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Environmental Factors Which Cause Birth Defects
APRIL 22-24, 2012
offered by the
at the
under the direction of
Lewis B. Holmes, MD and Associates
Guest Speakers
Nancy L. Day, PhD, MPH
Judith G. Hal , MD
Anthony R. Scial i, MD
University of Pittsburgh
University of British Columbia
Reproductive Toxicology Center
There is now widespread concern about the teratogenic ef ects of drugs, maternal diseases; chemicals in the environment, infectious agents and exposure to radiation. Faculty includes clinicians, epidemiologists, basic scientists, obstetricians, and pediatricians with first hand experience. The teaching method to be used is didactic lectures with question and answer sessions at the end.
At the end of this course, participants wil be able to: Analyze the scientific data available to determine whether an exposure in utero poses a potential risk for damage to the fetus.
Use online databases and published articles as a resource to gain information on the ef ect of various teratogens on the unborn fetus.
Counsel your patients who have experienced an environmental exposure so they understand the possible risks to the fetus in utero.
Develop a strategy for evaluating new published findings and deciding whether to include them in counseling your patients.
Obstetricians, geneticists, genetic counselors, nurse midwives, nurse in obstetrics, nurse practitioners, pediatricians, family practitioners, internists.
This course is designed to enhance the fol owing ACGME competencies: • medical knowledge • patient care • practice-based learning and improvement ACCREDITATION
The Harvard Medical School is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for The Harvard Medical School designates this live activity for a maximum of 22 AMA PRA Category 1 CreditsTM. Physicians should claim only the credit
commensurate with the extent of their participation in the activity.
The Massachuset s Association for Registered Nurses, Inc. (MARN) has approved this course for 22 contact hours. National Society of Genetic
Counselors (NSGC) — approval pending.
Tuition Fee — $650 (USD). Reduced Fee for Genetics and Maternal Fetal Medicine Residents/Fel ows – $200 (USD) and Al ied Health
Professionals – $350 (USD). Registration by credit card (VISA or MasterCard) can be made at:
Registration by check (draft on a United States bank), please make payable to Harvard Medical School and mail with registration form to Harvard
Medical School-Department of Continuing Education, PO Box 825, Boston, MA 02117-0825. Telephone and fax registration is not accepted.
On-site registration with cash payment is not accepted. Upon receipt of your paid registration an email confirmation from the HMS-DCE of ice wil be sent to you. Be sure to include an email address that you check frequently. Your email address is used for critical information including: registration confirmation, evaluation and certificate.
To register or view activity information online, visit
To ensure proper registration, please add the first three characters of the source code found at the bottom of this registration form.
Harvard Medical School (HMS) adheres to al ACCME Essential Areas, Standards, and Policies. It is HMSʼs policy that those who have influenced the content of a CME activity (e.g. planners, faculty, authors, reviewers and others) disclose al relevant financial relationships with commercial enti- ties so that HMS may identify and resolve any conflicts of interest prior to the activity. These disclosures wil be provided in the activity materials along with disclosure of any commercial support received for the activity. Additional y, faculty members have been instructed to disclose any limita- tions of data and unlabeled or investigational uses of products during their presentations.
A handling fee of $60 is deducted for cancel ation. Refund requests must be received by postal mail, email or fax one week prior to this activity. No INQUIRIES
By telephone 617-384-8600, Monday-Friday, 10 AM to 4 PM (EST) or by email at:
Al sessions for this activity wil be held at the Richard B. Simches Research Center, Charles River Plaza, 185 Cambridge St., Boston MA 02114.
A limited number of rooms have been reserved at the Holiday Inn at Beacon Hil , Boston MA (Telephone: 617-742-0461) until March 31, 2012.
Please specify that you are enrol ed in this activity to receive a reduced room rate. Please do not purchase non-refundable airline ticket(s) until you have received an email from our of ice confirming your paid registration. For airline reservations contact the HMS Travel Desk tol free 1(877) 4-HARVMD (1-877-442-7863) Monday - Friday 9 AM - 8 PM (EST). From outside the U.S., Canada and Virgin Islands, please cal (617) 559-3764.
April 22-24, 2012
Tuition Fee: $650 (USD)
Print Name Clearly
Al ied Health Professionals: $350 (USD)
Al Fields Required
Genetics/Maternal Fetal Medicine Residents/Fel ows: $200 (USD)
Ful Name_________________________________________________________________________________________________________________________ Mailing Address _______________________________________________________________________________________________________ Daytime Phone (_________ ) ___________________________________ Fax Number ( ________ ) ___________________________________________ Please note: Your email address is used for critical information about the course including; registration confirmation, evaluation and certificate. Please be sure to include
an email address you check daily or frequently.
E-Mail Address____________________________________________________________________________________________________________________ Please check if you wish to be excluded from receiving e-mail notices of future Harvard Medical School — Department of Continuing Education programs
Profession __________________________________________ Degree __________________________________________________________Primary Specialty (Physicians only) ____________________________________________________________________ Board Certified: Yes ❑ No ❑ Professional School At ended (Physicians only) ❑ Harvard Medical School ❑ U.S. Medical School ❑ International Year of Graduation ____________ Online Registrants — add the first three characters of the source code found here Ł
Source Code: A B C D E F G H I J K L M X Z Z Z
SUNDAY, APRIL 22, 2012
MONDAY, APRIL 23, 2012 (continued)
Moderator: Lewis B. Holmes, MD
Moderator: Lewis B. Holmes, MD
7:00- 8:00 Registration — Simches Research Center — 3rd Floor 1:00- 2:00 Fetal Ef ects of Caf eine. . . . . . . . Michael F. Greene, MD 8:00- 9:00 Principles of Teratology . . . . . . . . . Lewis B. Holmes, MD 2:00- 3:00 Fetal Ef ects of Alcohol. . . . . . . Nancy L. Day, PhD, MPH 9:00-10:00 Principles of Epidemiology . . . . . . . . . Jennita Reefhuis, PhD 3:30- 4:30 Fetal Ef ects of Cocaine . . . . . . . . . . Linda C. Mayes, MD Principles of Embryology. . . . . . . . Anthony R. Scial i, MD 11:20-12:20 Epigenetics . . . . . . . . . . . . . . . . . . . . . . . . Judith G. Hal , MD Smoking . . . . . . . . . . . . . . . . . Nancy L. Day, PhD, MPH MATERNAL CONDITIONS
Moderator: Michael F. Greene, MD
1:30- 2:30 Maternal Obesity . . . . . . . . . . . . . Michael F. Greene, MD Moderator: Lewis B. Holmes, MD
Diseases. . . . . . . . . . . . . . John Patrick Whelan, MD, PhD 8:00- 8:50 Animal Models . . . . . . . . . . . . . . . . . Anthony R. Scial i, MD 3:40- 4:30 Thyroid Disease in Pregnancy . . . . . . Gilbert H. Daniels, MD Drug Labeling . . . . . . . . . . . . . . . . . . . . Leyla Sahin, MD 4:30- 5:30 Prevention of Birth Defects: Folic acid, iodide, thyroid supplements . . . . . . Godfrey P. Oakley, MD Thalidomide . . . . . . . . . . . . . . . . . . . Marilyn T. Mil er, MD Clomid . . . . . . . . . . . . . . . . . . . . . . Jennita Reefhuis, MD MONDAY, APRIL 23, 2012
Moderator: Louise E. Wilkens-Haug, MD, PhD
Moderator: Lewis B. Holmes, MD
Technology . . . . . . . . Louise E. Wilkins-Haug, MD, PhD 9:00- 9:50 Phthalates & Developmental 1:15- 2:05 Coumadin . . . . . . . . . . . . . . . . . . . . . . . . Judith G. Hal , MD Endpoints. . . . . . . . . . . . . . . . Russ B. Hauser, MD, ScD 2:05- 2:55 Valproate . . . . . . . . . . . . . . . . . . . . . Godfrey P. Oakley, MD Bisphenol A . . . . . . . . . . Joseph Braun, MSPH, PhD, RN 3:15- 4:05 Cancer and Pregnancy. . . . . . . . Erica L. Mayer, MD, MPH PREGNANCY REGISTRIES
Developing Fetus . . . . . . . . . . . . . . . . . Kim Harley, PhD 4:05- 4:55 Pregnancy Registries . . . . . . . . . . Lewis B. Holmes, MD Please note: Program changes/substitutes may be made without notice.
Joseph Braun, MSPH, Ph.D., RN, Research Fel ow in Department of Environmental health at Harvard School of Public Health,
Gilbert H. Daniels, M.D., Co-Director Thyroid Clinic, Co-Director Endocrine Tumor Genetics Clinic, Massachusetts General
Hospital, Boston; Professor of Medicine, Harvard Medical School. Nancy L. Day, Ph.D., M.P.H., Professor of Psychiatry and Epidemiology; Director of the Maternal Health Practices and Child
Development Program at the University of Pit sburgh School of Medicine, Pit sburgh, PA. Michael F. Greene, M.D., Chief of Obstetrics, Department of Obstetrics and Gynecology, Massachuset s General Hospital, Boston;
Professor of Obstetrics, Gynecology and Reproductive Biology, Harvard Medical School. Judith G. Hal , M.D., Professor Emerita of Pediatrics and Medical Genetics, University of British Columbia, Vancouver, Canada.
Kim Harley, Ph.D., Assistant Adjunct Professor, Associate Director for Health Ef ects, Center for Environmental Research and
Childrenʼs Health, University of California-Berkeley. Russ B. Hauser, M.D., Sc.D., MPH, Frederick Lee Hisaw Professor of Reproductive Physiology, Professor of Environmental and
Occupational Epidemiology, Harvard School of Public Health; Professor of Obstetrics, Gynecology and Reproductive Biology, Lewis B. Holmes, M.D., Chief Emeritus, Genetics Unit, MassGeneral Hospital for Children, Boston; Professor of Pediatrics, Harvard
Erica L. Mayer, M.D., M.P.H., Director of Clinical Research, Dana-Farber at Faulkner Hospital; Breast Medical Oncologist; Dana-
Farber Cancer Institute, Boston; Assistant Professor in Medicine, Harvard Medical School. Linda C. Mayes, M.D., Arnold Gesel Professor, Yale Child Study Center; Professor of Epidemiology (Chronic Diseases), Pediatrics
and Psychology, Yale University Medical Center, New Haven, CT; Chair, Directorial Team Anna Freud Centre, London, UK. Marilyn T. Mil er, M.D., Professor of Ophthalmology, University of Il inois Col ege of Medicine, Chicago, IL.
Godfrey P. Oakley, Jr., M.D., MSPM, Research Professor of Epidemiology, Rol ins School of Public health of Emory University,
Jennita Reefhuis, Ph.D., Epidemiologist, Epidemiology Team, Birth Defects Branch, National Center on Birth Defects and
Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, GA. Leyla Sahin, M.D., Medical Of icer, Pediatric and Maternal Health Team, Maternal Health Team, Of ice of New Drugs, CDER/FDA,
Anthony R. Scialli, M.D., Director, Reproductive Toxicology Center, Washington, DC; Clinical Professor of Obstetrics and
Gynecology, George Washington University School of Medicine, Washington, DC; Adjunct Professor of Obstetrics and Gynecology and of Pharmacology and Physiology, Georgetown University School of Medicine, Washington, DC. John Patrick Whelan, M.D., Ph.D., Associate in Pediatrics, Rheumatology, MassGeneral Hospital for Children, Boston, MA.
Assistant Professor of Pediatrics, USC Keck School of Medicine, Childrenʼs Hospital, Los Angeles, CA. Louise Wilkins-Haug, M.D., Ph.D., Director, Maternal Fetal Medicine, Brigham and Womenʼs Hospital, Boston; Associate
Professor, Obstetrics, Gynecology and Reproductive Biology, Harvard Medical School.



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