Microsoft word - nsaids.doc
Veterinary Surgical Services
A WARNING CONCERNING ARTHRITIS MEDICATION
(etodolac) tablet, Rimadyl
(carprofen) caplet, chewable tablet or injection, Deramaxx
(meloxicam) oral drop or injection, Zubrin
(tepoxalin) disintegrating tablet, Previcox
tablet and Novox
(generic carprofen) caplet all belong to a class of drugs called non-steroid anti-inflammatory drugs. The
action of these drugs is similar to aspirin, which is also a NSAID. It should be given under the advice of a veterinarian
since overdoses can cause symptoms of bleeding and stomach ulcers.
Aspirin can inhibit inflammatory substances called prostaglandins (PGEs), which cause Pain, inflammation, and fever.
These drugs are safer than aspirin because they are more selective for the harmful prostaglandins (COX 2 PGEs) and
spare certain prostaglandins (COX 1 PGEs) which are essential to protect the G.I. tract, kidneys, and other organs. There is risk of liver failure with all NSAIDs.
Liver necrosis in Labrador Retrievers caused by Rimadyl has been
reported in large numbers. The manufacturer of Rimadyl alleges these reactions are attributed to the fact that Labs are
the most common breed, and Rimadyl was the first and most commonly prescribed NSAID. All NSAIDs have the potential
to cause liver failure and other side effects. Blood tests before administration of NSAIDs can not predict this liver
The risk of this reaction is small. (1:10,000 with Rimadyl) NSAIDs are relatively new to veterinary medicine.
Veterinarians have little clinical experience with these drugs.
Although every manufacturer has data that alleges their drug is safer than the others, no creditable non-manufacturer
sponsored data exists
which accurately compares these drugs.
Do you ask your Vet for a written warning about side effects, and read this warning.
Ask to see the manufacturer’s
package insert. Do test your pet for kidney problems
before starting NSAIDs. This is especially important in older pets, which are prone
to kidney failure. A urinalysis and a series of blood tests called an “NSAID Profile” are essential. The NSAID Profile
checks the BUN, ALT, urine specific gravity, and Complete Blood Count. Do monitor kidney and liver function
IF YOUR PET IS ON THESE DRUGS FOR A PROLONGED PERIOD OF TIME.
An NSAID Profile is mandatory every year, and strongly recommended every six months. Do give Pepsid AC® 10mg tablet
every time you administer an NSAID in order to prevent duodenal ulcers and diarrhea,
which are common side effects of all NSAIDs. Unfortunately, this antacid will not prevent gastric ulcers. Do give Polysulfated glucosamines, also called PSGAGs (Chondroprotec, Chondroflex, or Cosequin)
prolonged use of NSAIDs for arthritis and degenerative joint disease. NSAIDs relieve pain, but unfortunately over a long
period of time, NSAIDs can contribute to cartilage degeneration. PSGAGs help cartilage to heal. NSAIDs can cause
ulceration of the gasrto-intestinal tract. PSGAGs are part of the protectant lining of the gastro-intestinal tract. NSAIDs are
tolerated with PSGAGs. PSGAGs also protect the kidney.
Do stop the medication at the first signs of gastric upset,
nausea, lack of appetite, vomiting, or diarrhea. Advise your
boarding kennel of this important fact.
Do not mix NSAIDs. Do not give NSAIDs with steroids
like dexamethasone, prednisone, Vetalog or Depomedrol.
Gastro-intestinal ulceration and bleeding can result. A 3-5 day withdrawal period is necessary if you switch from one
NSAID to another. A 14 day withdrawal period is necessary if switching to an NSAID from a steroid such as
Tramadol can be used for pain during the withdrawal period. Do not give NSAIDs in patients with unknown impaired gastro-intestinal, kidney, cardiovascular, or coagulation
functions. If liver enzymes are evaluated, use only at a lowered dose and with liver treatment medication (i.e.
SAM-E). In these cases, Tramadol can be used as a substitute pain reliever.
Do not give NSAIDs with Enalapril
or other ACE inhibitors, Lasix
, or with nephrotoxic drugs like aminoglycoside
antibiotics, or psycotropic drugs such as Prozac or Clomicalm. Do not give NSAIDs in dogs with Cushing’s disease, Heartworm disease, Immune Mediated Hemolytic Anemia
other diseases where the patient is predisposed to blood clots called thromboembolisms.
Etodolac has been shown to cause Kerato conjunctivitis Sicca, also known as dry eye. Watch for signs of
sqinting or a white discharge coming from the eyes. If these symptoms occur, stop the drug immediately and call
A FINAL NOTE:
Relief from pain by NSAIDs is an individual response. If your pet does not get adequate relief from pain and return to
normal function with one NSAID, it is worth trying a different NSAID. Never increase the dose on your own or give
another drug for pain without first discussing with your veterinarians.
Reactions to NSAIDs are comparable. If your
pet has an adverse reaction to one NSAID, another NSAID should not
be used. Another class of pain reliever drug
(Tramadol) should be used.
March 2009 WARNING! EXCLUDING KNOWN HAZARDS FROM FDA- A PPROVED LABELING CONTRAINDICATED BY STATE COMMON LAW TORT SUITS AND THE SUPREME COURT The Supreme Court of the United States dealt a surprising blow to both the pharmaceutical manufacturing industry and the FDA when it issued its opinion earlier Chicago, IL 60661-2511 phone: (312) 715-5000 this month, in Wyeth v. L
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