Das pharmakologische Profil von Sildenafil zeigt neben der PDE5-Inhibition auch eine geringe Aktivität an der PDE6 in der Retina. Dies erklärt visuelle Nebenwirkungen wie Farbsehstörungen, die gelegentlich auftreten. Die orale Bioverfügbarkeit beträgt etwa 40 %, mit einer hohen Bindung an Plasmaproteine. Das Verteilungsvolumen ist groß, sodass die Substanz rasch in verschiedene Gewebe gelangt. Die Metabolisierung erfolgt hepatisch und produziert einen aktiven Metaboliten, der die pharmakologische Wirkung ergänzt. Nebenwirkungen sind dosisabhängig und umfassen Kopfschmerzen, Hautrötung und Dyspepsie. Bei Vergleichen innerhalb der Wirkstoffklasse wird viagra original regelmäßig als Beispiel für eine Substanz mit schneller, aber kurzzeitiger Wirkung aufgeführt.
Microsoft word - tpn_the hormone puzzle.doc
The Hormone Puzzle Increase Risk of Breast Cancer Protection Strategy Excessive Strong Estrogens (Estradiol E1 Increase Estriol E3 (Weak estrogen) with: Decrease Estradiol E1 and Estrone E2
Improve liver detoxification & elimination Stall puberty Sleep in a dark room
Increased C4 and C16 Estrogens linked
Make more C2 Estrogen, Less C4 and C16; Inactivate C4 Estrogen with:
1. Promote formation of C2 estrogens:
2. Assist Liver Detoxification:
cysteine, taurine MSM betaine Vitamins B6, B12, B2, folic acid, choline Minerals – magnesium, selenium, zinc Calcium-D-glucarate Milk thistle, curcumin, ellagic acid
Increase Risk of Breast Cancer Protection Strategy
● Rebecca Lane, CNP, BA (Hons) 905-868-8506
3. Dietary – low fat diet, EPA (fish
oil), ground flax seeds, increased fibre, wheat bran, psyllium, probiotics, red clover, phytoestrogens - 8 to 10 servings of vegetables; 2 servings of fruit; 1 serving of complex carbohydrates (that means whole grains like brown rice, millet, quinoa, oats and whole wheat flours like spelt and kamut); 1 serving of protein (preferably nut and vegetable protein)
4. Normalize progesterone Increased Production of Strong Inhibit Aromataze with: Estrogens (Estradiol and Estrone) due to:
Ground flaxseed (moderate) Genistein (soy) (weak) Zinc
Decreased SHBG (Sex Hormone Binding Increase SHBG with:
Normalize cortisol, insulin, IGF-1, testosterone
Increased Number of Estrogen Decrease Number of Estrogen Receptors Receptors due to:
Xenoestrogens Hormone replacement therapy High Body Mass index
Xenoestrogens Attach to Estrogen Block Estrogen Receptors with: Receptors such as:
● Rebecca Lane, CNP, BA (Hons) 905-868-8506
Increase Risk of Breast Cancer Protection Strategy Decreased Progesterone due to: Increase Progesterone with:
Normalize thyroid, use zinc, seaweed, selenium to increase T3
High Prolactin due to: Normalize Prolactin with: Elevated Testosterone due to: Normalize Testosterone with: Increased Growth Hormone due to: Normalize Growth Hormone with:
● Rebecca Lane, CNP, BA (Hons) 905-868-8506
Increase Risk of Breast Cancer Protection Strategy Low Thyroid (Hypothyroid) Function Normalize Thyroid Function with: Increase Conversion of T4 to T3 with:
Tyrosine, cysteine, iodine Zinc, selenium, copper Vitamin B12 Flaxseed Oil
High Thyroid (Hyperthyroid) Function Normalize Thyroid Function with:
Magnesium, Vitamin B complex Avoid radiation
High Insulin Levels due to : Normalize Insulin Levels with:
Maintain ideal weight Chromium, magnesium, niacin Alpha lipoic acid Flax or fish oil
Increased IGF-1 due to: Lower IGF-1 with: Increase Risk of Breast Cancer Protection Strategy
● Rebecca Lane, CNP, BA (Hons) 905-868-8506
High Cortisol Levels due to: Normalize Cortisol Levels with:
Increased testosterone Decreased efficiency of thyroid hormone Decreased melatonin production
Decreased Melatonin due to: Increase Melatonin using:
in a.m. Exercise daily Normalize cortisol
Many thanks for this wonderful resource, adapted from:
The Complete Natural Medicine Guide to Breast Cancer,
● Rebecca Lane, CNP, BA (Hons) 905-868-8506
L' integrazione scolastica degli alunni stranieri Sintesi della normativa e cenni sulle strategie didattiche (a cura del dirigente tecnico Gian Antonio Lucca) L ' i n t e g r a z i o n e d e g l i a l u n n i s t r a n i e r i n e l l a s c u o l a Sintesi della normativa e cenni sulle strategie didattiche Sommario 1. Il diritto all' istruzione scolastica dei minori stranieri 2. Ricono