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Microsoft powerpoint - sulhpoxide_microreactor_production.ppt [compatibility mode]

NCL Innovations: Solutions from CSIR India Sulphoxide compounds such as modafinil/prazole compounds are currently produced by batch synthesis procedure  The process yields about 85% product over a duration of 1-4 hours under low temperatures- leading to long processing times A more efficient process is required at the industrial level  These compounds are mainly used as proton pump inhibitors  Which consumes less time and yields lower unnecessary side products continually unlike the Our process is a continuous flow synthesis of sulphoxide compounds with reaction times of ≤ 1 minute  The reaction results in over 90% conversion and over 95% selectivity towards the target sulphoxide compounds (with less than 5% formation of undesired sulphone compounds) The process can be used to make the following drugs which are mainly used as proton pump inhibitors- used to make drugs to treat the acid-related diseases of the gastrointestinal (GI) tract  Such as omeprazole, pantoprazole, lansoprazole, tenatoprazole, rabeprazole, The process can also be used to make drug molecules that can be used as modafinil compounds  Which can be used as central nervous system stimulants- wakefulness promoting agents*  In production of drugs which act as neuroprotective agents * GI disorders have been projected to affect more than a 250 million people in the 7 large pharma markets by 20121  Overall GI tract disorders treatment market is expected to reach $32.2 billion by 20142 In 2009, proton pump inhibitors were the third largest ther amounting up to $13.6 billion of sales in the US3 2  The process is continuous with the reaction time of ≤ 1 minute Results in high yield of the product with 95% of selectivity towards the sulphoxide compounds  Side product (sulphone compounds) formation- less than 5% volatile solvent that evaporates at room temperature and changes the reaction mass)  WO/ PCT application: PCT/IN2010/000456 ) )Micromixer as a Continuous Flow Reactor for the Synthesis of a Pharmaceutical Intermediate, Korean J. Chem. Eng., 20(2), 268-272 Contact Info:
Dr. Magesh N.
Scientist, NCL Innovations
National Chemical Laboratory
Pune - 411008
Phone: +91-20-2590-2982
Email: m(dot)nandagopal(at)ncl(dot)res(dot)in Technology Summary
Continuous flow synthesis of sulphoxide compounds for use in drug fo Technology readiness level Demonstrated at lab levelLicensing status


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LEVINAS, PSYCHOTHERAPY, AND THE ETHICS OF SUFFERING EDWIN E. GANTT is an assistant professor ofpsychology at Brigham Young University inProvo, Utah. He received his doctorate in psychol-ogy at Duquesne University in 1998. He is the au-thor of several articles on Levinas and psychol-ogy, including “Truth, Freedom, and Responsibil-ity in the Dialogues of Psychotherapy,” “SocialCon- stru


Back on the Streets Without a Safety Net; Critics Assail Lack of Followup Care For Free. September 13, 1999 Back on the Streets Without a Safety Net; Critics Assail Lack of Followup Care For Freed Inmates With Mental Ills By NINA BERNSTEIN In the gloom before dawn, under the hulking metal girders in Queens Plaza, the Department of Correction bus cruised to a stop. The doors opened

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