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Goto, G.H. Katayama, H. Tanigaki, Y. Fushiki, S. Nishizawa, Y and Nishizawa, Y. (2008) Methylcobalamin inhibits fibroblast growth factor-8 stimulated proliferation and induces apoptosis in Shionogi carcinoma cells. Int. J. Vitam. Nutr. Res., 78, 21-26 Kataoka, T. Tsukamoto, Y. Matsumura, M. Miyake, A. Kamiura, S. Ishiguro, S. and Nishizawa, Y. (2008) Expression of p21Cip1/Waf1 and p27Kip1 in small cell neuroendocrine carcinoma of the uterine cervix. Int. J. Surg. Pathol., 16, 11-15 Baba, M. Inoue, M. Itoh, K. Nishizawa, Y. (2008) Blocking CD147 induces cell death in cancer cells through impairment of glycolytic energy metabolism. Biochem. Kataoka, TR. Ioka, T. Tsukamoto, Y. Matsumura, M. Ishiguro, S. Nishizawa, Y. (2007) Nuclear expression of STAT5 in intraductal papillary mucinous neoplasms of the pancreas. Int. J. Surg. Pathol., 15, 277-281 Nishizawa, Y., Yamasaki, M., Katayama, H., Amakata, Y., Fushiki, S. and Nishizawa, Y. 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Yamamoto, T., Nishizawa, Y., Tsuji, M., Saitoh, Y., Funai, H., Hirai, T., Sugihara, A., Tsujimura, T., Nakata, Y., Ishiguro, S. and Terada, N. (1999) Expression of vascular endothelial growth factor in normal pituitary cells and pituitary adenomas producing adrenocorticotropic hormone. Endocrine Pathology, 10, 157-164. 17. Nishizawa, Y., Yamamoto, T., Tanigaki, Y., Kasugai, T., Mano, M., Ishiguro, S., Fushiki, S., Poirier, L.A. and Nishizawa, Y. (1999) Methylcobalamin decreases mRNA levels of androgen-induced growth factor in androgen-dependent Shionogi carcinoma 115 cells. Nutrition and Cancer, 35, 195-201. 18. Yamamoto, T., Terada, N., Seiyama, A., Nishizawa, Y., Akedo, H. and Kosaka, H. (1998) Increase in experimental pulmonary metastasis in mice by L-arginine under inhibition of nitric oxide production by NG-nitro-L-arginine methyl ester. Int. J. 19. Nishizawa, Y., Yamamoto, T., Terada, N., Fushiki, S., Matsumoto, K. and Nishizawa, Y. 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(1990) Effects of estrogen on cell proliferation and leukotriene formation in transformed mouse Leydig cells cultured under serum-free conditions. Cancer Res., 50, 31. Nishizawa, Y., Nishii, K., Kishimoto, S., Matsumoto, K. and Sato, B. (1990) Regulatory role of arachidonic acid-derived matabolites for proliferation of transformed murine Leydig cell in serum-free culture condition. Anticancer Res., 10, 32. Nishizawa, Y., Sato, B., Nishii, K., Kishimoto, S. and Matsumoto, K. (1989) Effect of androgen on proliferation of estrogen-responsive transformed mouse Leydig cells in serum-free culture. Cancer Res., 49, 1377-1382. 33. Nishizawa, Y., Sato, B., Miyashita, Y., Tsukada, S., Hirose, T., Kishimoto, S. and Matsumoto, K. (1988) Autocrine regulation of cell proliferation by estradiol and hydroxytamoxifen of transformed mouse Leydig cells in serum-free culture. 34. Nakamura, N., Nishizawa, Y., Noguchi, S., Uchida, N., Sato, B. and Matsumoto, K. (1987) Action mechanisms of physiological doses of androgen or pharmacological doses of estrogen in growth stimulation of Shionogi carcinoma 115 in mice. J. Steroid 35. Hiraoka, D., Nakamura, N., Nishizawa, Y., Uchida, N., Noguchi, S., Matsumoto, K. and Sato, B. (1987) Inhibitory and stimulatory effects of glucocorticoid on androgen-induced growth of murine Shionogi carcinoma 115 in vivo and in cell 36. Nishizawa, Y., Maeda, Y., Noma, K., Sato, B., Matsumoto, K. and Yamamura, Y. (1981) A modulator which converts activated estrogen receptor to a biologically inactive aggregated form. Endocrinology, 109, 1463-1472.


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HAI Treatments A Challenging Market Given the attention focused on hospital-acquired infections (HAIs), one would think there would be a thriving market for pharmaceutical products to combat this scourge. And there is a fairly large-sized market – over $8.06 billion earned in 2010 by companies selling pharmaceutical treatments. But it is a market that has seen declines for a variety of

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