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Microsoft word - tim tucker cv aug 2008.doc
ABRIDGED CURRICULUM VITAE
Tucker, Timothy Johan Paul
UNIVERSITY DEGREES AND PROFESSIONAL QUALIFICATIONS
Fellow of the College of Pathologists of South Africa
CURRENT PROFESSIONAL APPOINTMENTS
1: Head of Private Strategy Consultancy –“SEAD - Strategic Evaluation,
Advisory and Development Consultancy (Pty) Ltd”
Head of a consultancy specializing in health strategy development (predominantly
HIV programs and biotechnology R&D) for national and international organizations,
with turn-over of >$1 million per year. Tim has been appointed as an advisor in the
last three years to many agencies, including:
organizational change & HIV programmatic strategies
HIV vaccine strategies relevant to adolescents and African clinical trial sites
the US Centres for Disease Control and Prevention
PEPFAR grant for program evaluation and strategy development
Guidance document for the development of National Laboratory Strategic Plans
Advisor for development of an appropriate HIV policy and implementation
Independent third party review of HIV program
Advisor to bank for the development of appropriate HIV policies for companies where
Novel Hib and Pentavalent vaccine product development strategies, regulatory
submission and trial design (out-sourced medical department)
strategy for new GMP pre-clinical animal facility for vaccines
external evaluation of EC-funded HIV program sites in Tanzania
assessment of FP7 project applications on HIV vaccines
global consultation and development of five year strategic plan
development of strategy documentation relating to National AIDS Vaccine Plans for
the Council for Scientific and Industrial Research
biotech and product development strategies
strategy motivating for new national PPP for malaria research
5 year membership of WHO Vaccine Advisory Committee
audit of biotechnology products in development in SA
development of a novel laboratory prognostic marker for HIV
organizational change & fundraising strategies
the Circulatory Diseases Research Fund
organizational change & HIV programmatic strategies
2: University of Cape Town:
Honorary senior lecturer, Clinical Virology.
Teach honours students within the Institute of Infectious Diseases and
Mentor Clinical Virology trainee specialists and junior specialists.
3: World Health Organization
Advisor for the Vaccine Advisory Committee of the WHO.
Director of the South African AIDS Vaccine Initiative (SAAVI) – 2001-4
Tim Tucker, as SAAVI Director, was the senior person responsible for the
management and strategic direction of all aspects of the $8-10 million per year
initiative which is conducted at numerous consortium partners (>30) within SA and
abroad. This initiative is mandated by the South African Cabinet and is a public
private partnership with global influence. The incumbent is responsible for
fundraising nationally and internationally to support the scientific, clinical and
community directions of SAAVI. This job is associated with senior national and
international responsibilities. The SAAVI Director is required to manage the
business of this large consortium, including the contractual and intellectual property
The seniority and professional influence of this position is substantial, with regular
contact with senior Government officials, including Cabinet Ministers, Directors-
General of various departments, and others. Tim had a personal invitation from Mr.
Nelson Mandela to brief him and keep him updated on AIDS vaccine clinical trial
progress. Tim Tucker was invited to a World Economic Forum in Durban to talk
about the need for additional support for AIDS vaccines globally. Tim has played an
advisory role at many international organizations.
Deputy Chairperson of the African AIDS Vaccine Program (AAVP)
Tim Tucker was deputy Chairperson of the African AIDS Vaccine Program and
worked to increase the stature, magnitude and work of the AAVP. The AAVP is a
network of HIV vaccine stakeholders on the continent. The position requires the
person to build capacity amongst others in the field, and advocate for the African HIV
vaccine agenda. Tim remains an active member of this African network.
Groote Schuur Hospital. Department of Clinical Virology:
Tim worked in the Clinical Virology Department of Groote Schuur Hospital/University
of Cape Town, where he led a hepatitis research group in the faculty; as well as
working as a clinical virologist in the routine laboratory of the hospital. This is where
Tim received his specialist training in Clinical Virology, and completed his PhD in
Senior Clinical Research Fellow:
Tim was a senior Clinical Research Fellow MRC/UCT Liver Research Centre, where
he was registered for his Ph.D. The research work was supported by multiple
scholarships from the Medical Research Council and the University of Cape Town.
During this time, Tim was responsible for:
The Ph.D. work which involved field epidemiology, routine serology, molecular
diagnostics, development of novel molecular techniques, and novel molecular
biology investigations (see Ph.D. title below).
Establishment and management of the Liver Research Centre Clinical Trials
Group. This group performed multiple phase I, phase II and phase III clinical
trials, specializing in novel treatments for hepatitis B and C, as well as
cirrhosis. (Please find a list below of a selection of the clinical trials where Tim
performed a substantial leadership role).
Weekly sessions working in the specialist Liver Clinic of the Groote Schuur
Regular sessions working in the liver transplant wards of the Groote Schuur
Hospital and the Red Cross Children’s Hospital.
Groote Schuur Hospital:
(General medicine, oncology, gynaecology and
Ph.D. THESIS: 1999
Epidemiology, molecular characterisation and tissue
tropism of the hepatitis G virus / GBV-C
INVITATIONS TO GIVE LECTURES AT SOUTH AFRICAN AND FOREIGN
INSTITUTIONS, AND CONFERENCE PRESENTATIONS
Tim Tucker has consistently been invited to speak throughout his career in manyinstitutions in South Africa and abroad. This has been a combination ofenvironments, including conferences, private companies, academic groups,governmental, NGO’s, national and international funding organizations, WorldEconomic Forum, and others. He has given many academic, policy-based andstrategy plenary talks at various conferences. The list below is a selection of theinvited lectures that Tim has given in recent years. The nature of many of the talksreflects the major role that Tim played, as a public advocate for AIDS vaccines in SAand globally.
adolescents: Appropriate vectorsand strategies
Technology ParliamentaryPortfolio Committee
Opportunities for HIV vaccine trialcollaborations in southern Africa
industry with the SA AIDS VaccineInitiative
proposed corporate structure fornovel vaccines generated in plants,after development at the Universityof Cape Town
RECENT HIV VACCINE AND OTHER CONFERENCES/MEETINGS
WHO Scientific Meeting to review recent AIDS vaccine trials of
Standardization of HIV neutralization assays for use in vaccine
Rwandan Department of Health – development of a national HIV
African AIDS Vaccine Program Steering Committee meeting
Review meeting of EU-funded HIV vaccine programs in
African AIDS Vaccine Program Steering Committee meeting
African AIDS Vaccine Program consultation on the inclusion of
Thinking and planning strategically – Wits Business School
Global HIV Vaccine Enterprise consultation
WHO / AAVP consultation on adolescent inclusion in HIV
Initiative of Public Private Partnerships in Health (IPPPH)
Federation of African Immunology Societies Conference
Technology Top 100 Award Ceremony – (SAAVI finalist)
WHO consultation on the release of Phase III HIV vaccine
African AIDS Vaccine Program (official launch)
WHO/AAVP meeting: Challenges when Initiating Trials in
National Institutes of Health, Vaccine Research Center
African Association for the study of Liver Diseases
Joint Conf of Royal College of Surgeons of England and SA
American Association for the Study of Liver Diseases
African Health Sciences Conference: 15th Epidemiological
International Association for the Study of Liver Diseases
First International Conference on the Hepatitis E Virus
European Association for the Study of the Liver
International Congress on the Impact of Viral Diseases in the
Conference for the Development of a National Strategy for the
Prevention and Management of Transfusion-associatedHepatitis
International Association for the Study of Liver Diseases
South African Infection Control Society Conference
South African Transplantation and Immunology Conference
Tim has been a reviewer for medical journals, where he reviews HIV-related (andother) papers. He is a member of the honorary editorial board of Risk Managementand Healthcare Policy Journal.
Refereed Journals: (in reverse order)
29: African AIDS Vaccine Programme Strategic Plan for a Co-ordinated andCollaborative Vaccine Development Effort on the Continent. P. Kaleebu, A. Abimiku,S. El-Halabi, S. Koulla-Shiro, S. Mboup, J. Nkengasong, C. Toure-Kane, T. Tucker,D. Wassenaar, C. Williamson, D. Wolday. In print 2008: PLoS Medicine.
28: Tucker TJ, Makgoba MW. Public-Private Partnerships and ScientificImperialism. Science 23 May 2008 Vol. 320. no. 5879, pp. 1016–1017.
27: Inclusion of adolescents in HIV vaccine trials. Authors: WHO/UNAIDS/AAVPInternational Expert Group. T.J. Tucker a primary contributor and author of thispaper. J Acquir Immune Defic Syndr. 2007 Nov AIDS 2007.
26: HB Jaspan, CK Cunningham, TJ Tucker, PF Wright, SG Self, R L Sheets, MAAllen, AS Rogers, L-G Bekker, CM Wilson, A Duerr, JN Wasserheit. HIV VaccineTrials Network Adolescent Working Group Position Paper: Routine inclusion ofadolescents in prophylactic HIV vaccine development. Journal of AIDSEpidemiology; Nov 2007.
25: Smit J, Middelkoop K, Myer L, Lindegger G, Swartz L, Seedat S, Tucker TJ,Wood R, Bekker L-G, Stein DJ. Socio-behaviour challenges to phase III HIV vaccinetrials in Sub-Saharan Africa. Afr Health Sci. 2005 Sep ;5 (3):198-206 16245989
24: Mohlala B, Tucker TJ, Besser M, Williamson C, Yeats J, Smit L, Anthony J,Puren A. Investigation of HIV in amniotic fluid of HIV infected pregnant women atterm. Journal of Infectious Diseases: 2005 Aug 192: 488-491.
23: Tucker TJ, Mazithulela G. Development of an AIDS vaccine: perspective fromthe South African AIDS Vaccine Initiative. British Medical Journal. 2004 Aug2;329(7463):454-6.
21: Mangisa NP, Smuts HE, Kramvis A, Linley CW, Skelton M, Tucker TJ, De La MHall P, Kahn D, Jilbert AR, Kew MC. Molecular characterization of duck hepatitis Bvirus isolates from South African ducks. Virus Genes. 2004 Mar;28(2):179-86.
20: Smuts HE, Tucker TJ. High prevalence of TT virus in a rural community ofSouth Africa. S Afr Med J. 2003 Apr;93(4):276-7.
19: Interviewed by Pam Das. Tim Tucker--Director of the South African AIDSVaccine Initiative. Lancet Infect Dis. 2003 Mar;3(3):173-5.
18: ds an HIV vaccine in South Africa. Continuing MedicalEducation
17: M.W. Makgoba, N. Solomon, T.J. Tucker. Science, Medicine and the Future:the search for an HIV vaccine. British Medical Journal
. January 2002; 211-213.
16: T.J. Tucker, J. Yeats. Laboratory Monitoring of HIV is Next Challenge forDeveloping World After Antiretroviral Drugs.
September 2001; 89:286-
15: [Invited review
] T.J. Tucker, H.E.M. Smuts. Review of the Epidemiology,Molecular Charactof the Hepatitis G Virus / GBV-C. Journal ofClinical Laboratory
14: T.J. Tucker, H.E.M. Smuts. GBV-C/HGV Genotypes: Proposed Nomenclaturefor Genotypes 1-5. Journal of Medical Virology
2000 Sep; 62:82-83.
13: Trepo C, Jezek P, Atkinson G, Boon R, Young C et al. Famciclovir in chronichepatitis B: results of a dose-finding study. J Hepatol. 2000 Jun;32(6):1011-8.
12: T.J. Tucker, H.E.M. Smuts, C. Eedes, D. Knobel, P. Eickhaus, S.C. Robson,R.E. Kirsch. Evidence that GBV-C/Hepatitis G Virus is Primarily a LymphotropicVirus. Journal of Medical Virology
2000 May; 61(1):52-58.
11: P-W. Lee, M-S. Park, G.A. Keen, Z Noveljik, T.J. Tucker, E. Van der Ryst, J.I.
Viljoen, A-M Pretorious, M. Oelofsen. Seroepidemiological evidence for thepresence of Hantaviruses in South Africa. The Journal of the Korean Society ofVirology
1999. Vol 29(1).
10: T.J. Tucker, H. Smuts, P. Eickhaus, S.C. Robson, R.E. Kirsch. MolecularCharacterization of the 5’ Non-Coding Region of South African GBV-C/HGV Isolates:Major Deletion and Evidence for a Fourth Genotype. Journal of Medical Virology
9: T.J. Tucker, H.E.M. Smuts, P Eickhaus, S.C. Robson, R.E. Kirsch, C. Swanepoel.
The Hepatitis G Virus / GBV-C is Associated with Glomerulonephritis in SA. LetterSAMJ
March 1998; 88:286-7.
8: Tucker TJ, Louw SJ, Robson SC, Isaacs S, Kirsch RE. High prevalence ofHepatitis G virus (HGV) infection in a rural South African population. Journal ofMedical Virology
7: Muller FO, Terblanche J, Schall R, van Zyl Smit R, Tucker T, Marais K,Groenewoud G, Porchet HC, Weiner M, Hawarden D. Pharmokinetics of triptorelinafter intravenous bolus administration in healthy males and in males with renal orhepatic insufficiency. British Journal of Pharmacology 1997;44:335-41.
6: Tucker T, Kirsch RE, Louw SJ, Isaacs S, Kannemeyer J, Robson SC.
Epidemiology of Hepatitis E in South Africa. Journal of Tropical Gastroenterology(special edition for conference proceedings)
5: Tucker TJ, Keen GA, Yates J, Hardie DR. Lack of hepatitis Delta in the WesternCape, South Africa. Letter SAMJ
4: T.J. Tucker, M. Voigt, A. Bird, S. Robson, B. Gibbs, J. Kannemeyer, M. Galloway,R. E. Kirsch H. Smuts. Hepatitis C Virus Infection in Blood Donors from the WesternCape, South Africa: Comparison of Screening Tests and PCR: SAMJ May1997;87:603-5.
3: Tucker T, Kirsch RE, Louw SJ, Isaacs S, Kannemeyer J, Robson SC. Hepatitis Ein South Africa: Evidence for Sporadic Spread and Increased Seroprevalence inRural Areas. Journal of Medical Virology
October 1996; 50: 117-120.
2: Voigt MD, Bird A, Kirsch RE, Kew M, et al. National strategy for the preventionand management of transfusion-associated hepatitis. SAMJ
1: Tucker TJ, Kirsch RE. Hepatitis E. SAMJ
August 1994; 84:548-549.
CLINICAL TRIAL EXPERIENCE
1) Tim has performed multiple clinical trials, and has experience with phase I, II andIII studies. He initiated and directed the MRC/UCT Liver Research Centre clinicaltrials unit, which ran the trials as well as developed capacity within the departmentand broader faculty. The studies were often critical path studies for early stageproduct development. A selection of these studies are shown below where Timplayed a substantial role.
2) In addition, while SAAVI Director, Tim led the national effort to take two “DNA-based HIV vaccines” and one “MVA-based HIV vaccine” through development,manufacturing and preclinical testing in preparation for human clinical trials withthese novel products within SA and the USA. This included submission of regulatorydocuments to the FDA and pre-submission discussions with the South AfricanMedicines Control Council. This process will make SAAVI the first body in Africa totake a novel biologics product from concept to human trials.
A multi-centre randomised, double-blind, placebo controlled study to asses the safety and efficacyof oral Famciclovir for the treatment of chronic hepatitis B.
Tolerance and pharmacokinetics of multiple oral doses of HOE077 tablets in patients with livercirrhosis.
Tolerance and pharmacokinetics of a single oral dose of 160mg HOE277 tablets in patients withliver cirrhosis.
Tolerance and pharmacokinetics of multiple oral doses of HOE277 tablets in patients with livercirrhosis.
A phase 2, multi-centre, open-labelled study to determine the efficacy of Hep B-3 in the treatmentof patients chronically infected with the hepatitis B virus.
A phase 2, multi-centre, double-blinded, placebo-controlled study to determine the efficacy of HepB-3 in the treatment of patients chronically infected with the hepatitis B virus in the low replicativestate.
A rising dose tolerance study in healthy human subjects, examining increasing doses ofchlorproguanil with a constant dose of dapsone.
Pharmacokinetic assessment of Tryptorelin after single intravenous bolus administration inhealthy volunteers and patients with renal and liver insufficiency.
15. Cutter NC, Scott DD, Johnson JC, Whiteneck30. Jarrett L, Nandi P, Thompson AJ. Managing se-G. Gabapentin effect on spasticity in multiplevere lower limb spasticity in multiple sclerosis:1. Abrams P. Evidence for the efficacy and safetysclerosis: a placebo-controlled, randomized does intrathecal phenol have a role? J Neurolof tolterodine in the treatment of overactivetrial. Arch Phys Me
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