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PHARMACEUTICAL METABOLISM PATHWAYS
Acenocoumarol (Sintrom)
Anticoagulant
Felodipine
Perhexiline
Antianginal
Acetaminophen (Paracetamol)
Analgesic
Fentanyl (Actiq)
Perphenazine (Trilafon)
Antipsychotic
Agomelatine (Valdoxan, Melitor)
Antidepressant
Fesoterodine fumarate (Toviaz)
Phenacetin
Non-opiod Analg
Alfentanil (Alfenta)
Opiod Analgesic
Finasteride (Proscar, Propecia)
Phenformin
Diabetes
Alfuzosin (Uroxatral)
Flecainide (Tambacor)
Antiarrhythmic
Phenobarbital
Anticonvulsant
Alprazolam (Xanax)
Fluoxetine (Prozac)
Phenprocoumon
Anticoagulant
Alprenolol
B Blocker
Flurbiprofen (Ansaid, Froben, Ocufen)
Phentermine
Amiodarone
Antiarrhythmic
Fluvastatin (Lescol, Canef, Vastin)
Phenytoin (Phenytek, Dilantin)
Anticonvulsant
Amitriptyline (Elavil)
Fluvoxamine (Luvox)
Pimozide (Orap)
Antipsychotic
Amlodipine Besylate (Norvasc)
Fosamprenavir (Lexiva)
Pioglitazone (Actos)
Diabetes
Amphetamine/Dextroamphetamine (Adderall)
Psychostimulant
Galantamine (Razadyne, Nivalin)
Dementia
Piroxicam (Feldene)
Apixaban (Eliquis)
Anticoagulant
Gefitinib (Iressa)
Prasugrel (Effient)
Platelet Inh
Aripiprazole (Abilify)
Atp Antipsycotic
Gestodene
Progesterone
Prednisolone
Corticosteriod
Artemether
Glibenclamide (Micronase, DiaBeta)
Diabetes
Prochlorperazine (Compazine)
Antipsychotic
Atazanavir (Reyataz)
Gliclazide (Diamicron)
Diabetes
Progesterone
Atomoxetine (Strattera)
Glimepiride (Amaryl, GLIMPID)
Diabetes
Proguanil (Paludrine)
Atorvastatin (Lipitor)
Granisetron (Kytril, Sancuso)
Promethazine
Antipsychotic
Belvig (Lorcaserin)
Haloperidol (Haldol)
Antipsychotic
Propafenone (Rythmol)
Antiarrhythmic
Bisoprolol
B Blocker
Hydrocodone
Propofol (Diprivan)
Amnestic
Bortezomib (Velcade)
Ibuprofen
Propoxyphene
Analgesic
Bosentan (Tracleer)
Ifosfamide (Ifex)
Propranolol
B Blocker
Bromocriptine (Cycloset, Parlodel)
Dopamine Agonist
Iloperidone (Fanapt, Fanapta)
Atp Antipsychotic
Protriptyline (Vivactil)
Bufuralol
B Blocker
Imatinib (Gleevec)
Qsymia (Phentermine/Topiramate)
Buprenorphine (Buprenex, Butrans)
Semi-Syn Opiod
Imipramine or Melipramine (Tofranil)
Quetiapine (Seroquel)
Atp Antipsychotic
Buprenorphine/Naloxone (Suboxone)
Semi-Syn Opiod
Indinavir (Crixivan)
Quinidine
Antiarrhythmic
Bupropion (Aplenzin, Wellbutrin)
Atp Antidepressant
Indomethacin or Indomethacin
Buspirone (BuSpar)
Non-BZD Anxiolytic
Irbesartan (Aprovel, Karvea, Avapro)
Ranitidine (Zantac)
Caffeine
Stimulant
Isradipine (DynaCirc, Prescal)
Rabeprazole (AcipHex)
Carbamazepine (Tegretol, Equetro)
Anticonvulsant
Itraconazole
Antifungal
Reboxetine
Carisoprodol (Soma)
Muscle Relaxant
Ketamine
Anesthesia
Remoxipride (Roxiam)
Atp Antipsychotic
Carvedilol
B Blocker
Ketoconazole
Antifungal
Repaglinide (Prandin)
Celecoxib (Celebrex,Celebra,Onsenal)
Lansoprazole (Prevacid)
Gastric PPI
Rifabutin
Chloramphenicol
Antibiotic
Letrozole (Femara)
Risperidone (Risperdal)
Atp Antipsychotic
Chlorphenamine or Chlorpheniramine
Antihistamine
Lidocaine
Anesthetic
Ritonavir (Norvir)
Chlorpromazine (Thorazine)
Antipsychotic
Loperamide (Imodium)
Rivaroxaban (Xarelto)
Anticoagulant
Ciclosporin or Cyclosporine
Immunosuppresant
Lopinavir/ritonavir (Kaletra)
Rosiglitazone (Avandia)
Diabetes
Citalopram (Celexa)
Loratadine (Claritin)
Rosuvastatin (Crestor)
Clarithromycin
Antibiotic
Lorcaserin (Belvig)
Saquinavir
Clobazam (Onfi, Frisium)
Anticonvulsant
Losartan (Cozaar)
Saxagliptin (Onglyza)
Diabetes
Clomipramine (Anafranil)
Loxapine (Loxitane)
Antipsychotic
Sertraline (Zoloft)
Clonazepam (Klonopin)
Lumefantrine/Artemether (Riamet)
Sildenafil (Viagra)
Clopidogrel (Plavix)
Antiplatelet
Maprotiline
Silodosin (Rapaflo)
Clozapine (Clozaril, FazaClo)
Atp Antipsycotic
MDMA (Ecstasy)
Empathogen
Simvastatin (Zocor)
Medroxyprogesterone acetate (syn progesterone)
Sirolimus (Rapamycin)
Antibiotic
Colchicine (Colcrys)
Mefenamic Acid (Ponstel)
Solifenacin (Vesicare)
Cortisol (Hydrocortisone)
Glucocorticoid
Meloxicam
Sorafenib (Nexavar)
Cyclophosphamide
Meperidine hydrochloride or Pethidine (Demerol)
Opiod Analgesic
Sparteine
Darifenacin (Enablex)
Methadone
Syn Opiod
Sufentanil (Sufenta)
Opiod Analgesic
Darunavir (Prezista)
Methylprednisolone
Glucocorticoid
Sulfamethoxazole (Bactrim)
Antibiotic
Dasatinib (Sprycel)
Methotrimeprazine (Nosinan, Nozinan)
Antipsychotic
Sunitinib (Sutent)
Desipramine (Norpramin)
para-Methoxyamphetamine (PMA)
Tacrolimus (Prograf, Advagraf)
Desogestrel
Metoclopramide (Reglan)
Tadalafil (Cialis)
Dexfenfluramine (Redux)
Metoprolol (Lopressor)
B Blocker
Tamoxifen (Nolvadex, Istubal)
Dexamethasone
Glucocorticoid
Mexiletine
Antiarrhythmic
Tamsulosin (Flomax)
Dextroamphetamine
Psychostimulant
Mianserine
Telithromycin (Ketek)
Antibiotic
Dextromethorphan
Antitussive
Midazolam
Tenoxicam (Mobiflex)
Dextrorphan
Antitussive/Hallucinogen
Mifepristone (RU486)
Terbinafine hydrochloride
Antifungal
Dextromethorphan/Quinidine (Neudexta)
Minaprine
Terfenadine (Seldane)
Diazepam (Valium)
Mirtazapine (Remeron)
Terazosin (Hytrin)
Diclofenac
Moclobemide
Testosterone
Dienogest
Progestin
Modafinil
Eugeroic
THC (Tetrahydrocannabinol)
Dihydrocodeine
Opiod Analgesic
Molindone (Moban)
Antipsychotic
Tetrabenazine
Dihydroergotamine (Migranal)
Migraine
Montelukast
Thioridazine (Mellaril, Novoridazine)
Antipsychotic
Diltiazem
Naloxone
Opiod Antagonist
Ticagrelor (Brilinta)
Platelet Inh
Diphenhydramine
Antihistamine
Naproxen
Timolol (Blocadren)
Docetaxel (Taxotere)
Nateglinide
Diabetes
Tolbutamide (Orinase)
Antidiabetic
Donepezil (Aricept, Donep)
Alzheimer's
Nebivolol
B Blocker
Tolterodine (Detrol)
Doxepin (Silenor, Sinequan)
Nelfinavir
Torasemide (Demadex, Diuver)
Diuretic
Doxazosin (Cardura)
Nevirapine
Tramadol (Ultram)
Opiod Analgesic
Dronedarone (Multaq)
Antiarrhythmic
Nicotine Metabolite
Stimulant
Trazodone (Desyrel, Oleptro)
Duloxetine (Cymbalta)
Nifedipine
Triazolam ( Apo-Triazo, Halcion)
Dutasteride (Avodart)
Nilutamide
Trimipramine (Surmontil, Rhotrimine)
Dutasteride/Tamsulosin (Jayln)
Nilotinib
Tropisetron
5-HT3 Ant
Ecstasy (MDMA)
Empathogen
Nimodipine
Valproic Acid (Depakote)
Anticonvulsant
Efavirenz (Sustiva, Stocrin, Efavir)
Nitrendipine
Vardenafil (Levitra)
Ergotamine
Vasoconstrictor
Norethisterone
Progestogen
Venlaxafine (Effexor)
Erlotinib (Tarceva)
Nortriptyline (Pamelor)
Verapamil (Isoptin, Verelan)
Erythromycin
Antibiotic
Olanzapine (Zyprexa)
Atp Antipsychotic
Vinblastine
Escitalopram (Lexapro)
Olanzapine/Fluoxetine (Symbyax)
Atp Antipsychotic
Vincristine (Oncovin)
Eszopiclone (Lunesta)
Hypnotic
Omeprazole (Prilosec)
Gastric PPI
Voriconazole (VFEND)
Antifungal
Ondansetron
Warfarin (Coumadin)
Anticoagulant
PM 2C9 VOKRC1
Ethinyl estradiol or Ethynyl estradiol
Estrogen
Oxybutynin (Ditropan)
Zafirlukast (Accolate, Accoleit)
Ethosuximide
Anticonvulsant
Oxycodone
Opiod Analgesic
Ziprasidone (Geodon)
Atp Antipsychotic
Etoposide (Etopophos)
Paclitaxel
Zolpidem (Ambien, Intermezzo)
Insomnia
Etravirine (Intelence)
Pantoprazole
Gastric PPI
Zonisamide (Zonegran)
Anticonvulsant
Esomeprazole (Nexium)
Gastric PPI
Paracetamol (Acetaminophen)
Analgesic
Zopiclone
Insomnia
Felbamate (Felbatol)
Anticonvulsant
Paroxetine (Paxil, Pexeva)
Zuclopenthixol (Cisordinol, Clopixol)
Antipsychotic
Major Metabolic Pathway
Drug substrates are listed in alphabetical order according to their International Minor Metabolic Pathway
Nonproprietary Name (non-exhaustive list).
FDA Warnings refer to Genetic Guidance only (PM =Poor Metabolizers)
Non-Exhaustive List : Not a complete list of drugs that utilize the CYP450 System

Source: http://www.floridamedicalsales.com/AppliedGeneticsDNATesting/MetabolicPathwaysChart.pdf

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