Microsoft word - sci_program_muswas_2013_final

EMBO Workshop
Molecular mechanisms of muscle growth and wasting
in health and disease
Centro Stefano Franscini, Ascona, Switzerland

16.00 - 18.00

18.00 - 19.30
Reception with food and drinks
Keynote Lecture
TOR signaling in growth and metabolism Molecular mechanisms of muscle growth and wasting in health and disease 2013 MONDAY

08.45 - 09.00
Welcome speech and introduction to Centro Stefano Franscini Repair mechanisms of skeletal muscle

Molecular regulation of muscle stem cell function. Satellite cell quiescence and self renewal Short talks
Maturation of myofiber is mediated by transit double cortin-expressing myogenic cells during regeneration 3D tissue-engineered muscle with satellite cell niche exhibits unparallel contractile function and robust vascularization Coffee Break
The molecular regulation of muscle stem cell quiescence Rescue of a cell-autonomous loss of asymmetric division and self-renewal in aged skeletal muscle stem cells Short talks
Collagen VI is a key component of muscle stem cell niche required for muscle regeneration Identification of a stress-activated pathway that reprograms skeletal muscle gene expression and promotes muscle atrophy
12.30 - 14.30
Lunch Break
Disease of the nerve-muscle connection

Satellite cell functions and the control of muscle repair and growth during aging Mechanisms of LRP4 in neuromuscular junction formation and muscular dystrophy Short talks
Postnatal deletion of Pofut1 in mouse skeletal myofibers inhibits NotchR signaling and reduces skeletal muscle growth and regeneration Pathogenic mechanisms in MUSK Myasthenia Gravis Coffee Break
Mouse models of SMA: Therapeutics and basic biology of SMA Short talks
Characterization of skeletal muscle conditional ERK2- and ERK1/2-deficient mice Epigenetic regulation of neurogenic muscle atrophy
18.00 - 19.00
Poster Session (with drinks and snacks)
Poster Session (continued)
Molecular mechanisms of muscle growth and wasting in health and disease 2013 Excitation-contraction coupling; calcium handling; mitochondria

Skeletal Muscle Regulation of Body Composition: The Role of Ca2+ Influx via CaV1.1 Myomaker is a membrane activator of myoblast fusion and muscle formation Short talks
Enhanced dihydropyridine receptor calcium channel activity in skeletal muscle from JP-45 and calsequestrin 1 double knock-out mice restores muscle strength Small molecule fast skeletal troponin activator CK-2066260 improves Ca2+ sensitivity, sub- maximal muscle force and exercise capacity
10.30 - 11.00
Coffee Break
Making Muscle by Protein Tyrosine Dephosphorylation Therapeutic potential of heat shock protein induction for muscle wasting conditions Short talks
Studying developmental muscle atrophy and cell death using live imaging of Drosophila metamorphosis and image analysis
12.30 - 14.30
Lunch Break
Mechanisms controlling muscle size

Pak1 and Pak2 kinases promote skeletal myogenesis mTOR and the control of autophagy in skeletal muscle Short talks
eIF4EBP3L Acts as a gatekeeper of TORC1 in activity-dependent muscle growth by regulating Mef2ca translational initiation Role of acylated and unacylated ghrelin in skeletal muscle regeneration
16.00 - 16.30
Coffee Break
Novel signaling pathways that control muscle atrophy and hypertrophy Stem cells in cancer-induced muscle wasting Short talks
The Bone Morphogenetic Protein (BMP) signaling axis is a positive regulator of skeletal muscle mass Free Evening
Molecular mechanisms of muscle growth and wasting in health and disease 2013 WEDNESDAY
Epigenetics and microRNAs in muscle function

MG53-mediated skeletal muscle insulin resistance and resultant metabolic syndrome Charlet-Berguerand, N. microRNA and messenger RNA processing alterations in Myotonic Short talks
HuR and miR-1192 respectively promote and reduce myogenesis by modulating the translation of HMGB1 mRNA Activation of calcium signalling through TRPV1 by nNOS and peroxynitrite as a key trigger of skeletal muscle hypertrophy Coffee Break
FSHD muscular dystrophy: a walk on the dark side of the (epi)genome The chromatin modifier SMCHD1 is mutated in FSHD2 and acts as a modifier in FSHD1 Short talks
Humanizing mouse models of disease: Role of telomere dysfunction in Duchenne Muscular Dystrophy Identification of a new pathway involved in muscle regeneration and fibrosis in muscular dystrophy
12.30 - 14.30
Lunch Break
Metabolic dynamics; interaction of skeletal muscle with other organs

Transcriptional programming of the mitochondrial bioenergetics in skeletal muscle Regulation of skeletal muscle metabolism by Myostatin Short talks
AMPK-autophagy pathway determines myopathy formation in response to mitochondrial malfunction AMPKα1 regulates macrophage skewing at the time of resolution of inflammation during skeletal muscle regeneration Coffee Break
The methyltransferase SMYD3 regulates skeletal muscle mass Mechanisms controlling the switch between trophic and degenerative roles of mesenchymal stem cell in muscle regeneration
Short talks
17.30 - 17.45
Myostatin signals through the novel zinc finger containing protein menos musculo 1 (MM1) to promote skeletal muscle wasting A structural chromatin component linking muscle metabolism and epigenetic regulation
18.00 - 19.00
Poster Session (with drinks and snacks)
Poster Session (continued)
Molecular mechanisms of muscle growth and wasting in health and disease 2013 THURSDAY
Mechanisms of sarcopenia and cachexia

Muscle wasting and mitochondrial function Signaling pathways that mediate skeletal muscle atrophy, hypertrophy and aging Short talks
G protein coupled receptor 56 is a target gene of the PGC-1α4 isoform and regulates skeletal muscle hypertrophy REDD1 null mice resist to dexamethasone-induced skeletal muscle atrophy Coffee Break
Circadian Rhythms, the molecular clock and muscle: why muscle needs to keep time New insights into the regulation of FoxO signaling in skeletal muscle
Short talks
12.00 - 12.15
Blockade of activin receptor type II induces strong hypertrophy and protects from atrophy HSP72 overexpression protects against ventilator-induced diaphragm dysfunction Lunch Break
Muscular dystrophies and development of therapeutic strategies

Mechanistic insights into dystroglycan glycosylation and muscular dystrophy Matrix regulation of muscle degeneration in muscular dystrophy Short talks
Dystroglycan phosphorylation as a therapeutic target for Duchenne muscular dystrophy Acute phosphodiesterase5A inhibitor treatment restores blood flow and activity to active mdx muscle and restores active hyperemia to BMD muscle Coffee Break
Dynamic Pax3:Foxo1 oncogene expression drives checkpoint adaptation in rhabdomyosarcoma Rev-erbα modulates skeletal muscle oxidative capacity
Short talks
Impaired viability of muscle precursor cells in muscular dystrophy with glycosylation defects and amelioration of its severe phenotype by limited gene expression microRNAs as Modifiers of Dystrophin Protein Levels in Becker Muscular Dystrophy – Implications for Variability in Exon Skipping Aperitif and Gala Dinner
Molecular mechanisms of muscle growth and wasting in health and disease 2013 Breakfast and Departure



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