Das pharmakologische Profil von Sildenafil zeigt neben der PDE5-Inhibition auch eine geringe Aktivität an der PDE6 in der Retina. Dies erklärt visuelle Nebenwirkungen wie Farbsehstörungen, die gelegentlich auftreten. Die orale Bioverfügbarkeit beträgt etwa 40 %, mit einer hohen Bindung an Plasmaproteine. Das Verteilungsvolumen ist groß, sodass die Substanz rasch in verschiedene Gewebe gelangt. Die Metabolisierung erfolgt hepatisch und produziert einen aktiven Metaboliten, der die pharmakologische Wirkung ergänzt. Nebenwirkungen sind dosisabhängig und umfassen Kopfschmerzen, Hautrötung und Dyspepsie. Bei Vergleichen innerhalb der Wirkstoffklasse wird viagra original regelmäßig als Beispiel für eine Substanz mit schneller, aber kurzzeitiger Wirkung aufgeführt.

Dr ann low - publications

Dr Ann Low - Publications
Behrens, R. H., Taylor, R. B., Low, A. S., Warburton, B. & Pryce, D. (1994). Traveller's diarrhoea:
a controlled study of its effect on chloroquine and proguanil absorption. Transactions of the Royal
Society of Tropical Medicine and Hygiene 88, 86-88.
Behrens, R. H., Taylor, R. B., Pryce, D. I. & Low, A. S. (1998). Chemoprophylaxis compliance in
travellers with malaria. Journal of Travel Medicine 5, 92-94.
Cunningham, S. M. C., MIhara, S. & Lees, G. M. (1994). Presynaptic inhibition by neuropeptide Y
of slow inhibitory synaptic transmission in submucous neurones of guinea-pig caecum. Experimental
Physiology 79, 261-264.
Cunningham, S. M. C., Mihara, S. & Lees, G. M. (1994). Y2-receptor mediated inhibition of slow,
inhibitory synaptic potential in submucous neurones of guinea-pig caecum. British Journal
Pharmacology 113, 883-888.
Law, S. P., Melvin, M. A. L. & Lamb, A. J. (2001). Visualisation of the establishment of a
heterotrophic biofilm within the schmutzdecke of a slow sand filter using scanning electron
microscopy. Biofilm 6.
Low, A. S. & Taylor, R. B. (1995). Analysis of common opiates and heroin metabolites in urine by
HPLC. Journal of Chromatography B 663, 225-233.
Low, A. S., Taylor, R. B. & Gould, I. M. (1989). Determination of clavulanic acid by a sensitive
HPLC method. Journal of Antimicrobial Chemotherapy 24, 83-86.
Low, A. S. & Wangboonskul, J. (1999). An HPLC assay for the determination of ketoconazole in
common pharmaceutical preparations. The Analyst 124, 1589-1593.
Melvin, M. A. L. & Keir, H. M. (1978). Polyamine metabolism in BHK-21/C13 cells: loss of
spermidine from cells following transfer to serum-depleted medium. experimental Cell Research 111,
231-236.
Robertson, R. F., Al-Haj, A. J., Clarke, A., Peck, L. S. & Taylor, E. W. (2001). The effects of
temperature on metabolic rate and protein synthesis following a meal in the isopod Glyponotus
antarcticus eights (1852). Polar Biology 24, 677-686.
Rouzaud, G., Duncan, A. J., Rabot, S., Ratcliffe, B., Durao, J., Garrido, S. & Young, S. (2000).
Factors influencing the release of cancer-protective isothiocyanates in the digestive tract of rats
following consumption of glucosinolate-rich brassica vegetables. In Dietary Anticarcinogens and
Antimutagens: Chemical and Biological Aspects, pp. 92-95. Edited by I. T. Johnson & G. R. Fenwick.
Cambridge: Royal Society of Chemistry.
Rouzaud, G., Duncan, A. J., Young, S. & Ratcliffe, B. (2001). Bioavailability of cancer-protective
isothiocyanates following ingestion of cooked cabbage, coleslaw and mustard by healthy human
subjects. Proceedings of the Nutrition Society 60, 34A.
Taylor, R. B., Low, A. S. & Reid, R. G. (1996). Determination of opiates in urine by CE. Journal of
Chromatography B 675, 213-223.
Taylor, R. B., Low, A. S. & Reid, R. G. (2000). Separation of selected opiates by HPLC and CE. In
Encyclopedia of Separation Science, pp. 3010-3017: Academic Press Limited.
Taylor, R. B., Moody, R. R., Ochekpe, N. A., Low, A. S. & Harper, M. I. A. (1990). A chemical
stability study of proguanil hydrochloride. International Journal of Pharmaceutics 60, 185-190.
Taylor, R. B., Reid, R. G. & Low, A. S. (2001). Analysis of proguanil and its metabolites by
application of the sweeping technique in micellar electrokinetic chromatography. Journal of
Chromatography A 916, 201-206.
Taylor, R. B., Richards, R. M. E., Low, A. S. & Hardie, L. (1994). Chemical stability of polymixin
B in aqueous solution. International Journal of Pharmaceutics 102, 201-206.
Taylor, R. B., Shakoor, O., Behrens, R. H., Everard, M., Low, A. S., Wangboonskul, J., Reid, R.
G. & Kolawole, J. A. (2001). Pharmacopeial quality of drugs supplied by Nigerian pharmacies. The
Lancet 357, 1933-1936.
Taylor, R. B., Smith, G. M. & Low, A. S. (1985). Ion-pairing chromatography of leukotrienes, LTB4,
LTC4 and LTD4. Journal of Pharmacy and Pharmacology 37, 131-136.
Yordanov, R. V., Lamb, A. J., Melvin, M. A. L. & Littlejohn, J. W. (1996). Biomass characteristics
of slow sand filters receiving ozonated water. In Advances in Slow Sand and Alternative Biological
FiltraTION, pp. 107-118. Edited by N. Graham & R. Collins: John Wiley and Sons.
Yordanov, R. V., Lamb, A. L. & Melvin, M. A. L. (1994). Studies on the biomass of slow sand
filters. In Scottish Microbiology Club Symposium. Aberdeen.
Yordanov, R. V., Lamb, A. L., Melvin, M. A. L. & Littlejohn, J. W. (1996). Biomass characteristics
of slow sand filters receiving ozonated water. In Advances in Slow Sand and Alternative Biological
Filtration, pp. 107-118. Edited by N. Graham & R. Collins: John Wiley and Sons.
Yordanov, R. V., Littlejohn, J. W., Lamb, A. J. & Melvin, M. A. L. (1995). Biodegradable organic
carbon (BDOC) removal from ozonated water during slow sand filtration. Proceedings of the Society of
General Microbiology Meeting, Aberdeen , 91.

Source: https://www.rgu.ac.uk/files/Dr%20Ann%20Low.pdf