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Form 34qr asperger-february2007.pub

Note: The data below are based on cases identified as “Asperger Syndrome” N=1,199
PARENT RATINGS OF BEHAVIORAL EFFECTS OF BIOMEDICAL INTERVENTIONS
Autism Research Institute ● 4182 Adams Avenue ● San Diego, CA 92116
The parents of autistic children represent a vast and important reservoir of information on the benefits—and adverse effects— of the large variety of drugs and other interventions that have been tried with their children. Since 1967 the Autism Research Institute has been collecting parent ratings of the usefulness of the many interventions tried on their autistic children. The following data have been collected from 1,199 parents who have completed our questionnaires designed to collect such information. For the purposes of the present table, the parents responses on a six-point scale have been combined into three categories: “made worse” (ratings 1 and 2), “no effect” (ratings 3 and 4), and “made better” (ratings 5 and 6). The “Better:Worse” column gives the number of children who “Got Better” for each one who “Got Worse.” Parent Ratings
Parent Ratings
Parent Ratings
Got No Got Better: No. of
Got No Got Better: No. of
Got No Got Better: No. of
WorseA Effect Better Worse CasesB DRUGS WorseA Effect Better Worse CasesB
DRUGS WorseA Effect Better Worse CasesB
24% 38% 1.0:1
Desipramine 25% 50% 25% 1.0:1 12
Phenobarb.D
Amphetamine 30%
28% 43% 1.4:1
DilantinD
Behavior
Anafranil
40% 38% 1.8:1
Behavior
Seizures
Antibiotics
45% 20% 0.6:1
Seizures
Prolixin
AntifungalsC
Felbatol
1.4:1 157
Diflucan
35% 59% 9.7:1
Fenfluramine 0% 86% 14%
Risperidal
2.7:1 161
Nystatin
38% 53% 6.8:1
1.0:1 374
35% 30% 0.9:1
Secretin
Benadryl
50% 20% 0.7:1
Intravenous 6% 44%
Beta Blocker 11%
54% 36% 3.3:1
KlonapinD
Transderm. 0% 43%
54% 29% 1.6:1
Behavior
Stelazine
Seizures
Steroids
55% 15% 0.5:1
TegretolD
Clonidine
39% 39% 1.7:1
Behavior
Clozapine
50% 21% 0.7:1
Mellaril
Seizures
Cogentin
50% 20% 0.7:1
MysolineD
Thorazine
54% 14% 0.4:1
Behavior
Tofranil
Seizures
DepakeneD
Naltrexone
ZarontinD
Behavior
38% 35% 1.3:1
Behavior
Seizures
61% 30% 3.5:1
Phenergan
Seizures
0% 100% 0%
BIOMEDICAL/
Parent Ratings
BIOMEDICAL/
Parent Ratings
NON-DRUG/
Got No Got Better: No. of
NON-DRUG/
Got No Got Better: No. of
SUPPLEMENTS WorseA Effect Better Worse CasesB
SUPPLEMENTS
WorseA Effect Better Worse CasesB
CalciumE
Vitamin A
61% 33% 6.2:1
Cod Liver Oil
Vitamin B3
44% 50% 9.0:1
Cod Liver Oil with
Vit. B6/Mag.
44% 51% 10:1
Bethanecol
Vitamin B12
31% 61% 7.7:1
Colostrum
Vitamin C
50% 48% 17:1
Detox. (Chelation)C
38% 58% 14:1
Digestive Enzymes
SPECIAL DIETS
Fatty Acids
Candida Diet
40% 59% 37:1
Folic Acid
Feingold Diet
Food Allergy Trtmnt 3% 35%
Gluten- /Casein-
28% 70% 35:1
Hyperbaric Oxygen
Free Diet
53% 45% 32:1
Magnesium
Chocolate
Melatonin
Removed Eggs
63% 34% 14:1
MT Promoter
Removed Milk
45% 54% 33:1
Products/Dairy
P5P (Vit. B6)
Removed Sugar
50% 46% 9.8:1
Removed Wheat
45% 54% 56:1
Rotation Diet
40% 58% 35:1
St. Johns Wort
Specific Carbo-
37% 59% 16:1
hydrate Diet
Transfer Factor
A. “Worse” refers only to worse behavior. Drugs, but not nutrients, typically also cause physical problems if used long-term. B. No. of cases is cumulative over several decades, so does not reflect current usage levels (e.g., Haldol is now seldom used). C. Antifungal drugs and chelation are used selectively, where evidence indicates they are needed. D. Seizure drugs: top line behavior effects, bottom line effects on seizures. E. Calcium effects are not due to dairy-free diet; statistics are similar for milk drinkers and non-milk drinkers.

Source: http://www.vsan.org/pdf/ARI_TreatmentRatings_AS_Feb2007.pdf

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