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How We Silence Our Brain’s Signal for Rest
In a certain historic act of rebellion against escalating British taxes on tea, a group of disguised
colonists dumped a large shipment of the stuff into the Boston harbor in 1774. Tea was out.
And almost overnight drinking coffee became a symbol of American patriotism and freedom.
Cup for cup, coffee has three times more caffeine than tea does. We showed the British!
Our founding fathers proceeded to draft their strategies to liberate a new nation – in
coffeehouses. Member of the Continental Congress first read the Declaration of Independence
aloud to the public at Merchant’s Coffee House in Philadelphia. Little did they know that they
were also establishing a tradition that would shape our lifestyles and identities in a profound
way for centuries to come. Coffee, especially, has become an integral part of our culture and
our selves. As David Letterman once said, “If it wasn’t for coffee, I would have no discernible
Caffeine, found in coffee, tea, many soft drinks, chocolate products, and a variety of
medications, is our world’s most popular drug. The National Coffee Association reports that 54
percent of the U.S. adult population drinks coffee daily, while an additional 25 percent of
Americans drink coffee occasionally. We consume approximately four hundred cups of coffee
per capita each year. Between 80 and 90 percent of us consume caffeine in one form or
another every single day. And we are not alone. As an international commodity, coffee is
Particularly in the form of coffee, caffeine is the primary fuel for the vehicle of our personal
drive. It is our traditional “leaded” gasoline. More popular than nicotine and alcohol, caffeine
is deeply integrated into the fabric of modern life and readily accessible. Despite the fact that it
is a fairly potent drug with complex properties and widespread influences on our biological and
psychological functions, caffeine still remains completely unregulated. Given the broad and
uncertain range of its medical implications, if caffeine were introduced as a new drug today,
experts agree that it simply would not meet with FDA approval.
The period of active influence of a drug or chemical in the body is measured in terms of its half-
life, the amount of time it takes the body to metabolize about one-half of the substance in our
blood. The half-life of caffeine can vary from several hours to several days. For a nonsmoking
adult the effects can last from about five to seven hours. Various medications, the use of oral-
contraceptives, and pregnancy can significantly lengthen the half-life of caffeine. Grapefruit
contains a substance called naringin, which also increases the half-life of caffeine. Cigarette
smoking reduces the half-life of caffeine to about three hours, probably contributing to
smokers consuming more coffee than nonsmokers.
Though many argue that they drink coffee because they “love the taste,” it is more likely that
caffeine is so popular today because it serves as a potent stimulant. It speeds up metabolism,
raises blood pressure and heart rate, and accelerates breathing. It also can temporarily offset
the effects of sleep and dream deprivation. Although sensitivity to caffeine varies widely, doses
ranging from 250 to 750 mg (about two to seven cups of coffee) can result in restlessness,
disturbed sleep, tension, and even cardiac arrhythmias.
Caffeine increases the release of adrenaline, which increases alertness and in sufficient
quantities can cause varying degrees of a flight-or-fight reaction. Contrary to popular belief,
caffeine does not literally provide us with extra energy; it primarily masks our experience of
depletion. Adenosine is a natural by-product of the body’s burning of fuel, a kind of recyclable
exhaust. As available energy supplies are used up, adenosine levels rise, reach a threshold, and
trigger special receptors in the brain that signal the experience of sleepiness. When caffeine is
ingested, it quickly binds with these same receptors, blocking their sensitivity to adenosine.
Consequently, the message of exhaustion then does not reach the brain and body. Caffeine
does not provide us with more fuel – it essentially damages our fuel gauge, misleading us into
Recent studies have determined that caffeine also suppresses melatonin. Given the critical role
of melatonin in maintaining general health and promoting sleep and dreams, we may need to
seriously reconsider the cavalier attitude with which we regularly consume this potent drug. In
neurotherapy practice, it is common of clients with overarousal issues, or various forms and
symptoms of anxiety, to engage often as caffeine consumers – until they become aware of the
high cost they were paying in inner peacefulness.
About FDA-approved cholinesterase inhibitors Prepared by the Alzheimer’s Association. Updated Dec. 15, 2003. The U.S. Food and Drug Administration (FDA) has approved two classes of drugs to treat cognitive symptoms of Alzheimer’s disease. The first Alzheimer medications to be approved were cholinesterase ( KOH luh NES ter ays ) inhibitors. Three of these drugs are commonly p
TABLETS MIDAMOR ® (AMILORIDE HCl) DESCRIPTION Amiloride HCl, an antikaliuretic-diuretic agent, is a pyrazine-carbonyl-guanidine that isunrelated chemically to other known antikaliuretic or diuretic agents. It is the salt of a moderatelystrong base (pKa 8.7). It is designated chemically as 3,5-diamino-6-chloro- N -(diaminomethylene)pyrazinecarboxamide monohydrochloride, dihydrate and has