LIBRES Library and Information Science Research Electronic Journal Volume 18, Issue 1, March 2008
Department of Library & Information Science
510 Chung-Chen Road, Hsin-Chuang, 24205, Taiwan
Abstract
This paper reports a case integrating a problem-based learning (PBL) approach with the
“Drug & Nutrient Interactions” online course. The main objectives of this PBL
approach were to engage students in self-direction, professional reasoning, and
self-determination within an autonomous learning setting. The use of the task-oriented
learning approach in PBL encouraged students to acquire information skills, including
searching, selecting, evaluating, and using information in more meaningful ways.
Experience with a PBL approach within a Web-based learning context was obtained.
During this study, several types of interactive responses were observed, including
discussion related to case selection, information posting and sharing, defining and
finalizing, and casual chatting. With the PBL approach, students’ autonomous learning
and active involvement in self-direction, professional reasoning, and self-determination
in the Web-based interactive activities contributed to successful learning achievements.
Keywords: information skills, information literacy, problem-based learning, nutrition Introduction
Problem-based Learning (PBL) has been adopted for the preparation of professionals in
fields as diverse as medicine, engineering, law, and business. PBL seeks to engage
students in an active process of individual and cooperative learning of interrelated
themes (Valadares, 2007). Its characteristic focus on the presentation of authentic cases
as the starting point for learning has substantially enhanced students’ motivation to
learn and has augmented their ability to integrate knowledge from foundation
disciplines in pursuit of a solution to practical professional problems (Albion & Gibson,
2000; Haghparast, Sedghizadeh, Shuler, Ferati & Christersson, 2007; Valadares, 2007).
Task-oriented approaches and autonomous learning of self-direction, professional
LIBRES ISSN 1058-6768 Volume 18, Issue 1, March 2008 http://libres.curtin.edu.au/
reasoning, and self-determination are addressed as ways to foster learning in a
The PBL approach involves a task-oriented approach that occurs in a specific sequence.
First, the students identify the problem in the case provided, analyze the problem, and
develop hypotheses to account for it. Next, the students assess their own ability to solve
the problem and start collecting information from various resources. Finally, the
students discuss the problem and summarize what they have learned (Woody, Albrecht,
& Hines, 1999). Through the process of accomplishing the learning task, students
successfully develop the skills of self-directed learning, professional reasoning, and
decision-making. From an experiential learning perspective, the PBL approach is
expected to achieve a knowledge base that lasts longer than one attained purely from
In PBL, the use of learning activities often has explicit educational goals and typically
involves a task-oriented approach that organizes the curriculum around a series of cases
profiling dilemmas of practice. Student professionals read, diagnose, discuss, and
explore strategies for solving these problems (Valadares, 2007). A student-centered and
task-oriented problem-solving learning approach is consistent with the constructivist
perspective that learning is the interaction of knowing and doing (Adeogun, 2006).
Situated cognition and the notion of participation through practice offer a way of
approaching professional development (Moore & Barab, 2002).
As applied, PBL has been shown to help students develop better reasoning, critical
thinking, and communication skills as well as an increased motivation to learn. The
role of the library in its provision of electronic access to resources has become
increasingly important as learning has moved towards project work, which requires
students to find their own information using research and information searching skills
and to construct their own understanding of knowledge (McNichol, Ghelani &
Nankivell, 2002; LeBeux & Fieschi, 2007). Since searching for information by means
of the Internet is common among various health and medical professionals, providing
guidance in determining reliable sources of Internet information on various
health-related information is an area of importance (Dey, Reid, Godding & Campbell,
in press). Much attention needs to be paid to the relationship between information
provision and the development of students’ reasoning and critical thinking skills in
LIBRES ISSN 1058-6768 Volume 18, Issue 1, March 2008 http://libres.curtin.edu.au/
school and within the wider community (Lindstrom, Shonrock & Columnists, 2006).
In higher education, the development of professional thinking skills has become a
crucial part of providing fruitful learning experiences with technology
(Kasowitz-Scheer & Pasqualoni, 2002; Lindstrom, Shonrock, & Columnists, 2006). In
the day-to-day work of a PBL classroom, information technology can be used for
foraging for information or in targeting a specific knowledge area (Reznich & Werner,
2001). When searching for information to solve a problem or to answer a question,
students need to evaluate their results for quality and for relevance to the
problem/question. The use of the Internet and the skills needed for searching for
information and integrating knowledge have potential impacts on students’ learning
experiences in a PBL environment (Snavely, 2004).
Students are facing a knowledge world characterized by an explosive growth of readily
accessible information in a diverse mixture of both traditional and new formats.
Learning and reasoning from examples are important components in the development
of expertise, especially in ill-structured domains where problems are not clearly defined
and where there may be no single agreed-upon solution (Albion & Gibson, 2000). With
technology integrated in PBL, students are exposed to such various Web activities as
online discussion and conducting research. It is important to examine new
developments both for improving students’ knowledge construction and for helping
students acquire lifelong learning skills.
To provide opportunities for decision-making in a PBL environment, the Web also
offers an environment for training and experiencing. Since resources are available in all
subject areas, students can apply knowledge and learn to make decisions to solve
real-life problems (Schroeder & Zarinnia, 2001). Students today face a daily explosion
of information resources and the challenge of using these resources effectively and
responsibly. Information literacy instruction requires a shift in focus from teaching
specific information resources to teaching a set of critical thinking skills involving the
use of information (Kasowitz-Scheer & Pasqualoni, 2002). In PBL, guided through
stage-by-stage cognitive processing, students gain a deeper understanding and a
In order to enhance students’ necessary skills and knowledge in PBL, students should
be provided with opportunities to gather and analyze information concerning their
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topics, compare other cases with the specific attributes of their own problem, and
develop a best-practice approach to the task (Harwell & McCampbell, 2002). Students
need to be encouraged to take responsibility for their projects, develop a suitable plan,
and use the Internet as a research and problem-solving tool that allows information to
be retrieved quickly to facilitate both discussion among members and the synthesis of
knowledge. Several studies have shown successful integration of Web-based
technology with PBL where students were provided with self-determination
opportunities to search for solutions as well as to contact experts and to solve the
problem (Milbury & Silva, 1988; Sage, 2000; ChanLin & Chan, 2007).
The integration of Web-based technology and a PBL approach for conducting research
and solving realistic problems could potentially enrich a Web-based learning
environment. Specifically, the purposes of this research were to study students’
perceptions and experiences in the Web-based PBL context and to evaluate students’
learning development in terms of self-direction, professional reasoning, and
self-determination for accomplishing their assignment. A case study approach was
employed to observe how students learned and progressed within the task-oriented PBL
In this study, tasks were designed to encourage a sense of involvement in the use of
reference materials to solve problems. For example, for each PBL scenario, students
were requested to use references to support their assumptions and findings. The
presentation of authentic problems served as the starting point for increasing the
students’ motivation. By integrating knowledge from foundation disciplines, students
could pursue solutions to practical professional problems.
Participants were 101 college sophomores majoring in nutrition during 2006 and
enrolled in the "Drug & Nutrient Interaction" elective course. In this course, the
Web-based learning followed nine weeks of traditional lectures. To educate students to
become life-long learners and professional dieticians, it is essential to help them
understand how to access and use various Web resources and database information.
Web-based information literacy instruction regarding how to prepare a research project
and how to use academic electronic medical resources and databases was integrated
into the course. Students were provided with opportunities to search for research topics
and with information to assist in exploring the area of interest. The Web-based
instructional materials were divided into the PBL scenario—presentation of
LIBRES ISSN 1058-6768 Volume 18, Issue 1, March 2008 http://libres.curtin.edu.au/
instructional content, related resources, and information literacy in teaching library and
In teaching library and information skills, the Web-based instructional materials not
only contained links to various Web-based resources but also provided instruction in
searching related library databases such as PubMed, BioMedNet, Helix Medlin,
Medical Matrix, NLM Gateway, Biomedical Journal Title Search, Virtual Hospital,
Hardin Meta Directory of Internet Health Resources, CliniWeb, Healthwise, and
MedWeb. In addition, special databases related to the course were introduced in the
Web site. For example, the use of DRUGDEX, POISINDEX, IDENTIDEX, TOMES,
REPRORISK, AltMED, MARTINDALE, Dosing & Therapeutic Tools, INPHARMA,
and REACTIONS provided students with various options for accessing
To promote career growth and to help them become life-long learners, students were
provided with the opportunity to solve clinical problems they might encounter in the
future. Students must be able to navigate the wealth of information available online in
order to cope with clinical tasks and be successful problem solvers. In the study,
learning of information literacy was emphasized. Opportunities to allow students to
practice information skills in locating, evaluating, and using information via electronic
resources were a major component of the PBL experience.
To provide real-life experience, the Web-based learning was arranged around a
framework of problem themes geared toward developing students’ problem-solving
skills through use of a variety of resources. Students signed up in teams composed of
five to six persons for a total of 18 teams. Each team had its own discussion forum
embedded with a scoring mechanism. For each of the students’ postings, one point was
awarded automatically. Extra points (one to three) were awarded if the information
posted made a significant contribution to critical knowledge content. The process for
grading the postings provided students with an opportunity for review of their thoughts
and encouraged more constructive interactions within the groups. Remote help was also
provided when learning obstacles were observed. Students were required to use the
Web-based instruction independently but to interact with group members through
online discussion. During the learning process, each team had to decide upon a topic for
exploration related to the content area and to submit a paper to report their findings. In
this study, students’ online postings and their group projects were retained for further
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A total of 2753 messages were posted throughout the semester (March-June, 2006), and
each posting was responded to by an instructor. Throughout the learning process,
students obtained interactive feedback from experts and peers. Reconstruction of
knowledge became explicit through the multiple channels of communication. From an
instructional approach, students in the PBL environment received a case or real-life
problem. They explored and analyzed the problem and developed a reasonable
hypothesis. Through the process of exploring, searching, evaluating, and integrating
information, students experienced the virtues of PBL. From the processes used in PBL
case selection (including information searching and sharing and refinement and
finalization of their reports as shown in Table 1), students’ autonomous learning was
revealed in their effort of self-direction, professional reasoning, and self-determination
Table 1. Types of postings gathered from group discussion forums
PBL cases selection: Within an instructional setting, PBL used essential questions to
guide students to self-study the topic of interest and to set their plan for accomplishing
their assignment. When chatting about the problem cases provided in the course,
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students connected the problem scenarios to clinical cases they found on hospital Web
sites. For example, students in Group 6 related an anemia case with the use of
antibiotics for enteritis found on a hospital Web site. Several questions were used
among groups to self-explore the case, for example, “How do we approach the
problem?” “What information is needed to study the problem?” “How do we gather the
information needed?” And, “How do we integrate and report what we have found?”.
Before deciding on a topic of interest, students used the given problem scenarios to
extend the areas of observation for a particular case. Much time was spent screening
relevant information and coming up with a focus of research. Twelve out of the
eighteen groups used problem cases and proposed relevant issues for a specific area of
research. They then started gathering related information, identifying several resources
for the group members to read as well as discussing and reviewing information
Students’ discussion flow revealed that their choice of a topic for research required a
thorough analysis of problems, instructional content, and the connections between the
problem scenarios and the research materials available. The presentation of problem
scenarios in Web-based PBL instruction offered authentic learning contexts, allowing
students to have a choice in their interest area. The basic information provided in the
Web-based instructional content provided students an overview of what research areas
might be involved in a particular case. Most students were concerned with the
completion of the final projects, and their choice of a research topic for their final
project was somewhat dependent on the availability and the amount of information they
To make sure enough resources were available, students conducted a preliminary
search for relevant literatures before deciding on a research topic. If enough resources
were not found, they would give up on the problem case and consider another research
topic. Some groups (Groups 2, 4, 5, 6, 9, 17) spent long periods of time in deciding on a
research topic because they wanted to ensure that they could obtain sufficient
information to write a research paper. “Regarding our last discussion on the relationship between caffein and theophylline, the information we can get is very limited. I suggest we readjust our area of research” (Group 6).
Information searching and sharing: Students searched relevant information for two
major purposes: to decide on a topic for research and to gather further information for
the selected research topic. Students’ experience with the preliminary search was
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frequently frustrated and unsuccessful. “Too much information and too little information both bothered us” (Group 4). Online guidance was provided to help
students develop an understanding of the use of various information resources. Posting
and reviewing of relevant information among members was observed. “Too much information was covered. We need to digest before searching more information”
(Group 9). “Please read the following websites. . . . They might be helpful in understanding the relationship between statins and the cause of polymyositis.” “Here is a list of information I found related to the use of Vitamin E and Dicumarol/Digoxin. . . . Please read it. We need to get familiarized with the terms before our next search” (Group 5).
When searching information for a topic, students extended their search from the use of
commercial Web sites to professional databases and e-journals. From their searching
experiences, students learned different terminology and key words used in searching
specific drugs and nutrients. Consequently, students changed their use of terms, key
words, and search strategies to find relevant information. “We switched the terms for keywords search. Different resources were found. ” “Reading the content of specific information might help us determine which keywords to use for the next search” (Group
The ability to both search information and to retrieve relevant knowledge to understand
a problem is essential in the PBL process. Students applied the knowledge they learned
from the course content and used it as a basis for identifying relevant keywords and
terms during the search process. The more students were involved in searching and
accessing relevant resources, the more they were able to extend their understanding of
the knowledge area. More appropriate keywords and terms for further search were used
when students became better acquainted with a specific area.
Students’ involvement in the process of reviewing and selecting appropriate
information affects the quality of their work. Students were guided by their instructor
for more in-depth study of their final projects. For example, students in one group
gathered information about the “interaction of nutrients and anti-hypertension drugs.”
Suggestions were provided by the instructor for focusing on diuretics with
anti-hypertension actions that might interact with nutrients, not just a broad
introduction of all anti-hypertension drugs. Through on-going searching, accessing,
and reading of relevant resources, students extended their understanding of the
knowledge area. They also became more critical of the information resources for their
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project. “Reliable sources of information are important for preparing the project. We need to read and re-read in order to comprehend thoroughly the contents, problems, and resources obtained by team members. Information we gathered and basic knowledge obtained from online instruction provide us a basis for reasoning and making logic inferences” (Group 2). “The discussion forum is a way by which we put all pieces together and to lay out selected information for writing the project” (Group
Refinement and finalization of report: In this instance of Web-based PBL, students
developed skills through observing and analyzing a problem as well as through
evaluating relevant information for solving the problem. After searching for
information, students brought results back to the group. Students learned to apply
course content; develop critical-thinking abilities; and acquire skills of lifelong learning,
communication, and the team approach. “From cases we searched, we have observed that depression might cause abnormal food intake. However, it might not be relevant to drug and nutrient interaction.” “We need to search to determine whether there are cases related to interaction of nutrients and medications for melancholia.” “Is there a relationship between nutrients and medications for melancholia?” “Here are some cases discussing the mechanism of anti-depression” (Group 2). In preparing for their
research paper, students spent a significant amount of time and effort specifying the
problems, putting relevant information together, reviewing their own content, and
following the format requirements of professional writing. As revealed in their final
projects, students tended to study their topic of interest from a situational basis. For
example, in their discussions and reports, they occasionally used cases gathered from
newspapers/magazines or hospitals to reflect the key issue of their topics. “From the clinical cases provided, the use of newly developed antidepressant, reversible inhibitor of MAO-A(RIMA), such as moclobemide(Aurorix®) does not cause the interaction with tyamine like MAOIs do in treating patients” (Group 11). Also, students tended to draw
assumptions from different professional areas, including issues from medical science,
pharmacology, and dietetics. Different perspectives were covered before using
induction to focus on the key issues. “This is a new experience of learning that I have never had before. We have worked as a team in discussing and searching information. We know each other’s progress from the web. This type of group learning is very helpful. We share responsibility and learn from each other” (Group 6).
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Table 2. Autonomous learning from PBL approach
Relating the cases with the Using given problem
scenarios to extend the areas research; discussing cases and
self-explored cases; sharing information pertinent to
Using academic resources; Posting and reviewing of
using different terminology relevant information among
various resources including and key words; changing
journals, books, Web sites, search strategies to find
Presenting a topic of interest Reporting problems’ issues Spending more time on
from different perspectives specifying the problems,
cases; adjusting their report before focusing on the key putting relevant information
problem-solving strategies own content; drawing
help convey important ideas in observing, analyzing,
Achievement of PBL Web-Based Interaction
In the study, students’ learning outcomes were defined as intended learning resulting
from the PBL process. Student learning outcomes assessment measures whether the
learning outcomes and the set objectives are being met. From this perspective, the final
summative assessment of the project revealed that all students achieved their learning
objectives. The students’ final report was graded based on the following criteria:
content thoroughness (60%), format correctness (20%), and organization (20%). The
students’ final group reports all reached a satisfactory level, with a mean score = 79.93
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(+5.60) (Table 3). In the task-oriented learning process, students were involved in
cooperative online discussion with other team members in order to prepare their final
Table 3. Students’ Learning Outcomes for PBL
Using the PBL approach, students benefit from the interactive process of learning. In
the learning model, students worked through sequences of activities that involve
complementary thinking and problem-solving approaches. These activities achieved
their instructional purposes to (1) introduce a problem and provide motivation for
solving it by relating it to students’ experience; (2) provide pertinent resources and
opportunities for students to explore the knowledge; (3) provide guided hands-on
practice in searching and sorting relevant information; and (4) allow and encourage
cooperative effort among team members to apply the learned materials together. From
the problem-based learning activities, constructive learning was observed in various
students were presented with a challenge (problem scenario) intended to
establish a need to know the content and master the skills, including
knowledge content (drug and nutrient interactions) and information skills.
The students formulated their thoughts, reflecting on what they thought and
knew about the context of the challenge and generating ideas about the task
they were supposed to accomplish. Debates about the use of various
medications for patients in different cases reflected a form of critical thinking
Perspectives and resources were shared among team members to offer
insights and various dimensions for interpreting the information they
During the process, guidance for finding appropriate resources and feedback
for clarifying misconceptions were provided by the students’ instructor as an
on-going process accompanying students’ learning.
Assessment was carried out in which students applied what they knew and
identified what they needed to learn, including engaging in online discussion,
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In summary, the PBL approach to teaching and learning achieved its intended
objectives in the acquisition of factual knowledge, the development of problem-solving
and interpersonal skills, and the retention of knowledge. A more positive attitude
toward learning was achieved through the experiences of self-direction, professional
reasoning, and self-determination. Moreover, high-level skills in critical thinking,
useful for students in lifelong learning, were obtained.
Discussion
In PBL, the task-oriented approach reflects the key concept emphasized in inquiry
learning (Owen, Hester, & Teale, 2002; Prince & Felder, 2006). In the study, students
experienced professional reasoning as well as self-directed and self-determined
learning. It was observed that a team’s choice of topics in PBL was influenced by
considerations of various dimensions: interest in the topic, amount of information
obtained from a preliminary search on the topic, and the students’ prior knowledge of
the topic. In their research, students learned from the process of formulating questions
about the topic; gathered, sifted, and synthesized information; and systematically
presented their research report. The learning process also revealed students’
achievements in constructing their understanding of information and their efforts in
accomplishing a challenging task. The findings of this study were consistent with
Prince and Felder’s (2006) point about guided inquiry learning that uses questions and
problems to provide contexts for learning and a sufficient level of challenge to help
students develop better thinking skills and to encourage self-motivated learning.
Marcum (2002) has addressed the concept that the transformation from information to
knowledge requires students’ understanding and conceptualization of what they obtain.
Integration of library and information literacy into professional education is the key to
the successful interdisciplinary learning approach that encourages students’ use of both
knowledge areas (Lindstrom, Shonrock, & Columnists, 2006). In this study, library and
information instruction embedded in the course offered opportunities for collaboration
between library and academic efforts. From the student-centered learning perspective
of PBL, construction of knowledge counts not only for the content and meaning of the
gathered information but also for students’ management of the amount and form of
information (Schroeder & Zarinnia, 2001). Continuous feedback and guidance through
couching helped students develop their abilities in managing their own learning.
Observations of students' learning indicate that gathering sufficient information did not
necessarily mean acquisition of knowledge. Embedding literacy activities in the
LIBRES ISSN 1058-6768 Volume 18, Issue 1, March 2008 http://libres.curtin.edu.au/
context of something meaningful and interesting to students might increase the chance
Students’ involvement in the process of self-direction, professional reasoning, and
self-determination impacted the quality of their research project reports. PBL involves
more than just reporting on a topic; it requires students to move beyond the classroom
context and to employ inquiry-based learning and critical thinking. Owen, Hester, &
Teale (2002) note that when inquiry-based learning is used well, students engage in
understanding the meaningfulness and the usefulness of information. They are pushed
to expand their understandings by creating new connections. Since the ability to search
for information and apply knowledge to understand a problem were both essential in
the PBL process, students who were deeply involved in learning were more likely to
obtain required information skills, including identifying and using relevant keywords
and terms during the search process. Active participation and deep involvement were
key to achieving the main objectives of PBL and in developing the skills of
self-directed learning, professional reasoning, and decision-making within an easily
Conclusion
In this study, the use of a PBL approach provided novice students with opportunities to
participate in intellectual problem-analysis. Student professionals could acquire a
repertoire of structures and transfer a case to the framing and the solving of problems
associated with real practice. In the process of learning, students required information
skills in order to search for information relevant to their interest area. Integrating
information skills and reasoning from examples are both important components in the
development of expertise, especially in ill-structured domains where problems are not
clearly defined and where there may be no single agreed-upon solution. The PBL
Web-based learning experiences exhibited these characteristics. Students’ participating
in activities and studying problem cases were key elements in constructing knowledge
and experience. In future implementation, encouraging students’ involvement in the
activities provided in PBL is essential.
References
Adeogun, M. (2006). The challenges of a modern tertiary education system: Paradigm
shifts for educators and information professionals in sub-Saharan Africa. African Journal of Library, Archives and Information Science, 16(1), 45-52.
Albion, P. R., & Gibson, I. W. (2000). Problem-based learning as a multimedia design
LIBRES ISSN 1058-6768 Volume 18, Issue 1, March 2008 http://libres.curtin.edu.au/
framework in teacher education. Journal of Technology and Teacher Education,
ChanLin, L., & Chan, K. (2007). Integrating interdisciplinary experts for supporting
PBL. Innovations in Education and Teaching International, 44 (2), 211-224.
Dey, A., Reid, B., Godding, R., & Campbell, A. (in press). Perceptions and behaviour
of access of the Internet: A study of women attending a breast screening service in
Sydney. International Journal of Medical Informatics. Available online 9 January
Haghparast, N., Sedghizadeh, P. P., Shuler, C. F., Ferati, D., & Christersson, C. (2007).
Evaluation of student and faculty perceptions of the PBL curriculum at two dental
schools from a student perspective: A cross-sectional survey. European Journal of
Harwell, R., & McCampbell, B. (2002). Using the Internet to facilitate problem-based
learning. Principal Leadership,2(6), 63-65.
Kasowitz-Scheer, A., & Pasqualoni, M. (2002). Information literacy instruction in higher education: Trends and issues. ERIC Reproduction Service: No. ED465375.
Le Beux, P., & Fieschi, M. (2007). Virtual biomedical universities and e-learning.
International Journal of Medical Informatics,76(5-6), 331-335.
Lindstrom, J., Shonrock, D. D., & Columnists, G. (2006). Faculty-librarian
collaboration to achieve integration of information literacy. Reference & User Services Quarterly, 46(1), 18-23.
Marcum, J. W. (2002). Rethinking information literacy. The Library Quarterly, 72(1),
McNichol, S., Ghelani, T., & Nankivell, C. (2002). The role of school libraries in
resource-based learning. Education Libraries Journal, 45(3), 5-11.
Milbury, P. G., & Silva, B. (1988). Problem-based learning, primary sources, and
information literacy, Multimedia Schools,5(4), 40-44.
Moore, J., & Barab, S. (2002). The inquiry learning form: A community of practice
approach to online professional development. TechTrends, 46(3), 44-51.
Owen, R. F., Hester, J. L, & Teale, W. H. (2002). Where do you want to go today?
Inquiry-based learning and technology integration. The Reading Teacher,55(7),
Prince, M. J., & Felder, R. M. (2006). Inductive teaching and learning methods:
Definitions, comparisons, and research bases. Journal of Engineering Education,
Reznich, C. B., & Werner, E. (2001). Integrating technology into PBL small groups in a
medical education setting. Paper presented at the Annual Meeting of the American LIBRES ISSN 1058-6768 Volume 18, Issue 1, March 2008 http://libres.curtin.edu.au/Educational Research Association (Seattle, WA, April 10-14, 2001). ERIC
Sage, S. (2000). A natural fit: Problem-based learning and technology standards.
Learning and Learning with Technology, 28(1), 6-12.
Schroeder E. E., & Zarinnia, E. A. (2001). Problem-based learning—Develop
information literacy through real problems. Knowledge Quest, 30(1), 34-35.
Snavely, L. (2004). Making problem-based learning work: Institutional challenges.
Libraries & the Academy, 4(4), 521-531.
Valadares, K. J. (2007). Active engagement in health services administration survey
courses through problem-based learning. The Journal of Health Administration
Woody, M., Albrecht, S., & Hines, T. (1999). Directed case studies in baccalaureate
nursing anatomy and physiology. Journal of Nursing Education, 38(8), 383-386.
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1940s TIME LINE • War escalated in Europe as Germany invaded Norway, Denmark, France, Belgium, and the Netherlands, and Russia took over Lithuania, Estonia, and Latvia. • U.S. passed military draft law. • Franklin D. Roosevelt defeated Wendell Willkie for FDR’s unprecedented third term. • U.S.S.R. and Japan signed neutrality pact. • Germany invaded U.S.S.R.; Stalin called for �
Targeting the Hepatitis C virus ion channel p7 for anti-viral therapy Stephen Griffin, Dean Clarke, Steve Evans, Alastair Smith, Joachim Jäger, Introduction Hepatitis C virus (HCV) currently infects over 3 % of the world population and is the major indicator for liver transplant surgery in the west. Acute infection is usually asymptomatic but leads to persistence in the majority