Das pharmakologische Profil von Sildenafil zeigt neben der PDE5-Inhibition auch eine geringe Aktivität an der PDE6 in der Retina. Dies erklärt visuelle Nebenwirkungen wie Farbsehstörungen, die gelegentlich auftreten. Die orale Bioverfügbarkeit beträgt etwa 40 %, mit einer hohen Bindung an Plasmaproteine. Das Verteilungsvolumen ist groß, sodass die Substanz rasch in verschiedene Gewebe gelangt. Die Metabolisierung erfolgt hepatisch und produziert einen aktiven Metaboliten, der die pharmakologische Wirkung ergänzt. Nebenwirkungen sind dosisabhängig und umfassen Kopfschmerzen, Hautrötung und Dyspepsie. Bei Vergleichen innerhalb der Wirkstoffklasse wird viagra original regelmäßig als Beispiel für eine Substanz mit schneller, aber kurzzeitiger Wirkung aufgeführt.

Woodville.k12.ca.us

SECOND GRADE
STANDARDS BASED RUBRIC

PHYSICAL SCIENCE
Essential Standard:
THE MOTION OF OBJECTS CAN BE OBSERVED AND MEASURED.
First Trimester: Benchmarks
FAR BELOW/BELOW BASIC
PROFICIENT
ADVANCED
 Able to make predictions based on  Able to explain predictions based sequence of steps, events, and observations.  Unable to show understanding that  Demonstrates partial Below – Unable to show an
Basic - Inconsistently able to
Proficient – Able to understand and
Advanced –Independently able to
understanding and apply the
understand and apply the scientific
apply the scientific process, through
understand and apply the scientific
scientific process, through
process, through observation,
observation, predictions, collections, process, through observation,
observation, predictions, collections, predictions, collections, analyzing
analyzing and collecting data as
predictions, collections, analyzing
analyzing and collecting data as
and collecting data as appropriate.
appropriate.
and collecting data as appropriate.
appropriate.


EARTH SCIENCE
Essential Standard:
EARTH IS MADE OF MATERIALS THAT HAVE DISTINCT PROPERTIES AND PROVIDE RESOURCES FOR HUMAN ACTIVITIES.
Second Trimester: Benchmarks
FAR BELOW/BELOW BASIC
PROFICIENT
ADVANCED
minerals that were brought together during the rock cycle.  Unable to show understanding that  Demonstrates partial  Unable to show understanding that  Demonstrates partial  Unable to show understanding that  Shows partial understanding that past history of earth by studying fossils. Below – Unable to show an
Basic - Inconsistently able to
Proficient – Able to understand and
Advanced –Independently able to
understanding and apply the
understand and apply the scientific
apply the scientific process, through
understand and apply the scientific
scientific process, through
process, through observation,
observation, predictions, collections, process, through observation,
observation, predictions, collections, predictions, collections, analyzing
analyzing and collecting data as
predictions, collections, analyzing
analyzing and collecting data as
and collecting data as appropriate.
appropriate.
and collecting data as appropriate.
appropriate.

LIFE SCIENCE
Essential Standard:
PLANTS AND ANIMALS HAVE PREDICTABLE LIFE CYCLES.
Third Trimester: Benchmarks
FAR BELOW/BELOW BASIC
PROFICIENT
ADVANCED
characteristics, inherited from their parents.  Demonstrate understanding of life  Independently investigate and are different for different animals (e.g. butterflies, mice, frogs). Below – Unable to show an
Basic - Inconsistently able to
Proficient – Able to understand and
Advanced –Independently able to
understanding and apply the
understand and apply the scientific
apply the scientific process, through understand and apply the scientific
scientific process, through
process, through observation,
observation, predictions,
process, through observation,
observation, predictions,
predictions, collections, analyzing
collections, analyzing and collecting predictions, collections, analyzing
collections, analyzing and collecting and collecting data as appropriate.
data as appropriate.
and collecting data as appropriate.
data as appropriate.

T:\website\WORD\RUBRICS\SCIENCE, K-6\2nd science.doc

Source: http://www.woodville.k12.ca.us/pdf/rubric/2-s.pdf