Microsoft word - sci_program_muswas_2013_final
EMBO Workshop
Molecular mechanisms of muscle growth and wasting
in health and disease
Centro Stefano Franscini, Ascona, Switzerland
15.9.2013-20.9.2013
16.00 - 18.00
18.00 - 19.30
Reception with food and drinks
Keynote Lecture
TOR signaling in growth and metabolism
Molecular mechanisms of muscle growth and wasting in health and disease 2013
MONDAY
08.45 - 09.00
Welcome speech and introduction to Centro Stefano Franscini
Repair mechanisms of skeletal muscle
Speakers
Molecular regulation of muscle stem cell function.
Satellite cell quiescence and self renewal
Short talks
Maturation of myofiber is mediated by transit double cortin-expressing myogenic cells during regeneration
3D tissue-engineered muscle with satellite cell niche exhibits unparallel contractile function and robust vascularization
Coffee Break
The molecular regulation of muscle stem cell quiescence
Rescue of a cell-autonomous loss of asymmetric division and self-renewal in aged skeletal muscle stem cells
Short talks
Collagen VI is a key component of muscle stem cell niche required for muscle regeneration
Identification of a stress-activated pathway that reprograms skeletal muscle gene expression and promotes muscle atrophy
12.30 - 14.30
Lunch Break
Disease of the nerve-muscle connection
Speakers
Satellite cell functions and the control of muscle repair and growth during aging
Mechanisms of LRP4 in neuromuscular junction formation and muscular dystrophy
Short talks
Postnatal deletion of Pofut1 in mouse skeletal myofibers inhibits NotchR signaling and reduces skeletal muscle growth and regeneration
Pathogenic mechanisms in MUSK Myasthenia Gravis
Coffee Break
Mouse models of SMA: Therapeutics and basic biology of SMA
Short talks
Characterization of skeletal muscle conditional ERK2- and ERK1/2-deficient mice
Epigenetic regulation of neurogenic muscle atrophy
18.00 - 19.00
Poster Session (with drinks and snacks)
Poster Session (continued)
Molecular mechanisms of muscle growth and wasting in health and disease 2013
Excitation-contraction coupling; calcium handling; mitochondria
Speakers
Skeletal Muscle Regulation of Body Composition: The Role of Ca2+ Influx via CaV1.1
Myomaker is a membrane activator of myoblast fusion and muscle formation
Short talks
Enhanced dihydropyridine receptor calcium channel activity in skeletal muscle from JP-45 and calsequestrin 1 double knock-out mice restores muscle strength
Small molecule fast skeletal troponin activator CK-2066260 improves Ca2+ sensitivity, sub- maximal muscle force and exercise capacity
10.30 - 11.00
Coffee Break
Making Muscle by Protein Tyrosine Dephosphorylation
Therapeutic potential of heat shock protein induction for muscle wasting conditions
Short talks
Studying developmental muscle atrophy and cell death using live imaging of Drosophila metamorphosis and image analysis
12.30 - 14.30
Lunch Break
Mechanisms controlling muscle size
Speakers
Pak1 and Pak2 kinases promote skeletal myogenesis
mTOR and the control of autophagy in skeletal muscle
Short talks
eIF4EBP3L Acts as a gatekeeper of TORC1 in activity-dependent muscle growth by regulating Mef2ca translational initiation
Role of acylated and unacylated ghrelin in skeletal muscle regeneration
16.00 - 16.30
Coffee Break
Novel signaling pathways that control muscle atrophy and hypertrophy
Stem cells in cancer-induced muscle wasting
Short talks
The Bone Morphogenetic Protein (BMP) signaling axis is a positive regulator of skeletal muscle mass
Free Evening
Molecular mechanisms of muscle growth and wasting in health and disease 2013
WEDNESDAY
Epigenetics and microRNAs in muscle function
Speakers
MG53-mediated skeletal muscle insulin resistance and resultant metabolic syndrome
Charlet-Berguerand, N.
microRNA and messenger RNA processing alterations in Myotonic
Short talks
HuR and miR-1192 respectively promote and reduce myogenesis by modulating the translation of HMGB1 mRNA
Activation of calcium signalling through TRPV1 by nNOS and peroxynitrite as a key trigger of skeletal muscle hypertrophy
Coffee Break
FSHD muscular dystrophy: a walk on the dark side of the (epi)genome
The chromatin modifier SMCHD1 is mutated in FSHD2 and acts as a modifier in FSHD1
Short talks
Humanizing mouse models of disease: Role of telomere dysfunction in Duchenne Muscular Dystrophy
Identification of a new pathway involved in muscle regeneration and fibrosis in muscular dystrophy
12.30 - 14.30
Lunch Break
Metabolic dynamics; interaction of skeletal muscle with other organs
Speakers
Transcriptional programming of the mitochondrial bioenergetics in skeletal muscle
Regulation of skeletal muscle metabolism by Myostatin
Short talks
AMPK-autophagy pathway determines myopathy formation in response to mitochondrial malfunction
AMPKα1 regulates macrophage skewing at the time of resolution of inflammation during skeletal muscle regeneration
Coffee Break
The methyltransferase SMYD3 regulates skeletal muscle mass
Mechanisms controlling the switch between trophic and degenerative roles of mesenchymal stem cell in muscle regeneration
Short talks 17.30 - 17.45
Myostatin signals through the novel zinc finger containing protein menos musculo 1 (MM1) to promote skeletal muscle wasting
A structural chromatin component linking muscle metabolism and epigenetic regulation
18.00 - 19.00
Poster Session (with drinks and snacks)
Poster Session (continued)
Molecular mechanisms of muscle growth and wasting in health and disease 2013
THURSDAY
Mechanisms of sarcopenia and cachexia
Speakers
Muscle wasting and mitochondrial function
Signaling pathways that mediate skeletal muscle atrophy, hypertrophy and aging
Short talks
G protein coupled receptor 56 is a target gene of the PGC-1α4 isoform and regulates skeletal muscle hypertrophy
REDD1 null mice resist to dexamethasone-induced skeletal muscle atrophy
Coffee Break
Circadian Rhythms, the molecular clock and muscle: why muscle needs to keep time
New insights into the regulation of FoxO signaling in skeletal muscle
Short talks 12.00 - 12.15
Blockade of activin receptor type II induces strong hypertrophy and protects from atrophy
HSP72 overexpression protects against ventilator-induced diaphragm dysfunction
Lunch Break
Muscular dystrophies and development of therapeutic strategies
Speakers
Mechanistic insights into dystroglycan glycosylation and muscular dystrophy
Matrix regulation of muscle degeneration in muscular dystrophy
Short talks
Dystroglycan phosphorylation as a therapeutic target for Duchenne muscular dystrophy
Acute phosphodiesterase5A inhibitor treatment restores blood flow and activity to active mdx muscle and restores active hyperemia to BMD muscle
Coffee Break
Dynamic Pax3:Foxo1 oncogene expression drives checkpoint adaptation in rhabdomyosarcoma
Rev-erbα modulates skeletal muscle oxidative capacity
Short talks
Impaired viability of muscle precursor cells in muscular dystrophy with glycosylation defects and amelioration of its severe phenotype by limited gene expression
microRNAs as Modifiers of Dystrophin Protein Levels in Becker Muscular Dystrophy – Implications for Variability in Exon Skipping
Aperitif and Gala Dinner
Molecular mechanisms of muscle growth and wasting in health and disease 2013
Breakfast and Departure
Source: http://www.musclewasting.ch/fileadmin/Medias/Program_Final.pdf
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