkian Institute of Science. 1972/73 - Post-doctoral at the Department of Pharmacology, Faculty of Medicine, 1970/72 - Assistant at the Gulbenkian Institute of Science.

INTERNATIONAL COMMITTEES
2007 – Member of the Standing Committee of European Medical Research Council,
European Science Foundation
2006/10 - Member of the Managing Committee of the COST Action B30 –NEREPLAS
on Neuronal Plasticity
1997/05 - Member of the Managing Committee of the COST Action B10 on Brain
Repair, coordinator of the Neuroprotection group

INVOLVEMENT IN POST-GRADUATE TRAINING
1997-2007: Coordinator of the Mastercourse/PhD in Neurosciences at FMUL
Supervisor of Ph.D. students
Supervisor of M.Sc. students
Supervisor of Pre-graduate students (Thesis)
Post-doctoral supervision

EDITORIAL BOARDS (member)
Autonomic Neuroscience
European Journal of Pharmacology (1994-2004)
Basic &Clinical Pharmacology & Toxicology
Purinergic Signalling
Anales de la Real Academia de Farmacia
Journal of Caffeine Research

PUBLICATIONS

Papers in refereed Journals:

192. Aroeira, R, Ribeiro, J A., Sebastiao, A M and Valente C (2011). Expression pattern
of glycine receptor at the rat hippocampus: changes from the embryo to the adult.
, J Neurochem, accepted
191. Lopes, L.V., Sebastião, A.M. and Ribeiro, J.A. (2011). Adenosine and related drugs in brain diseases: present and future in clinical trials Curr Topics Med
Chem (in press-18-5-2010)
190. Sebastião, A.M., Assaife-Lopes, N., Diógenes, M.J., Vaz, S., and Ribeiro, J.A., (2010) Modulation of brain-derived neurotrophic factor (BDNF) actions in the nervous system by adenosine A2A receptors and the role of lipid rafts (BBA
Biomembranes on line pub med july)
189. Sousa V C., Assaife-Lopes, N., Brett, R. R., Ribeiro J. A., Pratt, J A, Sebastião A. M. (2011). Regulation of hippocampal cannabinoid CB1 receptor actions by
adenosine A1 receptors and chronic caffeine administration: implications for the
effects of …5 tetrahydrocaqnnabinol on spatial memory. (under review
Neuropsychopharmacology on line october)
188. Dias R Ribeiro J A and Sebastiao A M (2011). Enhancement of AMPA currents and GluR1 membrane expression through PKA-coupled adenosine A2A receptors
(under review Hippocampus, in press on line).
187. Ribeiro J.A. (2010). Neuroética, a emergência de uma nova disciplina em neurociências. Sinapse, 40, 32-33.
186. Ribeiro, J. A. and Sebastião A. M. (2010). Modulation and MetaModulation of Synapses by Adenosine. Acta Physiol 199, 161-169.
185. Ribeiro J A and Sebastiao A M (2010). Caffeine and Adenosine. J Alzheim dis.,
20, 3-15.
184. Assaife-Lopes, N., Sousa V. C., Pereira D. B, Ribeiro J. A., Chao M. V. and Sebastião A. M. (2010). Activation of adenosine A2A receptors induces TrkB
translocation and increases BDNF-mediated phospho-TrkB localization in lipid
rafts: implications for neuromodulation. J Neurosci., 30: 8468–8480.
183. Pedata, F , Pugliese, A M, Sebastião A M and Ribeiro J A. (2010). Adenosine A3
receptor signaling in the central nervous system. A3 Adenosine Receptors from
Cell Biology to Pharmacology and Therapeutics, P.A. Borea (ed) , DOI
10.1007/1978-90-481-3144-0_1, Springer Science+Business Media B.V.
182. Pousinha, P.A., Sebastião, A.M and Ribeiro, J.A. (2010). Predominance of
adenosine excitatory over inhibitory effects on transmission at the neuromuscular
junction of infant rats J Pharmacol Exp Ther. 2010, 332:153-163.
181. Serpa, A., Ribeiro, J A and Sebastião, A M (2009). Cannabinoid CB1 and Adenosine A1 receptors independently inhibit hippocampal synaptic transmission
Eur J Pharmacol 623, 41-46.
180. Sebastião AM and Ribeiro JA (2009). Tuning and Fine-tuning synapses with
adenosine, Current Neuropharmacol, 7, 180-194.
179. Sebastião AM and Ribeiro J A (2009). Adenosine Receptors and the Central
Nervous System, Handbook Exp Pharmacol, 193: 471-534.
178. Sebastião, A.M and Ribeiro, J.A. (2009). Triggering neurotrophic factor actions
through adenosine A2A receptor activation: implications for neuroprotection Br J
Pharmacol, 158: 15-22.
177. Fontinha, B, Delgado-García, J M, Madroñal, N. Ribeiro, J. A., Sebastiao, A. M.
and Gruart A. (2009). Adenosine A2A receptor modulation of hippocampal CA3-
CA1 synapse plasticity during associative learning in behaving mice"
Neuropsychopharmacology, 34:1865-1874
176. Cristovão-Ferreira, S., Vaz, S., Ribeiro, J.A. and Sebastião, A.M. (2009).
Adenosine A2A receptors, through PKA activation, restrain PKC inhibition of
GAT-1-mediated GABA uptake by nerve terminals. J Neurochem., 109, 336-
347.
175. Gomes CA, Simões PF, Canas PM, Quiroz C, Sebastião AM, Ferré S, Cunha RA, Ribeiro JA. (2009). GDNF control of the glutamatergic cortico-striatal pathway
requires tonic activation of adenosine a2a receptors. J Neurochem., 108, 1208-
174. Serpa A., Ribeiro, J.A. e Sebastião, A.M. (2009). Adenosine A1 and cannabinoid
CB1 receptors independently inhibit hippocampal synaptic transmission. Rev Fac
Med Lisboa, 14, 59-64.
173. Ribeiro, JA (2008). Fine tuning neuromodulation by adenosine and
neuroprotection. An R. Acad. Nac. Farm., 74, 387-408.
172. Fernandes, C., Pinto-Duarte, A. Ribeiro, J.A. And Sebastião, A.M. (2008)
Postsynaptic action of brain-derived neurotrophic factor attenuates alpha7
nicotinic acetylcholine receptor-mediated responses in hippocampal interneurons.
J Neurosci.,28, 5611-5618.
171. Vaz S. Ferreira, A:S., Ribeiro, J.A. And Sebastião, A.M. (2008). Brain-derived
neurotrophic factor inhibits GABA uptake by the rat hippocampal nerve terminals
Brain Res., 1219:19-25
170. Fontinha B.M., Ribeiro, J.A. & Sebastião, A.M. (2008). Enhancement of long –
term potentiation by BDNF requires adenosine A2A receptor activation by
endogenous adenosine Neuropharmacology, 54, 924-933.
169. Cunha-Reis, D., Ribeiro, J.A. & Sebastião, A.M. (2008). A(1) and A(2A)
receptor activation by endogenous adenosine is required for VIP enhancement of
K(+)-evoked [(3)H]-GABA release from rat hippocampal nerve terminals.
Neurosci Letts 430, 207-212.
168. BIBER K, PINTO-DUARTE, A., WITTENDORP, MC, DOLGA, AM, FERNANDES, CC, KUNZEL JVFD, KEIJSER, JN, DEVRIES, R, IJZERMAN,
AP, RIBEIRO, JA, EISEL, U, SEBASTIÃO AM and BODDEKE, GM. (2008).
Interleukin-6 upregulates neuronal adenosine A1 receptors: implications for
neuromodulation and neuroprotection. Neuropsychopharmacology 33, 2237–
2250.
167. DIÓGENES, M.J., ASSAIFE-LOPES N. PINTO-DUARTE A, RIBEIRO,
J.A.,& SEBASTIÃO, A.M. (2007). Influence of age on BDNF modulation of
hippocampal synaptic transmission: interplay with adenosine A2A receptors.
Hippocampus, 2007;17:577-585.
166. CUNHA-REIS, D., FONTINHA, B., RIBEIRO, J.A. & SEBASTIÃO, A.M.
(2007). Tonic adenosine A1 and A2A receptor activation is required for the
excitatory action of VIP on synaptic transmission in the CA1 area of the
hippocampus. Neuropharmacology 52, 313-320.
165. QUIROZ, C., GOMES, C, PAK A.C., RIBEIRO J.A., GOLDBERG, S.R.,
HOPE, B.T. and FERRÉ, S. (2006). Blockade of adenosine A2A receptors
prevents protein phosphorylation in the striatum induced by cortical stimulation.
J. Neurosci., 18, 10808-10812.
164. GOMES, C.A.R.V., VAZ, S.H., RIBEIRO J.A. & SEBASTIÃO, A.M (2006).
Glial cell line-derived neurotrophic factor enhances dopamine release from striatal
nerve endings in an adenosine A2A receptor dependent manner. Brain Res.,
1113, 129-136.
163. CUNHA-REIS, D., RIBEIRO, J.A. & SEBASTIÃO, A.M. (2006). VPAC2
receptor activation mediates VIP enhancement of population spikes in the CA1
area of the hippocampus. Ann NY Acad Sci., 1070, 210-214.
162. FRAGATA, I., RIBEIRO, J.A. & SEBASTIÃO, A M. (2006). Nitric oxide
mediates interactions between GABA-A receptors and adenosine A1 receptors in
the rat hippocampus. Eur J Pharmacol., 543, 32-39.
161. POUSINHA, P.A., DIÓGENES, M.J.,. RIBEIRO, J.A. & SEBASTIÃO, A.M
(2006). Triggering of BDNF facilitatory action on neuromuscular transmission by
adenosine A2A receptors. Neurosci Letts, 404, 143-147.
160. COELHO J.E., REBOLA, N., FRAGATA, I., RIBEIRO, J.A. de MENDONÇA,
A. and CUNHA, R. A. (2006). Hypoxia-induced desensitization and
internalization of adenosine A1 receptors in the rat hippocampus. Neuroscience,
138, 1195-1203.
159. CUNHA-REIS, D., SEBASTIÃO, A.M. & RIBEIRO, J.A. (2005) VIP enhances
synaptic transmission to hippocampal CA1 pyramidal cells through activation of
both VPAC1 and VPAC2 receptors. Brain Res., 1049, 52-60.
158. SILVA, B.M., de MENDONÇA, A. & RIBEIRO, J.A. (2005). Long-term
depression is not modulated by ATP receptors in the rat CA1 hippocampal region.
Neurosci. Letts, 383, 345-349.
157. RIBEIRO, J.A. (2005). What adenosine neuromodulation can do for
neuroprotection. Curr.Drug Targets: CNS & Neurol. Disorders, 4, 327-331.
156. PINTO-DUARTE, A. COELHO, J.E:, CUNHA, R.A. RIBEIRO, J.A. &
SEBASTIÃO, A.M. (2005). Adenosine A2A receptors control the extracellular
levels of adenosine through modulation of nucleoside transporters activity in the
rat hippocampus. J Neurochem. , 93, 595-604.
155. CUNHA-REIS, D., SEBASTIÃO, A.M. WIRKNER, K. ILLES, P. & RIBEIRO,
J.A. (2004). VIP enhances both pre- and postsynaptic GABAergic transmission to
hippocampal interneurones leading to increased excitatory synaptic transmission
to CA1 pyramidal cells. Br J Pharmacol., 143:733-744.
154. CANAS, N., PEREIRA, I.T., RIBEIRO, J.A. & SEBASTIÃO, A.M. (2004)
Brain-derived neurotrophic factor facilitates glutamate and inhibits GABA release
from hippocampal synaptosomes through different mechanisms. Brain Res 1016,
72-78
153. ILLES, P & RIBEIRO, J.A. (2004). Neuronal P2 receptors of the central nervous
system. Cur Topics Med Chem, 4, 831-838.
152. DIÓGENES, M.J., FERNANDES, C.C., SEBASTIÃO, A.M. & RIBEIRO, J.A.
(2004). Activation of adenosine A2A receptor facilitates BDNF modulation of
synaptic transmission in hippocampal slices. J. Neurosci., 24, 2905-2913.
151. ILLES, P & RIBEIRO, J.A. (2004). Molecular physiology of P2 receptors in the
central nervous system. Eur J Pharmacol., 483, 5-17.
150. CUNHA, R.A., RIBEIRO, J.A. & MALVA, J.O. (2004). Presynaptic kainate
receptors modulating glutamatergic transmission in the rat hippocampus are
inhibited by arachidonic acid. Neurochem. Int., 44, 371-379.
149. ALMEIDA T, RODRIGUES RJ, de MENDONCA A, RIBEIRO JA, CUNHA
RA. (2003). Purinergic P2 receptors trigger adenosine release leading to adenosine
A(2A) receptor activation and facilitation of long-term potentiation in rat
hippocampal slices. Neuroscience. 122:111-121.
148. RIBEIRO, J.A, (2003) Fine tuning modulation of neurotransmission. J. Vet.
Pharmacol. & Ther., 26, 6-11.
147. RIBEIRO, J.A, SEBASTIÃO, A.M. de MENDONÇA, A., (2003). Participation
of adenosine receptors in neuroprotection Drug news & perspectives, 16, 80-86.
146 RIBEIRO, J.A. LOBO M.G.B. & SEBASTIÃO, A.M. (2003 ). Endogenous
adenosine modulation of 22Na uptake by rat brain synaptosomes.Neurochem
Res, 28, 1589-1593.
145. ALMEIDA, C. G., de MENDONÇA, A., CUNHA, R.A. & RIBEIRO, J.A.
(2003). Adenosine promotes neuronal recovery from reactive oxygen species
induced lesion in rat hippocampal slices. Neurosci. Lets, 339, 127-130.
144. REBOLA, N., SEBASTIÃO, A.M., de MENDONÇA, A., OLIVEIRA, C.R., RIBEIRO, J.A. & CUNHA, R.A, (2003). Enhanced adenosine A2A receptor
facilitation of synaptic transmission in the hippocampus of aged rats.J
Neurophysiol., 90, 1295-1303.
143. LOPES, L.V., REBOLA, N., COSTENLA A.R., HALLDNER, L., JACOBSON, M.A., OLIVEIRA, C.R., RICHARDSON, P.J., FREDHOLM, B.B., RIBEIRO, J.
A. & CUNHA, R.A. (2003). Adenosine A3 receptors in the rat hippocampus: lack
of interaction with A1 receptors. Drug Develop. Res., 58, 428-438.
142. MAGALHÃES-CARDOSO, M.T., PEREIRA, M:F., OLIVEIRA; L., RIBEIRO,
J.A., CUNHA, R.A. & CORREIA-de-SÁ, P. (2003). Ecto-AMP deaminase blunts
the ATP-derived adenosine A2A receptor facilitation of acetylcholine release at
rat motor nerve endings. J. Physiol.Lond., 549, 399-408.
141. RIBEIRO, J.A, SEBASTIÃO, A.M. de MENDONÇA, A., (2003). Adenosine
receptors in the nervous system: pathophysiological implications. Prog.
Neurobiol. 68, 377-392.
140. CASCALHEIRA, J.F., SEBASTIÃO, A.M. & RIBEIRO, J.A. (2002). Pertussis
toxin-sensitive G proteins mediate the inhibition of basal phosphoinositide
metabolism caused by adenosine A1 receptors in rat hippocampal slices.
Neurochem. Res., 27, 1707-1711.
139. LOPES, L.V., CUNHA, R.A., KULL, B., FREDHOLM, B.B. & RIBEIRO, J. A.
(2002). Adenosine A2A receptor facilitation of hippocampal synaptic
transmission is dependent on tonic A1 receptor inhibition. Neuroscience, 112,
319-329.
138. CUNHA, R.A., COELHO, J. E., COSTENLA, A.R., LOPES, L. V., PARADA, A. de MENDONÇA, A., SEBASTIÃO, A.M. & RIBEIRO, J.A. (2002). Effects of
carbamazepine and novel 10, 11-dihydro-5H-dibenz(b,f)azepine-5-carboxamide
derivatives on synaptic transmission in rat hippocampal slices. Pharmacol. &
Toxicol., 90, 208-213.
137. DIAZ-HERNANDEZ, M., PEREIRA, M.F., PINTOR, J., CUNHA, R.A., RIBEIRO, J.A., & MIRAS-PORTUGAL, M.T., (2002). Modulation of the rat
hippocampal dinucleotide receptor by adenosine receptor activation, J
Pharmacol Exp Ther.; 301: 441-50.
136. de MENDONÇA, A.COSTENLA, A.R. & RIBEIRO, J. A. (2002). Persistence of
the neuromodulatory effects of adenosine on synaptic transmission after long-term
potentiation and long-term depression. Brain Res., 932, 56-60.
135. SEBASTIÃO, A.M., DE MENDONÇA, A., MOREIRA, T. & RIBEIRO, J.A.
(2001). Activation of synaptic NMDA receptors by action potential-dependent
release of transmitter during hypoxia impairs recovery of synaptic transmission
upon reoxygenation. J. Neurosci., 21, 8564-8571.
134. CORREIA-DE-SÁ, P., TIMÓTEO, M.A. & RIBEIRO, J.A. (2001). Synergism
between A2A-adenosine receptors activation and vasoactive intestinal peptide to
facilitate 3H-acetylcholine release from the rat motor nerve terminals. Neurosci.
Letts, 309, 101-104.
133. RIBEIRO, J.A., CUNHA-REIS, D., LOPES, L.V., COELHO, J.E., COSTENLA,
A.R., CORREIA-DE-SÁ, P., CUNHA, R.A., de MENDONÇA, A. &
SEBASTIÃO, A.M. (2001). Adenosine receptor interactions in the hippocampus.
Drug Develop. Res., 52, 337-345.
132. SEBASTIÃO, A.M., DE MENDONÇA, A. & RIBEIRO, J.A. (2001)
Neuroprotection during hypoxic insults: role of adenosine. Drug Dev. Res., 52,
291-295.
131. DE MENDONÇA, A. & RIBEIRO, J. A. (2001). Adenosine and Synaptic
Plasticity. Drug Dev. Res., 52, 283-290.
130. COSTENLA, A.R., LOPES, L.V., de MENDONÇA, A. & RIBEIRO, J.A.
(2001). A functional role for adenosine A3 receptors: modulation of synaptic
plasticity in the rat hippocampus Neurosci. Letts, 302, 53-57.
129. CUNHA, R.A., CONSTANTINO, M.D., FONSECA, E. & RIBEIRO, J.A.
(2001). Age-dependent effects of cis-unsaturated free fatty acids on adenosine A1
receptors. Eur. J. Biochem., 268, 2939-2947.
128. CUNHA, R.A., ALMEIDA, T., & RIBEIRO, J.A. (2001). Parallel modification of
adenosine extracellular metabolism and modulatory action in the hippocampus of
aged rats. J Neurochem., 76, 372-382.
127. SEBASTIÃO, A.M. CUNHA, R.A. DE MENDONÇA, A. & RIBEIRO, J.A.
(2000). Modification of adenosine modulation of synaptic transmission in the
hippocampus of aged rats. Br. J. Pharmacol., 131, 1629-1634.
126. CUNHA, R.A., ALMEIDA, T., & RIBEIRO, J.A. (2000). Modification by
arachidonic acid of extracellular adenosine metabolism and neuromodulatory
action in the rat hippocampus J. Biol. Chem., 275, 37572-37581.
125. PEREIRA, M.F., HERNANDEZ, M.D., PINTOR, J., MIRAS-PORTUGAL, M.T., CUNHA, R.A. & RIBEIRO, J.A. (2000). Diadenosine polyphosphates facilitate
the evoked release of acetylcholine from rat hippocampal nerve terminals. Brain
Res., 879, 50-54.
124. DE MENDONÇA, A., SEBASTIÃO, A.M. & RIBEIRO, J. A. (2000) Adenosine-
does it have a neuroprotective role after all? Brain Res. Rev., 33, 258-274.
123. DE MENDONÇA, A. & RIBEIRO, J. A. (2000). Long-term Potentiation
observed upon blockade of adenosine A1 receptors in rat hippocampus is N-
methyl-D-aspartate receptor-dependent. Neurosci. Letts, 291, 81-84.
122. CORREIA-DE-SÁ, P., TIMÓTEO, M.A. & RIBEIRO, J.A. (2000). Influence of
stimulation on Ca2+ recruitment triggering 3H acetylcholine release from the rat
motor nerve endings. Eur. J. Pharmacol. , 406, 355-362.
121. SEBASTIÃO, A.M. & RIBEIRO, J.A. (2000) Fine tuning neuromodulation by
adenosine Trends Pharmacol. Sci., 21, 341-346.
120. SALGADO, A.I. CUNHA, R.A . & RIBEIRO, J. A . (2000) Facilitation by P2
receptor activation of acetylcholine release from rat motor nerve terminals:
interaction with presynaptic nicotinic receptors. Brain Res., 877, 245-250.
119. CUNHA, R.A. & RIBEIRO, J.A. (2000) Adenosine A2A receptor facilitation of
synaptic transmission in the CA1 area of the rat hippocampus requires protein
kinase C but not protein kinase A activation Neurosci. Letts, 289, 127-130.
118. CUNHA, R.A. & & RIBEIRO, J. A. (2000) ATP as a presynaptic modulator
(mini-review) Life Sci., 68, 119-137.
117. COELHO, J.E., DE MENDONÇA, A. & RIBEIRO, J. A. (2000). Presynaptic
inhibitory receptors mediate the depression of synaptic transmission upon hypoxia
in rat hippocampal slices.Brain Res., 869, 158-165.
116. CORREIA-DE-SÁ, P., TIMÓTEO, M.A. & RIBEIRO, J.A. (2000). A2A-
adenosine receptor facilitation of neuromuscuar transmission: influence of
stimulus paradigm on calcium mobilization. J Neurochem., 74, 2462-2469.
115. PEREIRA, M.F., CUNHA, R.A. & RIBEIRO, J.A. (2000). Tonic adenosine
neuromodulation is preserved in motor nerve endings of aged rats. Neurochem.
Int., 36, 563-566.
114. CUNHA, R.A. & RIBEIRO, J.A. (2000). Purinergic modulation of 3H GABA
release from rat hippocampal nerve terminals. Neuropharmacol. 39, 1156-1167.
113. CUNHA, R.A., MALVA, J.O. & RIBEIRO, J.A. (2000). Pertussis toxin prevents
presynaptic inhibition by kainate receptors of rat hippocampal 3H-GABA release.
FEBS Lett, 469, 159-162.
112. SEBASTIÃO, A.M., MACEDO, M.P. & RIBEIRO, J.A. (2000). Tonic activation
of A2A adenosine receptors unmasks, and of A1 receptors prevents, a facilitatory action of calcitonin gene-related peptide in the rat hippocampus. Brit. J.
Pharmacol., 129, 374-380.
111. HERNANDEZ, J. LAORDEN, M.L., RUIZ, F.and RIBEIRO, J. A. (2000). b,y-
Methylene ATP but not a,b-methylene ATP mimics the inhibitory effect of ATP
on ventricular automaticity Pharmacol & Toxicol., 86, 68-70.
110. CUNHA; R.A., BRENDEL; P., ZIMMERMANN, H., & RIBEIRO, J.A. (2000).
Immunologically distinct isoforms of ecto-5’-nucleotidase in nerve terminals of
different areas of the rat hippocampus J. Neurochem. 74, 334-338.
109. MONTEIRO, E.C. & RIBEIRO, J.A. (2000). Adenosine-dopamine interactions
and ventilation mediated through carotid body chemoreceptors. In: Adv. Exp.
Med. Biol., 475, 671-684.
108. COSTENLA, A.R. DE MENDONÇA, A. & RIBEIRO, J. A. (1999). Adenosine
modulates synaptic plasticity in hippocampal slices from aged rats. Brain Res.,
851, 228-234.
107. LOPES, L.V., CUNHA, R.A. & RIBEIRO, J. A. (1999). Cross Talk between A1
and A2A adenosine receptors in the hippocampus and cortex of young adult and
old rats. J. Neurophysiol., 82, 3196-3203.
106. LOPES, L.V., CUNHA, R.A. & RIBEIRO, J. A. (1999). ZM 241385, an
adenosine A2A receptor antagonist, inhibits hippocampal A1 receptor responses.
Eur J. Pharmacol., 383, 393-395.
105. LOPES, L. V., CUNHA, R.A . & RIBEIRO, J. A . (1999). Increase in the
number, G-protein coupling and efficiency of facilitatory adenosine A2A receptors in the limbic cortex, but not striatum, of aged rats. J Neurochem. 73, 1733-1738.
104. CUNHA, R.A., MALVA, J.O. & RIBEIRO, J.A. (1999). Kainate receptors
coupled to Gi/Go proteins in the rat hippocampus. Molec. Pharmacol. 56, 429-
433.
103. RIBEIRO, J.A. (1999). Adenosine A2A receptor interactions with receptors for
other neurotransmitters and neuromodulators. Eur. J. Pharmacol., 375, 101-113.
102. CUNHA, R.A., CONSTANTINO, M.D. & RIBEIRO, J.A. (1999). G-protein
coupling of CGS 21680 binding sites in the rat hippocampus and cortex is
different from that of adenosine A1 and striatal A2A receptors. Naunyn
Schmiedberg’s Arch. Pharmacol., 359, 295-302.
101. SEBASTIÃO, A.M., CUNHA, R.A., CASCALHEIRA, J.F. & RIBEIRO, J.A.
(1999). Adenine nucleotides as inhibitors of synaptic transmission: role of
localised ectonucleotidases. Prog. Brain Res., 120, 183-192.
100. CUNHA, R.A. & RIBEIRO, J.A. (1999). Facilitation of GABA release by
arachidonic acid in rat hippocampal synaptosomes. Eur. J. Neurosci., 11, 1-4.
99. ALMEIDA, T., CUNHA, R.A. & RIBEIRO, J.A. (1999). Facilitation by
arachidonic acid of acetylcholine release from the rat hippocampus. Brain Res.,
826, 104-111.
98. COSTENLA, A.R., de MENDONÇA, A., SEBASTIÃO, A., M. & RIBEIRO, J.A.
(!999). An adenosine analogue inhibits NMDA receptor-mediated responses in
bipolar cells of the rat retina. Exp. Eye Res. 68, 367-370.
97. CUNHA, J.A., SEBASTIÃO, A.M. & RIBEIRO, J. A. (1998). Inhibition by ATP
of hippocampal synaptic transmission requires localized extracellular catabolism by ecto-nucleotidases into adenosine and channeling to adenosine A1 receptors J.
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96. CUNHA, R.A., CONSTANTINO,M.D. & RIBEIRO, J.A. (1997). ZM241385 is an
antagonist of the facilitatory responses produced by the A2A adenosine receptor
agonists CGS21680 and HENECA in the rat hippocampus. Br. J. Pharmacol.,
122, 1279-1284.
95. GONÇALVES, M.L., CUNHA, R.A. & RIBEIRO, J. A. (1997). Adenosine A2A
receptors facilitate 45Ca2+ uptake through class A calcium channels in rat
hippocampal CA3 but not CA1 synaptosomes. Neurosci. Letts, 238, 73-77.
94. de MENDONÇA, A. & RIBEIRO, J. A. (1997). Contribution of metabotropic
glutamate receptors to the depression of excitatory postsynaptic potentials during
hypoxia. Neuroreport, 8, 3667-3671.
93. LOBO, M.G.B., OLIVEIRA, D. G., SEBASTIÃO, A.M. & RIBEIRO, J.A.
(1997). On the high affinity of 8-cyclohexylcaffeine for the presynaptic inhibitory
adenosine receptor present in rat motor nerve terminals. Pharmacol. & Toxicol.,
80, 295-300.
92. LORENZEN, A., SEBASTIÃO, A.M., SELLINK; A., VOGT, H., SCHWABE, U., RIBEIRO, J. A. & IJZERMAN, A:P. (1997). Biological activities of N6, C8-
disubstituted adenosine derivatives as partial agonists of rat brain adenosine A1
receptors. Eur. J. Pharmacol., 334, 299-307.
91. de MENDONÇA, A. & RIBEIRO, J. A. (1997). Influence of metabotropic
glutamate receptors agonists on the inhibitory effects of adenosine A1 receptor
activation in the rat hippocampus. Br. J. Pharmacol.,121, 1541-1548.
90. CUNHA, R.A., CONSTANTINO, M.D. & RIBEIRO, J.A. (1997). Inhibition of
[3H]GABA release by kainate receptor activation in rat hippocampal
synaptosomes. Eur. J. Pharmacol., 323, 167-172.
89. de MENDONÇA, A., ALMEIDA, T., BASHIR, Z.I. & RIBEIRO, J.A. (1997).
Endogenous adenosine attenuates long term depression and depotentiation.
Neuropharmacology, 62, 385-390.
88. de MENDONÇA, A. & RIBEIRO, J.A. (1997). Adenosine and neuronal plasticity.
Life Sci., 60, 245-251.
87. RIBEIRO, J.A., de MENDONÇA, A. CORREIA-DE-SÁ, P., CUNHA, R. &
SEBASTIÃO, A.M. (1996). Purinoceptors aqnd synaptic plasticity. Drug
Develop. Res., 39, 353-360.
86. HERNÁNDEZ, J. & RIBEIRO, J.A. (1996). Excitatory actions of adenosine on
ventricular automaticity. Trends in Pharmacol. Sci., 17, 141-144.
85. SEBASTIÃO, A.M. & RIBEIRO, J.A. (1996). A2 receptor mediated excitatory
actions of adenosine in the nervous system. Prog. Neurobiol., 48, 167-189.
84. AFONSO, F., SEBASTIÃO, A.M., PINHO, M.S., FERNANDES, P., RIBEIRO,
J.A., MATA, L.R. & GULBENKIAN, S. (1996). Calcitonin gene-related peptide
in the hamster seminal vesicle and coagulating gland: An immunohistochemical,
autoradiographical and pharmacological study. Peptides, 17, 1189-1195.
83. LUCCHI, R., LATINI, S., de MENDONÇA, A., SEBASTIÃO, A.M. & RIBEIRO,
J.A. (1996). Adenosine by activating A1 receptors prevents GABAA -mediated
actions during hypoxia in the rat hippocampus Brain Res., 732, 261-266.
82. CORREIA-DE-SÁ, P., TIMÓTEO, M.A. & RIBEIRO, J.A. (1996). Presynaptic
A1-inhibitory/A2a-facilitatory adenosine receptor activation balance depends on
motor nerve stimulation paradigm at the rat hemidiaphragm. J. Neurophysiol.,
76, 3910-3919.
81. CUNHA, R.A., VIZI, E.S., RIBEIRO, J.A. & SEBASTIÃO, A.M. (1996).
Preferential release of ATP and its extracellular catabolism as a source of
adenosine upon high but not low frequency stimulation of rat hippocampal slices.
J. Neurochem., 67, 2180-2187.
80. RIBEIRO, J.A., CUNHA, R.A., CORREIA-DE-SÁ, P. & SEBASTIÃO, A.M.
(1996). Purinergic regulation of acetylcholine release. Prog. Brain Res., 109,
231-241.
79. CUNHA, R.A., CORREIA-DE-SÁ, P., SEBASTIÃO, A.M. & RIBEIRO, J.A.
(1996). Preferential activation of excitatory adenosine receptors at rat
hippocampal and neuromuscular synapses by adenosine formed from released
adenine nucleotides. Br. J. Pharmacol., 119, 253-260.
78. GONÇALVES, M.L. & RIBEIRO, J.A. (1996). Adenosine A2-receptors activation facilitate 45Ca2+ uptake by rat brain synaptosomes. Eur. J. Pharmacol., 310, 257-
261.
77. CORREIA-DE-SÁ, P. & RIBEIRO, J.A. (1996). Adenosine uptake and
deamination regulate A2a-receptor facilitation of evoked [3H]-ACh release from
the rat motor nerve terminals. Neuroscience, 73, 85-92.
76. HERNANDEZ, J. & RIBEIRO, J.A. (1995). Adenosine and ventricular
automaticity. Life Sci., 57, 1393-1399.
75. CUNHA, R.A., CONSTANTINO, M.D., SEBASTIÃO, A.M. & RIBEIRO, J.A.
(1995). Modification of A1 and A2a receptor binding in aged striatum,
hippocampus and cortex of the rat. Neuroreport, 6, 1583-1588.
74. CUNHA; R.A., JOHANSSON, B., FREDHOLM, B.B., RIBEIRO, J.A. &
SEBASTIÃO, A.M. (1995). Adenosine A2a receptors stimulate acetylcholine
release from nerve terminals of the rat hippocampus. Neurosci. Letts, 196, 41-44.
73. de MENDONÇA, A., SEBASTIÃO, A.M. and RIBEIRO, J.A. (1995). Inhibition
of NMDA receptor-mediated currents in isolated rat hippocampal neurons by
adenosine A1 receptor activation. NeuroReport, 6, 1097-1100.
72. OLIVEIRA, J.C., CONSTANTINO, M.D., SEBASTIÃO, A.M. & RIBEIRO, J.A.
(1995). Ascorbate/Fe3+-induced peroxidation and inhibition of the binding of A1 adenosine receptor ligands in rat brain membranes. Neurochem. Int., 26, 263-
268.
71. MALVA, J.O., AMBRÓSIO, A.F., CUNHA, R.A., RIBEIRO, J.A., CARVALHO,
A.P. & CARVALHO, C.M. (1995). A functionally active presynaptic high-affinity
kainate receptor in the rat hippocampal CA3 subregion. Neurosci. Letts, 185, 83-
86.
70. RIBEIRO, J.A. (1995). Purinergic inhibition of neurotransmitter release in the
central nervous system. Pharmacol. & Toxicol., 77, 299-305.
69. HERNANDEZ, J., PINTO, F. & RIBEIRO, J.A. (1994). Involvent of α-
adrenoceptors in the excitatory effect of the A2 adenosine receptor agonist, 5’-N- ethylcarboxamide adenosine (NECA) on cardiac automaticity in the isolated right
ventricles of the rat. Naunyn-Schmiedeberg's Arch. Pharmacol., .350, 632-637.
68. CORREIA-DE-SÁ, P. & RIBEIRO, J.A. (1994). Tonic adenosine A2A receptors
activation modulates nicotinic autoreceptors function at the rat neuromuscular
junction. Eur. J. Pharmacol., 271, 349-355. .
67. CANHÃO, P., de MENDONÇA, A. & RIBEIRO, J.A. (1994). 1,3-dipropyl-8-
cyclopentylxanthine attenuates the NMDA response to hypoxia in the rat
hippocampus. Brain Res., 661, 265-273.
66. CORREIA-DE-SÁ, P. & RIBEIRO, J.A. (1994). Evidence that the presynaptic
A2a-adenosine receptor of the rat motor nerve endings is positively coupled to
adenylate cyclase. Naunyn-Schmiedeberg's Arch. Pharmacol., 350, 514-522.
65. de MENDONÇA, A. & RIBEIRO, J.A. (1994). Endogenous adenosine modulates
long-term potentiation in the hippocampus. Neuroscience, 62, 385-390.
64. CUNHA, R.A., JOHANSSON, B., van der PLOEG, I., SEBASTIÃO, A.M., RIBEIRO, J.A. & FREDHOLM, B.B. (1994). Evidence for functionally
important adenosine A2a receptors in the rat hippocampus. Brain Res., 649, 208-
216.
63. HERNANDEZ, J., PINTO, F., FIGUEIRA, M.A. & RIBEIRO, J.A. (1994).
Evidence for a cooperation between A2 receptors and β1-adrenoceptors on
cardiac automaticity in the isolated right ventricle of the rat. Br. J. Pharmacol.,
111, 1316-1320.
62. CUNHA, R.A., MILUSHEVA, E., VIZI, E.S., RIBEIRO, J.A. & SEBASTIÃO,
A.M. (1994). Excitatory and inhibitory effects of A1 and A2A adenosine receptor
activation on the electrically-evoked [3H]-acetylcholine release from different
areas of the rat hippocampus. J. Neurochem., 63, 207-214.
61. PINHO, M.S., SEBASTIÃO, A.M., RODRIGUES, G., BARROSO, C.P., RIBEIRO, J.A., MATA, L.R. & GULBENKIAN, S. (1994). Vasoactive
intestinal peptide (VIP) in the hamster seminal vesicle: distribution, binding sites
and possible functions. Neuroscience, 59, 1083-1091.
60. CORREIA-DE-SÁ, P. & RIBEIRO, J.A. (1994). Tonic A2a-adenosine receptor
activation potentiates CGRP facilitation of [3H]acetylcholine release from rat
motor nerve endings Br. J. Pharmacol., 111, 582-588.
59. CUNHA, R.A., RIBEIRO, J.A. & SEBASTIÃO, A.M. (1994). Purinergic
modulation of the evoked release of [3H]acetylcholine from the hippocampus and
cerebral cortex of the rat: role of the ecto-nucleotidases. Eur. J. Neurosci., 6, 33-
42.
58. DE MENDONÇA, A. & RIBEIRO, J.A. (1993). Adenosine inhibits the NMDA
receptor-mediated excitatory post-synaptic potential in the hippocampus. Brain
Res., 606, 351-356.
57. CORREIA-DE-SA, P. & RIBEIRO, J.A. (1993). Facilitation of [3H]-ACh release
by forskolin depends on A2 adenosine receptor activation. Neurosci. Letts, 151,
21-24.
56. OLIVEIRA, J.C., SEBASTIÃO, A.M. & RIBEIRO, J.A. (1993). On the high
affinity binding site for [3H]-1,3-dipropyl-8- cyclopentylxanthine in frog brain
membranes. Br. J. Pharmacol., 109, 518-523.
55. CUNHA, R.A., SEBASTIÃO, A.M. & RIBEIRO, J.A. (1992). Ecto-5'-
nucleotidase is associated with cholinergic nerve terminals in the hippocampus
but not in the cerebral cortex of the rat. J. Neurochem., 59, 657-666.
54. SEBASTIÃO, A.M. & RIBEIRO, J.A. (1992). Evidence for the presence of
excitatory A2 adenosine receptors in the rat hippocampus. Neurosci. Letts, 138,
41-44.
53. LOBO, M.G.B. & RIBEIRO, J.A. (1992). Effects of forskolin, dibutyryl cyclic
AMP, and 5'-N-ethylcarboxamide adenosine on 22Na uptake by rat brain
synaptosomes stimulated by veratridine. J. Neurochem., 58, 1033-1037.
52. MONTEIRO, E.C. & RIBEIRO, J.A. (1991). Adenosine and the bradycardic
response to vagus nerve stimulation. Eur. J. Pharmacol., 204, 193-202.
51. OLIVEIRA, J.C., SEBASTIÃO, A.M. & RIBEIRO, J.A. (1991). Solubilized rat
brain adenosine receptors have two high affinity binding sites for 1,3,-dipropyl-8-
cyclopentylxanthine. J. Neurochem., 57, 1165-1171.
50. CORREIA-DE-SÁ, P., SEBASTIÃO, A.M. & RIBEIRO, J.A. (1991). Inhibitory
and excitatory effects of adenosine receptor agonists on evoked transmitter release
from phrenic nerve endings of the rat. Br. J. Pharmacol., 103, 1614-1620.
49. RIBEIRO, J.A. & MONTEIRO, E.C. (1991). On the adenosine receptor involved
in the excitatory action of adenosine on respiration: antagonist profile.
Nucleosides & Nucleotides, 10, 945-953.
48. GONÇALVES, M.L., PINTO, F. & RIBEIRO, J.A. (1991). Effect of adenosine on
45Ca uptake by rat brain synaptosomes ellectrically stimulated. J. Neurochem.,
56, 1769-1773.
47. DE MENDONÇA, A. & RIBEIRO, J.A. (1990). 2-Chloroadenosine decreases
long-term potentiation in the hippocampal CA1 area of the rat. Neurosci.Letts,
118, 107-111.
46. SEBASTIÃO, A.M., STONE, T.W. & RIBEIRO, J.A. (1990). On the inhibitory
adenosine receptor at the neuromuscular junction and hippocampus of the rat:
antagonism by 1,3,8-substituted xanthines. Br.J.Pharmacol., 101, 453-459.
45. SEBASTIÃO, A.M. & RIBEIRO, J.A. (1990). Interactions between adenosine and
phorbol esters or lithium at the frog neuromuscular junction. Br.J.Pharmacol.,
100, 55-62.
44. DELICADO, E.G., RODRIGUES, A., SEN, R.P., SEBASTIÃO, A.M., RIBEIRO,
ethylcarboxamidoadenosine (NECA) on adenosine transport in cultured
chromaffin cells. J.Neurochem., 54, 1941-1946.
43. CUNHA, R.A., SEBASTIÃO, A.M. & RIBEIRO, J.A. (1989). Separation of
adenosine triphosphate and its degradation products in innervated muscle of the frog Chromatographia, 28, 610-612.
42. MONTEIRO, E.C. & RIBEIRO, J.A. (1989). Inhibition by 1,3- dipropyl-8-(p-
sulfophenyl)xanthine of the respiratory stimulation induced by common carotid
occlusion in rats. Life Sci., 45, 939-945.
41. MONTEIRO, E.C. & RIBEIRO, J.A. (1989). Adenosine deaminase and adenosine
uptake inhibitons facilitate ventilation in rats. Naunyn-Schmiedeberg's
Arch.Pharmacol., 340, 230-238.
40. DE MENDONÇA, A. & RIBEIRO, J.A. (1989). Diazepam enhances the inhibitory
action of adenosine on transmission at the frog neuromuscular junction.
Eur.J.Pharmacol., 164, 347-354.
39. HERNANDEZ, J. LAORDEN, M.L., RUIZ, F. & RIBEIRO, J.A. (1989). Effects
of adenosine and its analogues on ventricular automaticity induced by a local
injury: role of catecholamines and of cyclic AMP. Arch.int.Pharmacodyn., 297,
49-59.
38. SEBASTIÃO, A.M. & RIBEIRO, J.A. (1989). 1,3,8- and 1,3,7- substituted
xanthines: relative potency as adenosine receptor antagonists at the frog
neuromuscular junctions. Br.J.Pharmacol., 96, 211-219.
37. RUIZ, F., HERNANDEZ, J. & RIBEIRO, J.A. (1988). Theophylline antagonizes
the effect of diazepam on ventricular automaticity. Eur.J.Pharmacol., 155, 205-
209.
36. SEBASTIÃO, A.M. & RIBEIRO, J.A. (1988). On the adenosine receptor and
adenosine inactivation at the rat diaphragm neuromuscular junction.
Br.J.Pharmacol., 94, 109-120.
35. SIMÕES, A.P., OLIVEIRA, P.C., SEBASTIÃO, A.M. & RIBEIRO, J.A. (1988).
N6-cyclohexyladenosine inhibits veratridine- stimulated 22Na uptake by rat brain
synaptosomes. J.Neurochem., 50, 899-903.
34. GONÇALVES, M.L. & RIBEIRO, J.A. (1987). The effects of purines and
forskolin on haemolysis. Fundamental and Clinical Pharmacology, 1, 169-178.
33. MONTEIRO, E.C. & RIBEIRO, J.A. (1987). Ventilatory effects of adenosine
mediated by carotid body chemoreceptors in the rat. Naunyn Schmiedeberg's
Arch.Pharmacol., 335, 143-148.
32. RIBEIRO, J.A. & SEBASTIÃO, A.M. (1987). On the role, inactivation and origin
of endogenous adenosine at the frog neuromuscular junction. J.Physiol.Lond.,
384, 571-585.
31. MCQUEEN, D.S. & RIBEIRO, J.A. (1986). Pharmacological characterization of
the receptor involved in the chemoexcitation induced by adenosine.
Br.J.Pharmacol., 88, 615-620.
30. LAORDEN, M.L., HERNANDEZ, J. & RIBEIRO, J.A. (1986). The effects of
adenosine, ATP and ADP on ventricular automaticity induced by a local injury in
the isolated right ventricle of the rat. Arch.int.Pharmacodyn., 279, 258-267.
29. RIBEIRO, J.A. & SEBASTIÃO, A.M. (1986). Adenosine receptors and calcium:
basis for proposing a third (A3) adenosine receptor. Prog.Neurobiol., 26, 179-
209.
28. SEBASTIÃO, A.M. & RIBEIRO, J.A. (1985). Enhancement of transmission at the
frog neuromuscular junction by adenosine deaminase: evidence for an inhibitory
role of endogenous adenosine on neuromuscular transmission. Neurosci.Letts.,
62, 267-270.
27. FIGUEIRA, M.A. & RIBEIRO, J.A. (1985). Separation by thin layer
chromatography of adenosine and its derivatives using silica gel.
J.Chromatography, 325, 317-322.
26. RIBEIRO, J.A. & SEBASTIÃO, A.M. (1985). Inhibitory effects of forskolin and
papaverine on nerve conduction partially blocked by tetrodotoxin in the frog
sciatic nerve. Br.J.Pharmacol., 85, 309-313.
25. RIBEIRO, J.A. & LIMA, M.S. (1985). The hypotensive effect of intracarotid
injections of adenosine triphosphate depends on its hydrolysis to adenosine.
Pharmacol.Res.Com., 17, 255-260.
24. RIBEIRO, J.A. & SEBASTIÃO, A.M. (1985). On the type of receptor involved in
the inhibitory action of adenosine at the neuromuscular junction.
Br.J.Pharmacol., 84, 911-918.
23. RIBEIRO, J.A. & SEBASTIÃO, A.M. (1984). Enhancement of tetrodotoxin-
induced axonal blockade by adenosine, adenosine analogues, dibutyryl cyclic
AMP and methylxanthines in the frog sciatic nerve. Br.J.Pharmacol., 83, 485-
492.
22. RIBEIRO, J.A. & SA-ALMEIDA, A.M. (1984). Excitatory effects of dibutyryl
cyclic AMP, noradrenaline and theophylline on 45Ca uptake by synaptosomes
from rat brain. Arch.int.Pharmacodyn., 270, 215-321.
21. RIBEIRO, J.A. & SEBASTIÃO, A.M. (1984). Antagonism of tetrodotoxin- and
procaine-induced axonal blockade by adenine nucleotides in the frog sciatic nerve.
Br.J.Pharmacol., 81, 277-282.
20. RIBEIRO, J.A. (1984). A acção excitatória do ATP na actividade quimio receptora
do corpo carotídeo depende da sua hidrólise prévia em adenosina. J. Fisiol.Biof.,
3, 35- 44.
19. McQUEEN, D.S. & RIBEIRO, J.A. (1983). On the specificity and type of receptor
involved in carotid body chemoreceptor activation by adenosine.
Br.J.Pharmacol., 80, 347-354.
18. McQUEEN, D.S. & RIBEIRO, J.A. (1983). Effects of ouabain on carotid body
chemoreceptor activity in the cat. J.Physiol.Lond., 335, 221-235.
17. RIBEIRO, J.A. (1982). The decrease on neuromuscular transmission by adenosine
depends on previous neuromuscular depression. Arch.int.Pharmacodyn., 255,
59-67.
16. McQUEEN, D.S. & RIBEIRO, J.A. (1981). Effect of adenosine on carotid body
chemoreceptor activity in the cat. Br.J.Pharmacol., 74, 129-136.
15. RIBEIRO, J.A. (1981). The modulation of transmission by purinergic substances at
the neuromuscular junction. Ann.N.Y.Acad.Sci., 377, 874-876.
14. RIBEIRO, J.A., DOMINGUEZ, M.L., SA-ALMEIDA, A.M. & GONÇALVES,
M.J. (1981). The effects of imidazole on neuromuscular transmission and on
synaptosomal calcium uptake in the rat. Arch.int.Pharmacodyn., 251, 260-284.
13. McQUEEN, D.S. & RIBEIRO, J.A. (1981). Effects of ß-endorphin, vasoactive
intestinal polypeptide and cholecystokinin octapeptide on cat carotid body
chemoreceptor activity. Quarterly J.exp.Physiol., 66, 273-284.
12. McQUEEN, D.S. & RIBEIRO, J.A. (1980). Inhibitory actions of methionine-
enkephalin and morphine on the cat carotid body chemoreceptors.
Br.J.Pharmacol., 71, 297-305.
11. PERES-GOMES, F. & RIBEIRO, J.A. (1979). Modification of the cardiotoxic
effects of ouabain by acepromazine, tetrodotoxin and magnesium sulphate.
Pharmacology, 18, 80-90.
10. RIBEIRO, J.A. (1979). Purinergic modulation of transmitter release.
J.Theor.Biol., 80, 259-270.
9. RIBEIRO, J.A., SA-ALMEIDA, A.M. & NAMORADO, J.M. (1979). Adenosine
and adenosine triphosphate decrease 45Ca uptake by synaptosomes stimulated by
potassium. Biochem.Pharmacol., 28, 1297-1300.
8. RIBEIRO, J.A., DOMINGUEZ, M.L. & GONÇALVES, M.J. (1979). Purine effects
at the neuromuscular junction and their modification by theophylline, imidazole
and verapamil. Arch.int.Pharmacodyn., 238, 206-219.
7. RIBEIRO, J.A. (1978). ATP, related nucleotides and adenosine on
neurotransmission. Life Sci., 22, 1373-1380.
6. RIBEIRO, J.A. & DOMINGUEZ, M.L. (1978). Mechanisms of depression of
neuromuscular transmission by ATP and adenosine. J.Physiol.Paris, 74, 491-496.
5. RIBEIRO, J.A. & PERES-GOMES, F. (1977). Acetylcholine release in
cerebrospinal fluid by ouabain. Neuropharmacology, 16, 695-698.
4. RIBEIRO, J.A. (1976). Effects of ouabain on arterial pressure and its modification
by tetrodotoxin. J.Pharmac.Pharmacol., 28, 847-848.
3. RIBEIRO, J.A. & WALKER, J. (1975). The effects of adenosine triphosphate and
adenosine diphosphate on transmission at the rat and frog neuromuscular
junctions. Br.J.Pharmacol., 54, 213-218.
2. RIBEIRO, J.A. & WALKER, J. (1973). Action of adenosine triphosphate on
endplate potentials recorded from muscle fibres of the rat-diaphragm and frog
sartorius. Br.J.Pharmacol., 49, 724-725.
1. RIBEIRO, J.A. (1973). Acções cardiovasculares da ubaína mediadas pelo sistema
nervoso central. J.Soc. Ciências Méd, Lisboa, 137, 319-344.

Letters to the editor (refereed):
3. RIBEIRO, J.A. & SEBASTIÃO, A.M. (1994). Further evidence for adenosine A3
receptors. Trends in Pharmacol.Sci., 15, 13.
2. RIBEIRO, J.A. & SEBASTIÃO, A.M. (1988). Is inhibition of neurotransmitter
release mediated by A3 receptors? Subtypes of adenosine receptors. Trends in
Pharmacol.Sci., 9, 279-280.
1. RIBEIRO, J.A. (1977). Potentiation of post-junctional cholinergic sensitivity of rat
diaphragm muscle by high- energy phosphate adenine nucleotides. J. Membrane
Biol., 33, 401-402.

Chapters in books:

32. RIBEIRO, J.A. (2008). Como a Ubaína uniu o Grupo do Professor Fernando Peres
Gomes no Instituto Gulbenkian De Ciencia: Um tributo à Professora Tice Anastácio de Macedo. Pp 75-86. Coimbra 31 RIBEIRO, J.A. (2004). The Role of Adenosine as a Mediator of Cerebral
Circulationl. In: Circulation, ed., M.V. Alves and A. Barbosa, pp 130-137.
Museu de Medicina, Faculdade de Medicina de Lisboa.
30. RIBEIRO, A. (2004). General aspects of neuropharmacology in relation to brain
repair following trauma. In: Brain Damage and Repair, Ed.T. Herdegen and
J.M. Delgado-Garcia, pp 423-437. Kluwer Academic Publishers, The
Netherlands.
29. de MENDONÇA, A & RIBEIRO, J.A. (2001). Adenosine and neuroprotection.
Arq. Port. Oftalmol.
28. RIBEIRO, J.A. (2000). Psicofarmacologia na disfunção sexual:introdução. In:
Sexualidade, pp. 129-131, Edit. A.Barbosa e J. Gomes-Pedro, Dep. Educação
Médica, FML, Lisboa
27. SEBASTIÃO, A.M. e RIBEIRO, J.A. (2001). Sistema Purinérgico In: Terapêutica
Medicamentosa e suas Bases Farmacológicas, ed., W. Osswald and S.
Guimarães, pp 440-451. Porto Editora, Porto.
26. RIBEIRO, J.A. (2001). Estimulantes do Sistema Nervoso Central. Antagonistas
dos receptores da adenosina: Alquilxantinas In: Terapêutica Medicamentosa e
suas Bases Farmacológicas, ed., W. Osswald and S. Guimarães, pp 139-146,
Porto Editora, Porto.
25. LOPES, L:V., CUNHA, R. A. & RIBEIRO, J.A. (1999) Interaction between adenosine A1 and A2A receptors in the control of neurotransmitter release. In:
Recent Research Developments in Neurochemistry, vol 2, part II, ed. S.J.
Pandalai, Research Signpost, Trivandrum, 463-472.
24. SEBASTIÃO, A.M., LUCCHI, R., LATINI, S., DE MENDONÇA, A. & RIBEIRO, J.A. (1997). Functional negative interaction between adenosine (A1)
and GABA (GABA A) during hypoxia in the rat hippocampus. In: The Role of
Adenosine in the Nervous System, ed. Y. Okada, pp.177-184, Elsevier Science
B.V., Amsterdam
23. DE MENDONÇA, A. & RIBEIRO, J.A. (1997). Endogenous adenosine attenuates
long-term depression in the hippocampus. In: The Role of Adenosine in the
Nervous System, ed. Y. Okada, pp.121-125, Elsevier Science B.V., Amsterdam.
22. CORREIA-DE-SÁ, P., TIMÓTEO, M.A. & RIBEIRO, J.A. (1997. Adenosine
plays a key role on neuromuscular transmission to adjust the modulatory pattern
(cholinergic vs peptidergic) to the conditions of motor nerve stimulation. In: The
Role of Adenosine in the Nervous System, ed. Y. Okada, pp. 79-87, Elsevier
Science B.V., Amsterdam.
21. RIBEIRO, J.A., CORREIA-DE-SÁ, P. CUNHA, R.A. & SEBASTIÂO, A.M.
(1997). Adenosine and neurotransmitter release: inhibition and facilitation. In:
The Role of Adenosine in the Nervous System, ed. Y. Okada, pp. 13-24,
Elsevier Science B.V., Amsterdam.
20. RIBEIRO, J.A. (1996). Novas Tendências da Farmacologia. In: Livro do
Centenário do Serviço de Oftalmologia do Hospital de Santo António, Porto
19. LACKOVIC & RIBEIRO, J.A. (1996). CNS regulation of the autonomic nervous
system. In report on Neurosciences Research in Europe.
18. WHITE, T.D., RIBEIRO, J.A., EDWARDS, F.A., FREDHOLM, B.B. & PHILLIS,
J.W. (1995). Role of purines in the central nervous system. In: Pharmacological
Sciences: Perspectives for Research and Therapy in the late 1990s, ed. A.C.
Cuello and B. Collier, pp.295-302, Birkhauser Verlag, Basel.
17. SEBASTIÃO, A.M., CUNHA, R.A., CORREIA-DE-SÁ, P., de MENDONÇA, A. & RIBEIRO, J.A. (1995). Role of A2a receptors in the hippocampus and motor
nerve endings. In: Adenosine and Adenine Nucleotides: from molecular
Biology to Integrative Physiology, ed. L. Belardinelli and A. Pelleg, pp.251-
261,Kluwer Academic Publishers , Boston.
16. RIBEIRO, J.A. (1994). Purinas In: Terapêutica Medicamentosa e suas Bases
Farmacológicas, ed. J. Garrett, W. Osswald and S. Guimarães, vol. I, pp. 452-
460, Porto Editora, Porto.
15. RIBEIRO, J.A. (1994). Alquilxantinas. In: Terapêutica Medicamentosa e suas
Bases Farmacológicas, ed. J. Garrett, W. Osswald and S. Guimarães, vol. I, pp.
156-164, Porto Editora, Porto.
14. RIBEIRO, J.A. & SEBASTIÃO, A.M. (1991). Purinergic modulation of
neurotransmitter release in the peripheral and central nervous systems. In:
Presynaptic Regulation of Neurotransmitter Release: A Handbook, ed. J.
Feigenbaum and M. Hanani, vol. I, pp.451-495, Freund Publishing House, Ltd,
London.
13. RIBEIRO, J.A. (1991). Adenosine and the central nervous system control of
autonomic function. In: Adenosine in the Nervous system, ed. T.W. Stone,
Chapter 11, pp. 229-246, Academic Press, London.
12. RIBEIRO, J.A. (1991). Purinergic regulation of transmitter release. In: Adenosine
and Adenine nucleotides as regulators of Cellular Function, ed. J.W. Phillis,
Chapter 12, pp.155- 167, CRC Press inc., New York.
11. RIBEIRO, J.A., CORREIA-DE-SÁ, P., CUNHA, R.A., OLIVEIRA, J.C. &
SEBASTIÃO, A.M. (1991). Role of adenosine at the neuromuscular junction:
effects mediated by presynaptic inhibitory and excitatory receptors. In: Role of
Adenosine and Adenine Nucleotides in the Biological System, ed. S. Imai and
M. Nakazawa, pp.691-702, Elsevier Sci. Publ., Amesterdam.
10. MONTEIRO, E.C. & RIBEIRO, J.A. (1990). Respiratory responses to common
carotid occlusion in the rat: Evidence for involvement of adenosine. In
Chemoreceptors and chemoreceptor reflexes, ed. H. Acker, A. Trzebski and
R.G. O'Regan, pp. 49- 56, Plenum Press, New York.
9. MONTEIRO, E.C. & RIBEIRO, J.A. (1990). Endogenous adenosine tonically
excites respiration mediated by carotid body chemoreceptors in the rat. In: Arterial Chemoreception, ed. C. Eyzaguirre, S.J. Fidone, R.S. Fitzgerald, S.
Lahiri and D.M. McDonald, pp. 174-180, Springer-Verlag, New York.
8. RIBEIRO, J.A. & SEBASTIÃO, A.M. (1990). Adenosine receptors mediating
inhibition of peripheral and central neurons. In: Purines in Cellular Signalling:
Targets for New Drugs, ed. K.A. Jacobson, J.W. Daly and V. Manganiello,
pp.166-173, Springer Verlag, New York.
7. RIBEIRO, J.A. & SEBASTIÃO, A.M. (1989). Characterization of the adenosine
receptor that mediates inhibition of transmitter release at the frog neuromuscular
junction. In:Adenosine Receptors in the Nervous System, ed. J.A. Ribeiro, pp.
69-77, Taylor & Francis, London.
6. RIBEIRO, J.A., MONTEIRO, E.C. & McQUEEN, D.S. (1988). The actions of
adenosine on respiration. In: Adenosine and Adenine Nucleotides. Physiology
and Pharmacology, ed. D.M. Paton, pp.225-232, Taylor & Francis, London.
5. RIBEIRO, J.A. & SEBASTIÃO, A.M. (1987). Adenosine, cyclic AMP and nerve
conduction. In: Topics and Perspectives in Adenosine Research, eds. E.
Gerlach and B.F. Becker, pp. 559- 573, Springer-Verlag, Berlin.
4. RIBEIRO, J.A. & McQUEEN, D.S. (1987). Chemoexcitation evoked by adenosine:
pharmacological characterization of the receptor. In: Chemoreceptors in
Respiratory Control, eds J.A. Ribeiro and D.J. Pallot, pp. 305-313, Croom
Helm, London.
3. MONTEIRO, E.C. & RIBEIRO, J.A. (1987). Adenosine modulation of respiration
mediated by carotid body chemoreceptors. In: Chemoreceptors in Respiratory
Control, eds J.A. Ribeiro and D.J. Pallot, pp. 314-321, Croom Helm, London.
2. RIBEIRO, J.A. & McQUEEN, D.S. (1984). Effects of purines on carotid body
chemoreceptors. In: The peripheral chemoreceptors, ed. D.J. Pallot, pp.383-
390, Croom Helm, London.
1. RIBEIRO, J.A. & McQUEEN, D.S. (1983). On the neuromuscular depression and
carotid body chemoreceptor activation caused by adenosine. In. Physiology and
Pharmacology of Adenosine Derivatives, eds J.W. Daly, Y. Kuroda, J.W.
Phillis, H. Shimizu & M. Ui., pp. 179-188. Raven Press, New York.

Edition of books:
2. Adenosine Receptors in the Nervous System, ed. J.A. Ribeiro, Taylor & Francis,
1. Chemoreceptors in Respiratory Control, ed. J.A. Ribeiro and D.J. Pallot, Croom

Other papers:

6. RIBEIRO, J.A. (2006). Neuroética, a emergência de uma nova disciplina em
Neurociências. e.Ciência (on line).
5 RIBEIRO, J.A. (1991). Biological basis of the hemodynamic actions of adenosine.
Rev. Port. Hemor., 5, 189-193.
4 RIBEIRO, J.A. (1989). Adenosine receptors; classification and properties. Revista
do Hospital S. Paulo, 1, 5-6.
3 RIBEIRO, J.A. (1989). Mecanismos de acção das alquilxantinas. Arq. Inst.
Farmacol. Ter. Exp., Coimbra, 25, 255-282.
2 RIBEIRO, J.A. (1986). Neurotransmissores putativos purinérgicos e peptidérgicos do
sistema nervoso entérico. Rev. Gastroenterol., 3, 273-283.
1 RIBEIRO, J.A. (1984). On a new class of putative neurotransmitters in the carotid
body. Arq. Inst. Farmacol. Ter. Exp., Coimbra, 22, 17-70.

Abstracts published related to communications presented at national and
international meetings (journals and books of proceedings) > 500

REFEREE

1988-2008 Scientific Consultant and member of several scientific and organizing
committees of international meetings held in U.S.A., Japan and Europe.
-Scientific journals, grants, and promotions

Promotion to a Senior position of the University of Cambridge Promotion to Associate Professor of Yale University School of Medicine Promotion to a Senior Professor of The Northwestern University of Chicago Promotion to Senior Scholar of a Professor of the Wayne State University of Detroit, USA. Promotion to Senior Scientist of National Institute of Health (USA). Referee for the Steacie Prize, Steacie Foundation and National Research Wellcome Trust Grants, U.K. Human Frontier Project Grants and Fellowships NATO Fellowships and Grant Applications External examiner of Ph. D. thesis at the University of Murcia, Madrid and Melbourne Eur. J. Neurosci
J. Neurosci.
Eur. J. Pharmacol
J. Physiol. London
Biochem. Pharmacol.
J. Pharmacol. Exp. Ther.
J. Neurochem.
Pharmacol & Toxicol.
Neuroscience
Naunyn Schmiedberg´s Arch. Pharmacol.
Life Sci.
Neuroscience Letters
Journal of Autonomic Pharmacology
Biochimica and Biophisica Acta
British Journal of Pharmacology
Psychopharmacology
Hippocampus
Journal de Physiologie, Paris
BIOMED II (evaluation)
HFSO reviewer (grants) EEC reviewer (grants for BIOMED 1).
MEMBERSHIP OF SCIENTIFIC SOCIETIES AND OFFICES HELD
1997/99 - President of the Portuguese Society for Neuroscience
1991/94 - President of the Portuguese Pharmacological Society
1989/91 - Vice-President of the Portuguese Pharmacological Society
1986 - IUPHAR delegate of the Portuguese Pharmacological Society
1985/92 - Vice-President of the Portuguese Society for Neurochemistry
British Pharmacological Society
International Society for Neurochemistry
European Society for Neurochemistry
European Neuroscience Association
International Society for Arterial Chemoreception (ISAC)
Society for Experimental Biology
Portuguese Pharmacological Society
Portuguese Society for Neurochemistry
American Society for Neurochemistry
Portuguese Society for Neuroscience
HONERS AND AWARDS
1972 - Pfizer Prize for Young Investigators
1983 - Lepetit Prize of the Portuguese Physiological Society
1993 – Prémio Egas Moniz/Boehringer Ingelheim
1995 - Honours of Prémio da Boa Esperança
1997 - Portuguese Pharmacological Society Prize
2000 – Elected Acedemico Correspondente da Academia Portuguesa de Medicina
2002 - Pfizer Prize (honours)
2002 – Elected Member of EDAB (European Dana Alliance for Brain Initiatives)
2005 – ‘Estímulo à Excelência’, FCT
2006 – Elected Acedemico Correspondente da Real Academia de Farmacia, Spain
2007 – Elected Acedemico Efectivo da Academia Portuguesa de Medicina
2008 – Elected Member of the International Scientific Board of “Real Academia de

NUMBER OF CITATIONS (according ISI Web of Knowlrdge)

Till September 2010: 5 744 (includes auto-citations), H: 43
Up to 2010 included in the 1% of the most cited scientists in the world, in the last 10 years,
(according to ISI Web of Knowledge) in the area of PHARMACOLOGY.

Source: http://neurociencias.pt/CV/JAR_CV.pdf