SIGMA-ALDRICH sigma-aldrich.com Material Safety Data Sheet
1. PRODUCT AND COMPANY IDENTIFICATION
Sigma-Aldrich Manufacturer : Sigma-Aldrich Corporation 3050 Spruce Street
both supplier and manufacturer) Preparation Information
Product Safety - Americas Region 1-800-521-8956
2. HAZARDS IDENTIFICATION Emergency Overview OSHA Hazards Target Organ Effect, Toxic by ingestion, Irritant Target Organs GHS Classification Acute toxicity, Oral (Category 3) Skin irritation (Category 2) Eye irritation (Category 2A) Specific target organ toxicity - single exposure (Category 3) GHS Label elements, including precautionary statements
Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray.
IF SWALLOWED: Immediately call a POISON CENTER or doctor/ physician.
IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
HMIS Classification Health hazard:
Sigma - A2093 Chronic Health Hazard: Flammability: Physical hazards: NFPA Rating Health hazard: Reactivity Hazard: Potential Health Effects Inhalation
May be harmful if inhaled. Causes respiratory tract irritation.
May be harmful if absorbed through skin. Causes skin irritation.
Ingestion
4. FIRST AID MEASURES General advice Consult a physician. Show this safety data sheet to the doctor in attendance.Move out of dangerous area. If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Take victim immediately to hospital. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.
5. FIRE-FIGHTING MEASURES Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Special protective equipment for fire-fighters Wear self contained breathing apparatus for fire fighting if necessary. Hazardous combustion products Hazardous decomposition products formed under fire conditions. - Carbon oxides
6. ACCIDENTAL RELEASE MEASURES Personal precautions Wear respiratory protection. Avoid dust formation. Avoid breathing vapors, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust.
Sigma - A2093 Environmental precautions Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Methods and materials for containment and cleaning up Pick up and arrange disposal without creating dust. Sweep up and shovel. Keep in suitable, closed containers for disposal.
7. HANDLING AND STORAGE Precautions for safe handling Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Provide appropriate exhaust ventilation at places where dust is formed. Normal measures for preventive fire protection. Conditions for safe storage Keep container tightly closed in a dry and well-ventilated place.
8. EXPOSURE CONTROLS/PERSONAL PROTECTION Components with workplace control parameters
USA. OSHA - TABLE Z-1 Limits for Air Contaminants -
Personal protective equipment Respiratory protection Where risk assessment shows air-purifying respirators are appropriate use a full-face particle respirator type N99 (US) or type P2 (EN 143) respirator cartridges as a backup to engineering controls. If the respirator is the sole means of protection, use a full-face supplied air respirator. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU). Hand protection Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. Eye protection Face shield and safety glasses Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin and body protection Complete suit protecting against chemicals, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Hygiene measures Avoid contact with skin, eyes and clothing. Wash hands before breaks and immediately after handling the product.
9. PHYSICAL AND CHEMICAL PROPERTIES Appearance Safety data
Sigma - A2093
Melting point/range: 134 - 136 °C (273 - 277 °F) - lit.
10. STABILITY AND REACTIVITY Chemical stability Stable under recommended storage conditions. Possibility of hazardous reactions no data available Conditions to avoid no data available Materials to avoid Strong oxidizing agents, Strong acids, Strong bases Hazardous decomposition products Hazardous decomposition products formed under fire conditions. - Carbon oxides Other decomposition products - no data available Thermal decomposition 140 °C
11. TOXICOLOGICAL INFORMATION Acute toxicity Oral LD50 LD50 Oral - rat - 200 mg/kg Inhalation LC50 Dermal LD50 no data available Other information on acute toxicity LD50 Intraperitoneal - rat - 340 mg/kg
LD50 Intraperitoneal - mouse - 167 mg/kg
Skin corrosion/irritation
Sigma - A2093 Serious eye damage/eye irritation no data available Respiratory or skin sensitization no data available Germ cell mutagenicity
no data available Carcinogenicity
No component of this product present at levels greater than or equal to 0.1% is identified as probable, possible or confirmed human carcinogen by IARC.
No component of this product present at levels greater than or equal to 0.1% is identified as a carcinogen or potential carcinogen by ACGIH.
No component of this product present at levels greater than or equal to 0.1% is identified as a known or anticipated carcinogen by NTP.
No component of this product present at levels greater than or equal to 0.1% is identified as a carcinogen or potential carcinogen by OSHA.
Reproductive toxicity
Overexposure may cause reproductive disorder(s) based on tests with laboratory animals.
Teratogenicity Specific target organ toxicity - single exposure (Globally Harmonized System) Inhalation - May cause respiratory irritation. Specific target organ toxicity - repeated exposure (Globally Harmonized System) no data available Aspiration hazard no data available Potential health effects Inhalation
May be harmful if inhaled. Causes respiratory tract irritation.
Ingestion
May be harmful if absorbed through skin. Causes skin irritation.
Signs and Symptoms of Exposure To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated. Synergistic effects no data available Additional Information RTECS: VO0700000
12. ECOLOGICAL INFORMATION Toxicity
LC50 - Leuciscus idus (Golden orfe) - > 1,000 mg/l - 48 h
LC50 - Bacteria - > 10,000 mg/l - 48 h
Sigma - A2093 Persistence and degradability Bioaccumulative potential no data available Mobility in soil no data available PBT and vPvB assessment no data available Other adverse effects
13. DISPOSAL CONSIDERATIONS Product Offer surplus and non-recyclable solutions to a licensed disposal company. Contact a licensed professional waste disposal service to dispose of this material. Dissolve or mix the material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber. Contaminated packaging Dispose of as unused product.
14. TRANSPORT INFORMATION DOT (US) Not dangerous goods IMDG Not dangerous goods IATA Not dangerous goods
15. REGULATORY INFORMATION OSHA Hazards Target Organ Effect, Toxic by ingestion, Irritant DSL Status All components of this product are on the Canadian DSL list. SARA 302 Components SARA 302: No chemicals in this material are subject to the reporting requirements of SARA Title III, Section 302. SARA 313 Components SARA 313: This material does not contain any chemical components with known CAS numbers that exceed the threshold (De Minimis) reporting levels established by SARA Title III, Section 313. SARA 311/312 Hazards Acute Health Hazard, Chronic Health Hazard Massachusetts Right To Know Components Pennsylvania Right To Know Components New Jersey Right To Know Components
Sigma - A2093 California Prop. 65 Components
WARNING! This product contains a chemical known to the State of
California to cause birth defects or other reproductive harm.
16. OTHER INFORMATION Further information Copyright 2011 Sigma-Aldrich Co. License granted to make unlimited paper copies for internal use only. The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. Sigma-Aldrich Co., shall not be held liable for any damage resulting from handling or from contact with the above product. See reverse side of invoice or packing slip for additional terms and conditions of sale.
Sigma - A2093
Santhera Pharmaceuticals Holding AG Santhera’s FJORD Phase IIb Study Demonstrates Efficacy of JP-1730/Fipamezole for the Treatment of Dyskinesia in Parkinson’s Disease Liestal, Switzerland, June 30, 2009 – Santhera Pharmaceuticals (SIX: SANN), a Swiss specialty pharmaceutical company focused on neuromuscular diseases, announced today positive data from its Phase I
Experiment #1: Cyclic AMP and progesterone accumulation in MA-10 cells Introduction. Cells will be incubated with buffer only or with a maximally effective concentration ofhCG. Cyclic AMP and progesterone (the main steroid product of MA-10 cells) will bemeasured as endpoints at the end of the incubation. The incubation for the cAMPassay will be done in the presence of a phosphodiesterase in
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