NCL Innovations: Solutions from CSIR India
Sulphoxide compounds such as modafinil/prazole compounds are currently produced by batch synthesis procedure
The process yields about 85% product over a duration of 1-4 hours under low
temperatures- leading to long processing times
A more efficient process is required at the industrial level
These compounds are mainly used as proton pump inhibitors
Which consumes less time and yields lower unnecessary side products continually unlike the
Our process is a continuous flow synthesis of sulphoxide compounds with reaction times of ≤ 1 minute
The reaction results in over 90% conversion and over 95% selectivity towards the target
sulphoxide compounds (with less than 5% formation of undesired sulphone compounds)
The process can be used to make the following drugs which are mainly used as proton pump inhibitors- used to make drugs to treat the acid-related diseases of the gastrointestinal (GI) tract
Such as omeprazole, pantoprazole, lansoprazole, tenatoprazole, rabeprazole,
The process can also be used to make drug molecules that can be used as modafinil compounds
Which can be used as central nervous system stimulants- wakefulness promoting agents*
In production of drugs which act as neuroprotective agents
* http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=4236
GI disorders have been projected to affect more than a 250 million people in the 7 large pharma markets by 20121
Overall GI tract disorders treatment market is expected to reach $32.2 billion by 20142
In 2009, proton pump inhibitors were the third largest ther
amounting up to $13.6 billion of sales in the US3
http://www.astrazeneca-annualreports.com/documents/2010/therapy_review_area_factsheets/gastrointestinal.pdfhttp://www.prnewswire.com/news-releases/reportlinker-adds-gastrointestinal-pharmaceuticals-technologies-and-markets-68849697.html 2http://www.imshealth.com/portal/site/imshealth/menuitem.a46c6d4df3db4b3d88f611019418c22a/?vgnextoid=d690a27e9d5b7210VgnVCM100000ed152ca2RCRD3
The process is continuous with the reaction time of ≤ 1 minute
Results in high yield of the product with 95% of selectivity towards the sulphoxide compounds
Side product (sulphone compounds) formation- less than 5%
volatile solvent that evaporates at room temperature and changes the reaction mass)
WO/ PCT application: PCT/IN2010/000456
) )Micromixer as a Continuous Flow Reactor for the
Synthesis of a Pharmaceutical Intermediate, Korean J. Chem. Eng., 20(2), 268-272
Contact Info:
Technology SummarySource: http://www.nclinnovations.org/pdfs/available_knowhow/Sulhpoxide_Microreactor_production.pdf
LEVINAS, PSYCHOTHERAPY, AND THE ETHICS OF SUFFERING EDWIN E. GANTT is an assistant professor ofpsychology at Brigham Young University inProvo, Utah. He received his doctorate in psychol-ogy at Duquesne University in 1998. He is the au-thor of several articles on Levinas and psychol-ogy, including “Truth, Freedom, and Responsibil-ity in the Dialogues of Psychotherapy,” “SocialCon- stru
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