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XXXVth Annual Meeting, 10-13 May 2006, Delphi - Greece SCIENTIFIC PROGRAMME
The meeting starts in the afternoon of Wednesday 10 May 2006 and closes official y after the farewell dinner
in the early hours of Sunday 14 May 2006. Wednesday 10 May 2006
15.00 - 21.00
Thursday 11 May 2006
08.00 - 13.00
08.00 - 08.45
Opening ceremony
08.45 - 09.30
I1: Invited lecture
Histamine and the EHRS – what has happened in the last 35 years? Madeleine Ennis, UK 09.30 - 10.30
Oral session 1: Future perspectives in histamine research
Chairpersons: Prof Fred Pearce & Prof Agnieszka Fogel
O1: Novel ligands stabilize stereo-selective conformations of the H1 receptor to result in functionally-selective activation or antagonism of intracel ular signaling pathways Booth RG O2: Fast production and analysis of the human histamine H1 receptors using a cell free protein expression system followed by MS analysis Sansuk K, Bakker RA, Hensbergen P, Leurs R O3: Effect of sulphasalazine and balsalazide on histamine release from mast cells Peh KH, Wan BCY, Assem ESK, Pearce FL O4: Luminometric determination of amine oxidase activity 10.45 - 11.45
Poster session 1: H3 receptors
Chairpersons: Prof Patrizio Blandina & Prof Holger Stark
H3 receptor activation phosphorylates Akt in rat cortical neurons Mariottini C, Chiarugi A, Fossati S, Blandina P, Passani MB H3 receptors modulate [3H]-dopamine release in rat substantia nigra pars reticulata, but not in prefrontal cortex Ramos-Jiménez J, Garduño-Torres B, Camacho J, Arias-Montaño J-A P3: Is the high affinity selective H3 receptor agonist methimepip anxiolytic or anxiogenic in a new validated animal models of human anxiety? Chazot PL, Leurs R, de Esch IJP, Ennaceur A P4: Down-regulation of histamine H3 receptors in rat striatum Garduño-Torres B, Arias-Montaño J-A in vitro ADME properties of immethridine, a potent and highly selective histamine H3-R agonist Celanire S, Gillard M, Christophe B, Quere L, Collart P, Dassesse D, van Marle A, Hulscher S, Bakker R, Zuiderveld P, Timmerman H, Leurs R, Chatelain P, Lamberty Y, Talaga P H3 receptors regulate glutamate, but not GABA release in rat thalamus Garduño-Torres B, Treviño M, Gutiérrez R, Arias-Montaño J-A XXXVth Annual Meeting, 10-13 May 2006, Delphi - Greece P7: Heterocyclic replacements for the central phenyl-core of diamine–based human P8: Histamine 3 receptor inverse agonists for the treatment of obesity. Biological and chemical challenges Freichel C, Gatti-Mac Arthur S, Hertel C, Huwyler J, Nakagawa T, Nettekoven M, Plancher J-M, Raab S, Richter H, Roche O, Sarmiento RMR, Schuler F, Taylor S, P9: Ureas with H3-antagonist activity–a new scaffold discovered by lead-hopping starting from cinnamic acid amides Lau J, Jensen CB, Lund P, Hohlweg R P10: Radiosynthesis and biodistribution of a histamine H3 receptor antagonist: evaluation of a potential pet ligand Airaksinen AJ, Jablonowski JA, Van der May M, Barbier AJ, Klok RP, Verbeek J, Schuit R, Herscheid JDM, Leysen JE, Carruthers NI, Lammertsma AA, Windhorst AD P11: (3-Piperidin-1-yl-propoxy)-tetrahydroisoquinolines and tetra-hydroazepines: A novel series of selective histamine H3 receptor antagonists Jesudason CD, Beavers LS, Cramer JW, Dill J, Finley DR, Gleason SD, Hemrick-Luecke SK, Lindsley CW, Nelson DLG, Stevens FC, Gadski RA, Oldham SW, Pickard RT, Siedem CS, Sindelar DK, Singh A, Watson BM, Witkin JM, Hipskind PA 10.45 - 11.45
Poster session 2: Mast cells and Basophils
Chairpersons: Dr Nina Grosman & Dr El-Sayed K Assem P12: Mast cell-derived interleukin-8 may be involved in the ovarian mechanisms of Szukiewicz D, Pyzlak M, Klimkiewicz J, Szewczyk G, Maslinska D P13: Potent histamine-releasing activity of atrahagin, a snake venom metalloproteinase Wei JF, Mo YZ, Qiao LY, Wei XL, Chen HQ, Xie H, Fu YL, He SH P14: Gene expression profiling of mouse mucosal mast cell (mMMC) proteases Wiener Z, Keszei M, Gilicze A, Falus A P15: Distribution of mast cel - tryptase and metallothionein in human brains with amyloid deposit Maślińska D, Laure-Kamionowska M, Maśliński KT, Gujski M, Maśliński S P16: Clinico-biological characteristics of flow cytometry applied to NSAIDs hypersensitivity diagnosis. Determination of preliminary ROC curves Sainte-Laudy J, Touraine F, Boumediene A, Cogné M P17: Amitriptyline inhibits mast cell histamine secretion: implications for chronic fatigue syndrome therapy Theoharides TC, Kempuraj D P18: Lack of endogenous histamine affects early inflammatory phase of wound healing versus intramuscular steroid administration in a histamine-induced Chimona TS, Panayiotides JG, Papadakis CE, Helidonis ES, Velegrakis GA P20: A heretofore undisclosed crux of eosinophilia-myalgia syndrome: compromised P21: Music therapy, “adverse” diet and histamine Hanke A, Klawitter B, Meng H, Herwald M, Hasenmaier M, Borck H, Fischer M, Diel E, Diel F XXXVth Annual Meeting, 10-13 May 2006, Delphi - Greece P22: Analysis of human basophil activation feed back induced by histamine and high 11.45 - 13.00
Oral session 2: Allergy and Inflammation
Chairpersons: Prof Friedhelm Diel & Prof Marija Čarman-Kržan 11.45 - 12.00 O5: Activation of cannabinoid receptors prevents allergen-induced asthma-like reaction in sensitized guinea pigs Fabrizi F, Vannacci A, Giannini L, Mariottini C, Passani MB, Mannaioni PF, Nistri S, Masini E O6: Effects of the carbon monoxide releasing molecule CORM-3 in a coincubation model with rat mast cells and human neutrophils Vannacci A, Giannini L, Fabrizi F, Uliva C, Mastroianni R, Masini E, Mannaioni PF O7: Prevention of antigen-induced bronchoconstriction by epigallocatechine-3-gallate Giannini L, Uliva C, Bani D, Mastroianni R, Suzuki Y, Nistri S, Mannaioni PF, Suzuki H, Masini E O8: Increased nitric oxide production mediates T cel signal transduction in histidine Koncz A, Nagy G, Mazan M, Buzás E, Falus A O9: Histamine influences the DNA interaction of STATs in human lymphocytes 13.00 - 13.30
Poster session 3: Histamine in the CNS
Chairpersons: Dr Zsuzsanna Huszti and Dr Gill Sturman P25: Excitatory effect of histamine on neuronal activity of rat globus pallidus by activation of H2 receptors in vitro P27: Histamine improves rat rota-rod and balance beam performances through H2 receptors in the cerebellar interpositus nucleus Song Y-N, Li H-Z, Zhu J-N, Wang J-J P28: P2Y receptor mediated excitation in the posterior hypothalamus Sergeeva OA, Klyuch BP, Fleischer W, Eriksson K, Korotkova TM, Siebler M, Haas HL P29: Central histaminergic system – the regulatory mechanism of circulatory 13.00 - 13.30
Poster session 4: Histamine in the GI tract
Chairpersons: Dr Frank Ahrens & Dr Hegyi Krisztina P30 Amitriptyline affects guinea pig post-heparin plasma diamine oxidase activity P31: Immunolocalization of histamine H3 receptor in the rat gastrointestinal tract Chazot PL, Shenton FC, Schunack W, Grandi D, Morini G H3/H4 receptor antagonist thioperamide on regional haemodynamics in rats with trinitrobenzene sulfonic acid-induced colitis Fogel AW, Jochem J, Lewinski A XXXVth Annual Meeting, 10-13 May 2006, Delphi - Greece P34: Functional gut mucosal biopsy testing using tolerated food antigens during mucosa oxygenation yields a high extent of specificity in non-atopic, non-allergic healthy individuals Raithel M, Sehnert C, Nägel A, Backhaus B, Straube S, Buchwald W, Schultis W, Kressel J, Hahn EG, Kimpel S, Konturek P P35: Mechanisms underlying the radioprotective effect of histamine on smal intestine Medina VA, Mohamad NA, Croci M, Cricco GP, Núñez MA, Martín GA, Bergoc Friday 12 May 2006
08.00 - 19.00
08.00 - 08.45
I2: GB WEST lecture
Histamine and systems biology; genes and genomics beyond genes Andras Falus, Hungary Introduced by Prof Madeleine Ennis 08.45 - 9.45
Oral session 3: Metabolism, Reproduction and Cancer
Chairpersons: Prof Madeleine Ennis & Dr Hubert Schwelberger
Medina MA, Aldana JF, Villatoro FR, Claros G, Urdiales JL, Trelles O, Sánchez-Jiménez F 09.00 - 09.15 O11: Effects of histamine on triglyceride breakdown in mouse adipocytes Carpéné C, Bour S, Prévot D, Duffaut C, Valet P 09.15 - 09.30 O12: Highlights in histamine function and reproduction 09.30 - 09.45 O13: Expression of histamine H3 and H4 receptors in benign lesions and malignant carcinomas of the human mammary gland Medina VA, Croci M, Crescenti EJV, Bergoc RM, Rivera ES 09.45 - 11.15
Oral session 4: Histamine and brain
Chairpersons: Dr Paul Chazot & Dr Zoe Papadopoulou-Daifoti
09.45 - 10.00 O14: Generation of the first anti-hH4 receptor antibody: identification of the H4R in human lymphocytes and brain Chazot PL, Shenton FC, Van Rijn RM, Bakker RA, Leurs R 10.15 O15: Aversive memory consolidation and reconsolidation: differences in neurotransmitter engagement. Bucherelli C, Baldi E, Mariottini C, Passani MB, Blandina P 10.15 - 10.30 O16: Properties of native GABAA receptors in histaminergic and orexinergic neurons 10.30 - 10.45 O17: Characteristics of cortical EEG and sleep-wake cycle in histamine H1-receptor Parmentier R, Anaclet C, Watanabe T, Lin J-S 10.45 - 11.00 O18: Histamine and behavioral state-dependent control of hippocampal plasticity 11.00 - 11.15 O19: Whithdrawn 11.15 -12.00 11.30 - 12.00
Poster session 5: Clinical aspects of histamine research
Chairpersons: Dr Anita Sydbom & Dr Mariusz Gujski
P37: Evaluation of urinary N-methylhistamine excretion during a long-term follow up of XXXVth Annual Meeting, 10-13 May 2006, Delphi - Greece patients with inactive Crohn`s disease Kimpel S, Nägel A, Backhaus B, Straube S, Buchwald W, Schultis W, Kressel J, P38: Second-generation antihistamines (SGAs): a systematic review of their effect on quality-of-life (QoL) in intermittent allergic rhinitis (IAR) Golightly LK P39: Do both systemic and topical anti-allergy treatments cause ocular dryness? Gomes P, Abelson MB, Torkildsen G P40: Use of rEV131 for prevention of anterior chamber inflammation in an animal model Gomes P, Lane K, Abelson MB, Weston-Davies W P41: Lidocaine protein binding time response to diphenhydramine administration in rat tissues. Tigka E, Daskala I, Tsagatakis M, Melakopoulos I, Saranteas Th, Tesseromatis C 11.30 - 12.00
Poster session 6: Histamine in Reproduction and Cancer
Chairpersons: Prof Elena S Rivera and Prof Danuta Maślińska P42: Locally secreted histamine may regulate the development of ovarian follicles by Szukiewicz D, Klimkiewicz J, Pyzlak M, Szewczyk G, Maslinska D H4 receptors in human placenta in diabetes-complicated pregnancy. Szewczyk G, Maslinska D, Szukiewicz D, Deregowski K, Smiertka W, Klimkiewicz J, Pyzlak M P44: Histamine increase the invasive potential of human melanoma cel s Pocza P, Kovacs P, Pallinger E, Pocza K, Kohidai L, Falus A, Darvas Z P45: Endogenous and exogenous histamine affects on growth of mice mammary adenocarcinoma Hegyesi H, Molnár V, Fülöp KA, Falus A P46: Nitric oxide involvement in histamine-mediated PANC-1 cel s growth Cricco GrP, Medina VA, Núñez MA, Mohamad NA, Gutiérrez AS, Sanbuco LA, Bergoc RM, Rivera ES, Martín GA P47: Differential modulation of the cellular stress response by histamine and the H1, H2 receptor antagonists in eukaryotic cells Delitheos V, Papamichael K, Tiligada E 12.00 - 13.30
The Art Hancock Young Investigator Award Symposium
Chairpersons: Prof Walter Schunack & Prof Pert i Panula 12.00 - 12.15 O20: Oligomerization of the human histamine H4 receptor van Rijn RM, Chazot PL, Shenton FC, van Marle A, Bakker RA, Leurs R 12.15 - 12.30 O21: Homology modeling of the human histamine H4 receptor and its application in structure-based drug design Kiss R, Jelinek I, Falus A, Noszál B 12.30 - 12.45 O22: Characterization of 4-methylhistamine and VUF 8430 as selective histamine H4R Lim HD, Guaita E, Bakker RA, Coruzzi G, Thurmond RL, Leurs R 12.45 - 13.00 O23: Histaminergic system shapes network synchonization in the hippocampus and striatum in the behaving rat Ponomarenko AA, Unterbrink D, Li J-S, Korotkova TM, Haas HL 13.00 - 13.15 O24: Enhanced CREB activity and adipogenic potential in histamine free embryonic fibroblasts Hegyi K, Falus A, Toth S XXXVth Annual Meeting, 10-13 May 2006, Delphi - Greece 13.15 - 13.30 O25: Excitation of aminergic neurons by histamine Korotkova TM, Sergeeva OA, Ponomarenko AA, Haas HL 14.30 - 17.00
The Art Hancock Memorial Symposium
Chairpersons: Dr Timothy A Esbenshade & Prof Helmut L Haas
Art Hancock: the man, his achievements and his life at the EHRS Timothy A Esbenshade 14.45 - 15.00 O26: Biochemical and pharmacological evidence for homo- and heter-oligomeric human H3 receptor isoforms: further evidence of dominant negative role for splice isoforms Chazot PL, Shenton FC, van Rijn RM, Bakker RA, Leurs R 15.00 - 15.15 O27: New signaling pathways for the histamine H3 receptor Bongers G, van Marle A, Navis M, Bakker RA, Leurs R 15.15 - 15.30 O28: Histamine H3 receptor expression is increased in the brains of transgenic mice over-expressing beta amyloid Ning X, Liu D, Pong K, Pangalos M, Reinhart P, Hirst W 15.30 - 15.45 O29: Different response to GABAA or H3 antagonists suggest the existence of distinct subpopulations among histaminegic neurons Giannoni P, Cenni G, Passani MB, Mannaioni PF, Medhurst AD, Blandina P 15.45 - 16.00 O30: Cloning and expression of histamine H1, H2 and H3 receptors in zebrafish and effects of their ligands on behavior Panula P, Peitsaro N, Sundvik M 16.00 - 16.15 O31: A new family of histamine H3 receptor antagonists based on a natural product: discovery, development of SAR, and properties of the series Cowart M, Sun M, Zhao C, Witte DG, Miller TR, Krueger KM, Browman K, Fox 16.15 - 16.30 O32: Histamine H3 antagonists with serotonin reuptake transporter inhibitor activity 16.30 - 16.45 O33: Pharmacological classification of histamine H3 receptor agents across species is attributable to TM3 sequence differences Gibbs BF, Estvander BR, Miller TR, Baranowski JL, Sharma R, Hancock AA, Krueger KM 17.00 O34: Fluorophore-tagged non-imidazole histamine H3 receptor ligands with Amon M, Ligneau X, Schwartz JC, Stark H 17.15 - 17.50
Poster session 7: Immunology
Chairpersons: Dr Bernhard F Gibbs & Dr Elke Schneider
H1, H2 but not H4 receptors are upregulated during bone marrow regeneration Horváth Z, Pállinger E, Horváth G, Jelinek I, Falus A P50: Unexpected action of histamine on dendritic cells under acidosis Amaral MM, Davio C, Martínez D, Geffner J, Vermeulen M P51: Tissue-related immune-endocrine interactions in experimental hyperthyroidism Kakavas S, Zampeli E, Delitheos V, Tiligada E P52: Histamine stimulates electrogenic ion transport in avian epithelia Collins CB, Campion DP, McGrath J, Baird AW P53: Peripheral but not central effects of allergic reaction are mediated by histamine XXXVth Annual Meeting, 10-13 May 2006, Delphi - Greece P54: Study of adipogenesis in genetically histamine free (HDC KO) and wild type bone 17.15 - 17.50
Poster session 8: Receptors and other subjects
Chairpersons: Prof Tatjana Irman Florjanc & Prof Emanuela Masini
P55: Internalization and resensitization mechanisms of the histamine type 2 receptor Fernández N, Monczor F, Notcovich C, Baldi A, Davio C, Shayo C P56: Strain specific differences in Oct4 expression of HDC KO and wild type ES cells Toth SP, Gocza E, Carstea BV, Falus A in vitro and in vivo H2-H4 receptor selectivity of 4- methylhistamine and VUF8430 Adami M, Guaita E, Lim HD, Bakker RA, de Esch IJP, Leurs R, Coruzzi G P58: Porcine plasma amine oxidase has a broad substrate specificity and efficiently converts histamine Feurle J, Schwelberger HG P59: Influence of amitriptyline on central histamine-induced reversal of haemorrhagic Jochem J, Irman-Florjanc T, Zwirska-Korczala K P60: Altered inflammatory gene expression in genetical y H4 histamine receptor deficient mice Fulop AK, Ribita D, Falus A P61: Involvement of the histaminergic system in the central cardiovascular regulation in haemorrhage-shocked rats with portocaval anastomosis; preliminary data Jochem J, Fogel AW, Maksymowicz M, Zwirska-Korczala K, Lewinski A Saturday 13 May 2006
08.30 - 13.00
08.30 - 09.15
I3: Invited lecture
Occupational asthma: diagnosis and management Piero Maestrelli, Italy Introduced by Prof Pier Francesco Mannaioni 09.15 - 10.30
The D Varonos Memorial Symposium
“Clinical implications – histamine and disease”
Chairpersons: Prof Pier Francesco Mannaioni & Dr Catherine Tiligada Sponsored by GlaxoSmithKline (Greece) 09.15 - 09.30 O35: The histamine H4 receptor mediates al ergic airway inflammation 09.30 - 09.45 O36: Distribution pattern of histamine H4 receptor in human synovial tissue from patients with rheumatoid arthritis Jablonowska M, Grzybowska-Kowalczyk A, Wojtecka-Lukasik E, Maslinska D, Gujski M, Maslinski S 09.45 - 10.00 O37: Theophylline as “add-on” therapy to cetirizine in patients with chronic idiopathic urticaria: a randomized, double-blind, placebo-controlled pilot study Makris M, Kalogeromitros D, Kempuraj D, Katsarou-Katsari A, Grigoriou S, Theoharides TC 10.00 - 10.15 O38: Biphasic immunomodulating effect of cepharolsporin derivatives in man in vitro Assem ESK, Ezeamuzie CI, Vickers MR XXXVth Annual Meeting, 10-13 May 2006, Delphi - Greece 10.15 - 10.30 O39: On the mechanism of antiphagocyte-antioxidative effect of H1-antihistamines Nosal R, Drabikova K, Jancinova V, Pecivova J, Macickova T, Holomanova D 11.00 - 12.50
Oral session 5: Neuro-immuno-endocrine aspects of histamine
Chairpersons: Prof Wilfried Lorenz & Dr Robin Thurmond
11.00 - 11.35 O40: Evidence of human mast cell function in inflammatory diseases Theoharides TC, Cao J, Papadopoulou N, Kempuraj D, Tagen M 11.35 - 11.50 O41: Whithdrawn 11.50 - 12.05 O42: Skin histidine decarboxylase (HDC) and corticotropin-releasing hormone receptor-1 (CRH-R1) genes are overexpressed in chronic urticaria (CU) Kalogeromitros D, Papadopoulou N, Staurianeas NG, Tiblalexi D, Theoharides TC 12.05 - 12.20 O43: Role of histamine in ghrelin-induced gastroprotection against acute gastric lesions Konturek PC, Brzozowski T, Pajdo R, Konturek SJ, HahnEG, Raithel M 12.20 - 12.35 O44: Gastric effects of the histamine H4 receptor antagonists JNJ7777120 and Coruzzi G, Adami M, Guaita E, de Esch IJP, Leurs R 12.35 - 12.50 O45: G protein receptor kinases (GPKs) regulate histamine H2R desensitization in human leukemic cel s Fernández N, Monczor F, Tubio MR, Baldi A, Shayo C, Davio C 14.00 - 16.30
The EUBREN Basophil network symposium
Chairpersons: Dr Franco Falcone & Prof Clemens Dahinden Introduction to EUBREN Franco Falcone 14.10 - 14.30 O46: Control of basophil functions through histamine and other biogenic amines Schneider E, Machavoine F, Pléau J-M, Ohtsu H, Watanabe T, Schinkel AH, 14.30 - 14.50 O47: In vitro and in-vivo stimulatory potential of bone marrow-derived mast cell on Hegyesi H, Darvas Z, Wiener Z, Molnár V, Pos Z, Falus A 14.50 - 15.10 O48: Substantial differences in the kinetics of histamine release from human basophils caused by varying strengths of IgE-dependent activators Gibbs BF, Räthling A, Zillikens D, Huber M, Haas H 15.10 - 15.30 O49: The IL-4-inducing principle from S. mansoni eggs (IPSE) activates human basophils via a novel mechanism: “IgE receptor engagement without crosslinking” Blindow S, Schramm G, Gronow A, Manske M, Galle J, Grevelding CG, Weimar T, Sutton BJ, Gibbs BF, Doenhoff MJ, Haas H 15.30 - 15.50 O50: Accumulation and activation of basophils in allergic disease 15.50 - 16.10 O51: Old and novel mediators of Th2-type immune responses and allergy produced Dahinden CA, Spiegl N, Tschopp CM, Didichenko S 16.10 - 16.30 O52: “British diet on a chip”: A novel diagnostic tool for the detection of food allergy combining protein microarrays with human basophils Lin J, Schramm G, Haas H, Falcone FH, Alcocer MJC XXXVth Annual Meeting, 10-13 May 2006, Delphi - Greece 17.15 - 19.00
General assembly
Sunday 14 May 2006

Source: http://conferences.med.uoa.gr/ehrs-06/BODY/SCIENTIFIC%20PROGRAMME/Program_FINAL_4_4_06.pdf