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Microsoft word - curry patrick personal.cv.doc

Patrick T. Curry, Ph.D.
Professional Experience
Illinois Institute of Technology, Research Institute
Senior Scientist (Section Head, Genetic Toxicology, Microbiology and Molecular Biology Division) Manage a fully GLP compliant genetic toxicology laboratory capable of conducting the complete genetic toxicology test battery (Ames assay, Mouse Lymphoma assay, Structural Chromosome Aberration assay and the in vivo Rodent Micronucleus assay) in addition to several GLP compliant cytotoxicity assays and numerous non-GLP genetic toxicology screening assays. Responsibilities: Study Director for all cytogenetics studies (in vivo and in vitro), supervise 8 laboratory technicians, write/review SOPs, protocols, reports, implement all associated study processes from study initiation to report distribution/review. Food and Drug Administration OFAS/CFSAN
Review Scientist (Office of Food Additive Safety – OFAS) Review/Assess Safety Narratives for food contact substances as they are submitted to the Agency. Contribute to the design of Guidance Documents within the Agency. Act as a resource person in genetic toxicology within OFAS. DuPont Pharmaceuticals Company/Bristol-Myers Squibb Company 10-99 to 12-01
Senior Research Scientist
Constructed a fully GLP compliant cytogenetics laboratory capable of conducting in vitro chromosome aberration studies in CHO cells and Human lymphocytes, and in vitro micronucleus assays. All supporting staff, equipment, SOPs, documentation templates, data analysis methods and study conduct processes were in place in less than one year. Responsibilities: Study Director for all cytogenetics studies, supervised 4 laboratory technicians, wrote/reviewed SOPs, protocols, reports, created and implemented all associated study processes from study initiation to report distribution/review. Covance Laboratories Inc.
Study Director for all mammalian in vivo cytogenetics studies. Developed and validated a medium throughput in vitro micronucleus assay, requiring minimal amounts of test compound, for use as a genetic toxicology-screening assay. Responsibilities: Supervised 4-6 laboratory technicians, wrote/reviewed SOPs, protocols, reports, monitored all associated study processes from study initiation to report distribution/review. In vitro Cytogenetics Slide Reader
Microbiological Associates, Inc.
Study Director, in vitro cytogenetics Study Director for all mammalian in vitro cytogenetics studies. Responsibilities: Supervised 4-6 laboratory technicians, wrote/reviewed SOPs, protocols, reports, monitored all associated study processes from study initiation to report distribution/review. Warner Lambert/Parke-Davis
Post-Doctoral Fellowship Department of Pathology and Experimental Toxicology Responsible for designing experiments, supporting documentation, and reports in an investigational project assessing the genetic toxicity of a specific class of antibiotics. Study designs included development of SV40 viral assays for assessment of chromosome damage. University of Cincinnati School of Medicine
Post-Doctoral Traineeship, Molecular Genetics Developed proficiency in routine molecular biology techniques such as genetic analysis with restriction enzymes, plasmid preps, reporter gene construction, electroporation, etc. Education
Ph.D. 1988 University of Wyoming, Zoology and Physiology Department. Dissertation title: Cauda epididymal sperm interactions with seminal vesicle secretions -- protein kinase activity and phosphorylation. M.S. 1984 University of Wyoming, Zoology and Physiology Department. Thesis title: The induction of sister chromatid exchanges by sterigmatocystin and griseofulvin. B.S. 1978 Loras College, Biology Department. Dubuque, Iowa. PUBLICATIONS
Genetic toxicology and bone marrow cytotoxicity studies of the corticotropin-releasing hormone
(CRH) receptor antagonist, antalarmin. Toxicologist, 84, 362 (2005). P. T. Curry, M.
Nagabhushan, D. L. McCormick, R. E. Parchment, K. Calis, P. W. Gold, G. Cizza, D. Charney,
E. R. Glaze, and J. E. Tomaszewski.
Jacobson-Kram, D., J. Tepper, P. Kuo, R.H.C. San, P.T. Curry, V.O. Wagner and D. Putman
1997. Evaluation of potential genotoxicity of pulsed electric and electromagnetic fields used for
bone growth stimulation. Mutation Research, 338:45-57.
Curry, P. T., M.L. Kropko, J.R. Garvin, R.D. Fiedler and J. Theiss. 1996. In vitro induction of
micronuclei and chromosome aberrations by quinolones: possible mechanisms. Mutation
Research 352:143-150.
Motimaya, A. M., P. T. Curry, and R. M. Kitchin. 1994. Lack of induction of micronuclei by
clinical dose levels of azidothymidine (AZT) in vivo in mouse bone marrow cells.
Environmental and Molecular Mutagenesis 23:74-76.
Motimaya, A. M., P. T. Curry, and R. M. Kitchin. 1994. Evaluation of the genetic toxicity of
selected anti-AIDS treatment drugs at clinical doses in vivo in mice. Toxicology Letters 70:171-
183.
Subramanya, K. S., A. M. Motimaya, P. T. Curry, and R. M. Kitchin. 1993. Assessment of
genotoxicity of two anti-Parkinsonian drugs (selegiline hydrochloride and bromocryptine
mesylate) in vivo in mouse bone marrow cells. Toxicology Letters 66:221-230.
Curry, P. T. and R. W. Atherton. 1992. Cauda epididymal sperm interaction with seminal
vesicle fluid. Molecular Reproduction and Development 33(1):67-73.
Van der Horst, G., P. T. Curry, R. M. Kitchin, W. Burgess, E. T. Thorne, D. Kwiatkowski, M.
Parker, and R.W. Atherton. 1991. Quantitative Light and Scanning Electron Microscopy of
Ferret Sperm. Molecular Reproduction and Development 30:232-240.
Curry, P. T. and R. W. Atherton. 1990. Seminal vesicles: development, secretory products, and
fertility. Archives of Andrology. 25:107-113.
Curry, P. T., T. Ziemer, D. P. Waller, L. J. Zaneveld, and R. M. Kitchin. 1990. The lack of
mutagenicity of aryl 4-guanidino-benzoates in the transplacental micronucleus assay in mice.
Reproductive Toxicology 4:153-156.
Van der Horst, G., M. Farris, P.T. Curry, R. Kitchin, and R. W. Atherton. 1989. Abnormal
sperm; species, inbreeding, age, and season. Proc. Electron Microscopy Soc. S. Africa 19:149-
150.
Van der Horst, G., R.W. Atherton, P.T. Curry, and R.M. Kitchin. 1989. Use of membrane
filters and osmium tetroxide etching in the preparation of sperm for scanning electron
microscopy. J. Electron Microscopy Tech. 12:65-70.
Atherton, R.W., M. Straley, P.T. Curry, R. Slaughter, W. Burgess, and R.M. Kitchin. 1989. A
brief review of reproduction in the domestic ferret with comments on ovulation, fertilization, and
sperm cryopreservation. In, Proceedings of the Workshop on the Reproductive Biology of the
Black-Footed Ferret. Eds., Seal, U., E. T. Thorne, M. A. Bogan, and S. A. Anderson. Yale
University Press.
Atherton, R.W., M. Straley, P.T. Curry, R. Slaughter, W. Burgess, and R.M. Kitchin. 1989.
Domestic ferret electroejaculation and characterization and cryopreservation of ferret sperm: A
progress report. In, Proceedings of the Workshop on the Reproductive Biology of the Black-
footed Ferret. Eds., Seal, U., E. T. Thorne, M. A. Bogan, and S. A. Anderson. Yale University Press. Curry, P.T., T. Ziemer, M. Straley, G. Van der Horst, R.W. Atherton, and R.M. Kitchin. 1989.
Comparison of sperm morphology and silver nitrate staining characteristics in the European
ferret and the black-footed ferret. Gamete Research 22:27-36.
Kitchin, R.M., C.S. Walton, R.M. Martino, and P.T. Curry. 1987. In vivo induction of sister
chromatid exchange by clinical doses of haloperidol in Swiss albino mice. Environmental and
Molecular Mutagenesis 10:433-436.
Kitchin, R.M., P.T. Curry, and S.D. Levin. 1987. In vivo induction of micronuclei and sister
chromatid exchange by oil shale retort waters. In, Health and Environmental Research on
Complex Organic Mixtures, Twenty Fourth Hanford Life Sciences Symposium. Eds., Gray,
R.H., E.K. Chess, P.J. Mellinger, R.G. Riley, and D.L. Springer. Pacific Northwest Laboratory,
Richland, WA.
Curry, P.T., C.L. Hoffman, and R.W. Atherton. 1986. Epididymal sperm cAMP-dependent
and cAMP-independent protein kinase activity and phosphorylation in the rat. Arch. of Androl.
16(3):227-234.
Curry, P.T., R.N. Reed, R.M. Martino, and R.M. Kitchin. 1984. Induction of sister chromatid
exchanges in vivo by the mycotoxins sterigmatocystin and griseofulvin. Mutation Research
137:111-115.
PUBLISHED ABSTRACTS
M.J. Aardema, P.T. Curry, R. Gudi, and D.L. Putman. 1996. Griseofulvin-induced structural
and numerical chromosome aberrations in vitro and in vivo. Annual Meeting of the
Environmental Mutagen Society, Victoria, B.C., Canada, in Environmental and Molecular
Mutagenesis, 27 (Supplement 27):33.
D. Jacobson-Kram, J. Tepper, P. Kuo, R.H.C. San, P.T. Curry, V.O. Wagner, and D.L. Putman.
1996. Evaluation of potential genotoxicity of pulsed electromagnetic fields used for tissue
growth stimulation. Annual Meeting of the Environmental Mutagen Society, Victoria, B.C.,
Canada, in Environmental and Molecular Mutagenesis, 27(supplement 27):33.
D. Jacobson-Kram, J. Tepper, P. Kuo, R.H.C. San, P.T. Curry, V.O. Wagner and D.L. Putman.
1996. Evaluation of potential genotoxicity of pulsed electric fields used for bone growth
stimulation. Annual Meeting of the Environmental Mutagen Society, Victoria, B.C., Canada, in
Environmental and Molecular Mutagenesis, 27(supplement 27):33.
Curry, P.T., D. Monteith, M. Kropko, and J.C. Theiss. 1993. Quinolone inhibition of
topoisomerase II: evidence for more than one mechanism. Annual Meeting of the Environmental
Mutagen Society, Norfolk, Va., in: Environmental and Molecular Mutagenesis, 21(supplement
22):16.
Curry, P.T., M. Kropko, R. Fiedler, J. Garvin, and J. C. Theiss. 1993. Assessment of the
clastogenic and aneugenic activity of the quinolones, ciprofloxacin and PD124816. Annual
Meeting of the Environmental Mutagen Society, Norfolk, Va., in: Environmental and Molecular
Mutagenesis, 21(supplement 22):16.
Curry, P.T., M. Kropko, J. Garvin, R. Fiedler, and J. Theiss. 1992. Inhibition of quinolone
induction of micronuclei by caffeine. Annual Meeting of the Environmental Mutagen Society,
Reno, Nevada, in: Environmental and Molecular Mutagenesis, 19(supplement 20):12.
Van der Horst, G., K.S. Nichols, B. Paul, P.T. Curry, R.M. Kitchin, M. Parker, and R.W.
Atherton. 1990. Comparative spermatology of three ferret species in a captive breeding
programme. Presented at the Physiology Conference of South Africa. Sept. 5-7.
Van der Horst, G., K.S. Nichols, B. Paul, P.T. Curry, R.M. Kitchin, M. Parker, and R.W.
Atherton. 1990. Acrosome integrity and percent eosinophilic sperm of fresh versus
cryopreserved ferret semen. Presented at the Annual meeting of the Southern African Society of
Reproductive Biologists. Nov. 30.
Bhatia, A., P.T. Curry, S. Feckley, and R. Kitchin. 1989. Assessment of the genotoxicity of
anti-AIDS drugs with the in vivo mouse bone marrow micronucleus assay. Colo-Wyo Acad. Sci.
6:4.
Bhatia, A., P.T. Curry, S. Feckley, and R. Kitchin. 1989. Assessment of the genotoxicity of
anti-AIDS drugs with the in vivo mouse bone marrow micronucleus assay. Kansas Acad. of Sci.
6:4.
Kitchin, R., P.T. Curry, M. Parker, and R. Atherton. 1989. Semen quality and fertility of the
Black-footed ferret. Colo-Wyo Acad. Sci. 21:6.
Atherton, R., R. Kitchin, P.T. Curry, M. Parker, and G. Van Der Horst. 1989. Comparison of
sperm morphology, motility, and semen quality in the Black-footed ferret, Siberian ferret, and
European ferret. Serono Symposium on Fertility in Mammals. Boston, Mass.
Curry, P.T., M. Straley, W. Burgess, M. Parker, R.W. Atherton, and R.M. Kitchin. 1988.
Computer analysis of sperm motility and morphological characteristics in three species of ferret.
Presented at the annual meeting of the Society for the Study of Reproduction. Seattle,
Washington.
Curry, P.T., M. Parker, R.W. Atherton, and R.M. Kitchin. 1988. Comparisons of semen
parameters of European, Siberian, and Black-footed ferrets. Colo-Wyo Acad. Sci. 20:73.
Kitchin, R.M., P.T.Curry, W. Burgess, M. Straley, M. Parker, and R.W. Atherton. 1988.
Comparison of semen sperm content and sperm motility of European, Siberian, and Black-footed
Ferrets. Proceedings of the American Society of Andrology Meetings, Houston, Texas.
Curry, P.T., and R.M. Kitchin. 1987. In vivo induction of sister chromatid exchange and
micronuclei in mice by haloperidol. Proc. 5th Annual Meeting of Mountain West Chapter of the
Society of Toxicology. (a45).
Kitchin, R.M., P.T. Curry, and S.D. Levin. 1986. In vivo mutagenicity of oil shale waters in
mice. Colo-Wyo Acad. of Sci. 18:49.
Curry, P.T., R.M. Martino, C.S. Moser, and R.M. Kitchin. 1986. Evaluation of mutagenicity of
haloperidol in vivo in mice. Colo-Wyo Acad. Sci. 18:49.
Kitchin. R.M., P.T. Curry, and S.D. Levin. 1985. In vivo induction of micronuclei and sister
chromatid exchange by oil shale retort waters. Accepted for presentation at the Twenty Fourth
Hanford Life Sciences Symposium: Health and Environmental Research on Complex Organic
Mixtures.
Curry, P.T., R.M. Martino, C.S. Moser, and R.M. Kitchin. 1985. In vivo induction of sister
chromatid exchanges in mice by haloperidol. Colo.-Wyo. Acad. Sci. 17:10.
Curry, P.T., R.N. Reed, R. Martino, and R.M. Kitchin. 1983. Induction of sister chromatid
exchanges by plant mycotoxins. Colo.-Wyo. Acad. of Sciences. 15:17.
Professional Memberships
Professional Address
Food and Drug Administration 5100 Paint Branch Parkway, HFS-275 College Park, MD 20740-3835

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